Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dahai Gai"'
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/6312e02eb00a44698cf02431802ec07b
Publikováno v:
eLife, Vol 5 (2016)
DNA replication is a fundamental biological process. The initial step in eukaryotic DNA replication is the assembly of the pre-initiation complex, including the formation of two head-to-head hexameric helicases around the replication origin. How thes
Externí odkaz:
https://doaj.org/article/2ad3c2c6b6a64928892a01d91f717c47
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 9, p e1000514 (2009)
Simian virus 40 large tumor antigen (LTag) is an efficient helicase motor that unwinds and translocates DNA. The DNA unwinding and translocation of LTag is powered by ATP binding and hydrolysis at the nucleotide pocket between two adjacent subunits o
Externí odkaz:
https://doaj.org/article/6ab5c0b29a0249d6b6263dd552198ee9
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
When a cell divides to form a new cell, it must also copy its DNA. An important step for starting DNA replication is to break or “melt” the bonds between the two strands of DNA that make up the double helix. This happens at a specific site on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e22b8cdc2381c7c3b90984246b7879
https://doi.org/10.7554/elife.46910
https://doi.org/10.7554/elife.46910
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
DNA replication is a fundamental biological process. The initial step in eukaryotic DNA replication is the assembly of the pre-initiation complex, including the formation of two head-to-head hexameric helicases around the replication origin. How thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e217d74b8158b1197dd8fd3a2cd00a66
https://doi.org/10.7554/elife.18129
https://doi.org/10.7554/elife.18129
Autor:
Xiaojiang S. Chen, Stefan Vila, Bo Zhou, Aaron S. Brewster, Gregory A. Sowd, Ellen Fanning, Xian Yu, Dahai Gai, Charlies L. Xie, Diana R. Arnett
Publikováno v:
Journal of Biological Chemistry. 287:26854-26866
DNA polymerase α-primase (Pol-prim) plays an essential role in eukaryotic DNA replication, initiating synthesis of the leading strand and of each Okazaki fragment on the lagging strand. Pol-prim is composed of a primase heterodimer that synthesizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e52c9bc8e268673616033ba94f5104d
https://doi.org/10.1074/jbc.m112.363655
https://doi.org/10.1074/jbc.m112.363655
Publikováno v:
Journal of Virology. 82:6017-6023
The high-resolution structural data for simian virus 40 large-T-antigen helicase revealed a set of nine residues bound to ATP/ADP directly or indirectly. The functional role of each of these residues in ATP hydrolysis and also the helicase function o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf4cc086676b0b55b7125e2ced76f06
https://doi.org/10.1128/jvi.00387-08
https://doi.org/10.1128/jvi.00387-08
Autor:
Dawei Li, Xiaojiang S. Chen, Poonam Taneja, Ellen Fanning, Carla V. Finkielstein, Robert D. Ott, Dahai Gai
Publikováno v:
Journal of Biological Chemistry. 279:38952-38959
The large T (LT) antigen encoded by SV40 virus is a multi-domain, multi-functional protein that can not only transform cells but can also function as an efficient molecular machine to unwind duplex DNA for DNA replication. Here we report our findings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9054f358142bde81bd4293a779ff0aa
https://doi.org/10.1074/jbc.m406160200
https://doi.org/10.1074/jbc.m406160200
Publikováno v:
Nucleic Acids Research. 32:1103-1112
The assembly of the complex that forms over the simian virus 40 origin to initiate DNA replication is not well understood. This complex is composed of the virus-coded T antigen and three cellular proteins, replication protein A (RPA), DNA polymerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075b67853322d19e1ec6040d6b68223a
https://doi.org/10.1093/nar/gkh236
https://doi.org/10.1093/nar/gkh236