Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

Autor: Heidi Yuan, Qin Xu, Dah-Eun Jeong, Ramsey Najm, Maureen E. Balestra, Zachary A. Miller, Yadong Huang, Mary J. Malloy, Bruce L. Miller, Gang Li, Chengzhong Wang, David Walker, Seo Yeon Yoon

Publikováno v: Wang, C; Najm, R; Xu, Q; Jeong, D-E; Walker, D; Balestra, ME; et al.(2018). Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. NATURE MEDICINE, 24(5), 647-+. doi: 10.1038/s41591-018-0004-z. UCSF: Retrieved from: http://www.escholarship.org/uc/item/796161bm
Nature medicine, vol 24, iss 5
Nature medicine

Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce54f33017d611954ee58cce37f37b4f
http://www.escholarship.org/uc/item/796161bm

Cdc28 and Cdc14 Control Stability of the Anaphase-promoting Complex Inhibitor Acm1

Autor: Dah-Eun Jeong, Anton Iliuk, Mark C. Hall, James T. Henderson, Harry Charbonneau, Eunyoung Choi, Steven C. Bremmer

Publikováno v: Journal of Biological Chemistry. 283:10396-10407

The anaphase-promoting complex (APC) regulates the eukaryotic cell cycle by targeting specific proteins for proteasomal degradation. Its activity must be strictly controlled to ensure proper cell cycle progression. The co-activator proteins Cdc20 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07170666c8b5fed728970055e1f8d786
https://doi.org/10.1074/jbc.m710011200

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors*

Autor: Karl H. Weisgraber, Anke Meyer-Franke, Matthew Lloyd Childers, Jens Brodbeck, Richard Hargreaves, Maureen E. Balestra, Dah-Eun Jeong, Casey Cameron Mccomas, Mark T. Goulet, David J. Witter, Fred Hess, Yadong Huang, Nigel J. Liverton, Zhaoping Liu, Scott Peterson, Robert W. Mahley, James G. McGuire, Stephen B. Freedman, Mike Pleiss

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer disease (AD) and likely contributes to neuropathology through various pathways. Here we report that the intracellular trafficking of apoE4 is impaired in Neuro-2a cells and primar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b03270b9c79afc14f77d7b7e2c663b
https://europepmc.org/articles/PMC3089564/

Cdc28 and Cdc14 Control Stability of the Anaphase-promoting Complex Inhibitor Acm1.

Autor: Hall, Mark C.^1,2,3 mchall@purdue.edu, Dah-eun Jeong¹, Henderson, James T.¹, Eunyoung Choi¹, Bremmer, Steven C.¹, Iliuk, Anton B.¹, Charbonneau, Harry^1,2

Publikováno v: Journal of Biological Chemistry. 4/18/2008, Vol. 283 Issue 16, p10396-10407. 12p. 2 Charts, 6 Graphs.

Unique D Box and KEN Box Sequences Limit Ubiquitination of Acm1 and Promote Pseudosubstrate Inhibition of the Anaphase-promoting Complex.

Autor: Eunyoung Choi¹, DiaI, J. Michael², Dah-Eun Jeong¹, HalI, Mark C.^1,3 mchall@purdue.edu

Publikováno v: Journal of Biological Chemistry. 8/29/2008, Vol. 283 Issue 35, p23701-23710. 10p. 1 Chart, 1 Graph.