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Development of an antiseizure drug screening platform for Dravet syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program.

Autor: Pernici CD; Epilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT, USA.; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Mensah JA; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Dahle EJ; Epilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT, USA.; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Johnson KJ; Epilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT, USA., Handy L; Epilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT, USA., Buxton L; Epilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT, USA.; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Smith MD; Epilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT, USA.; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., West PJ; Epilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT, USA.; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Metcalf CS; Epilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT, USA.; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Wilcox KS; Epilepsy Therapy Screening Program (ETSP) Contract Site, University of Utah, Salt Lake City, UT, USA.; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA.

Publikováno v: Epilepsia [Epilepsia] 2021 Jul; Vol. 62 (7), pp. 1665-1676. Date of Electronic Publication: 2021 May 17.

Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy.

Autor: Patel DC; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112., Wallis G; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112., Dahle EJ; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112.; Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT 84112., McElroy PB; Department of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045., Thomson KE; Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT 84112., Tesi RJ; INmune Bio, Seattle, WA 98117., Szymkowski DE; Xencor Inc., Monrovia, CA 91016., West PJ; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112.; Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT 84112., Smeal RM; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112.; Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT 84112., Patel M; Department of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045., Fujinami RS; Department of Pathology, University of Utah, Salt Lake City, UT 84112., White HS; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112.; Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT 84112., Wilcox KS; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112.; Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT 84112.

Publikováno v: ENeuro [eNeuro] 2017 May 09; Vol. 4 (2). Date of Electronic Publication: 2017 May 09 (Print Publication: 2017).

Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy.

Autor: Loewen JL; From the Interdepartmental Program in Neuroscience (JLL, HSW, KSW); HHMI Med into Grad Program (JLL); Department of Pharmacology and Toxicology (JLL, MLB-H, EJD, HSW, KSW); and Anticonvulsant Drug Development Program (MLB-H, EJD, HSW, KSW), University of Utah, Salt Lake City, Utah, USA., Barker-Haliski ML; From the Interdepartmental Program in Neuroscience (JLL, HSW, KSW); HHMI Med into Grad Program (JLL); Department of Pharmacology and Toxicology (JLL, MLB-H, EJD, HSW, KSW); and Anticonvulsant Drug Development Program (MLB-H, EJD, HSW, KSW), University of Utah, Salt Lake City, Utah, USA., Dahle EJ; From the Interdepartmental Program in Neuroscience (JLL, HSW, KSW); HHMI Med into Grad Program (JLL); Department of Pharmacology and Toxicology (JLL, MLB-H, EJD, HSW, KSW); and Anticonvulsant Drug Development Program (MLB-H, EJD, HSW, KSW), University of Utah, Salt Lake City, Utah, USA., White HS; From the Interdepartmental Program in Neuroscience (JLL, HSW, KSW); HHMI Med into Grad Program (JLL); Department of Pharmacology and Toxicology (JLL, MLB-H, EJD, HSW, KSW); and Anticonvulsant Drug Development Program (MLB-H, EJD, HSW, KSW), University of Utah, Salt Lake City, Utah, USA., Wilcox KS; From the Interdepartmental Program in Neuroscience (JLL, HSW, KSW); HHMI Med into Grad Program (JLL); Department of Pharmacology and Toxicology (JLL, MLB-H, EJD, HSW, KSW); and Anticonvulsant Drug Development Program (MLB-H, EJD, HSW, KSW), University of Utah, Salt Lake City, Utah, USA. karen.wilcox@hsc.utah.edu.

Publikováno v: Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2016 Apr; Vol. 75 (4), pp. 366-78. Date of Electronic Publication: 2016 Mar 04.

Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy.

Autor: Umpierre AD; Interdepartmental Program in Neuroscience, University of Utah, 1401 MREB, 20 North 1900 East, Salt Lake City, UT 84132., Remigio GJ; Interdepartmental Program in Neuroscience, University of Utah, 1401 MREB, 20 North 1900 East, Salt Lake City, UT 84132., Dahle EJ; Department of Pharmacology and Toxicology, University of Utah., Bradford K; Department of Pharmacology and Toxicology, University of Utah., Alex AB; Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT 84108, USA., Smith MD; Department of Pharmacology and Toxicology, University of Utah; Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT 84108, USA., West PJ; Interdepartmental Program in Neuroscience, University of Utah, 1401 MREB, 20 North 1900 East, Salt Lake City, UT 84132; Department of Pharmacology and Toxicology, University of Utah; Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT 84108, USA., White HS; Interdepartmental Program in Neuroscience, University of Utah, 1401 MREB, 20 North 1900 East, Salt Lake City, UT 84132; Department of Pharmacology and Toxicology, University of Utah; Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT 84108, USA., Wilcox KS; Interdepartmental Program in Neuroscience, University of Utah, 1401 MREB, 20 North 1900 East, Salt Lake City, UT 84132; Department of Pharmacology and Toxicology, University of Utah; Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT 84108, USA. Electronic address: karen.wilcox@hsc.utah.edu.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2014 Apr; Vol. 64, pp. 98-106. Date of Electronic Publication: 2014 Jan 09.