Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daguang Zhu"'
Autor:
Dao Lentz, Marc Whitlow, Zheng Chang, Harald Dinter, Mike Ferrer, Silke Finster, Marc Adler, Daguang Zhu, Sandra L. Biroc, Richard I. Feldman, Bruno Alicke, Monica Kochanny, Judi Bryant, Brad O. Buckman, Mark A. Polokoff, Arnaiz Damian O, James M. Wu, Shendong Yuan
Publikováno v:
Journal of Biological Chemistry. 280:19867-19874
The phosphoinositide 3-kinase/3-phosphoinositide-dependent kinase 1 (PDK1)/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumor angiogenesis and represents a promising target for anticancer drugs. Here, we describe three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5088ddc20f2394f04c36606bd1d432b
https://doi.org/10.1074/jbc.m501367200
https://doi.org/10.1074/jbc.m501367200
Autor:
Rhonda Humm, Ron Vergona, Rudolf Knauthe, Lynn Webster, Sharon Aberle, Gabor M. Rubanyi, Deborah A. Zajchowski, Karl-Heinrich Fritzemeier, Daguang Zhu, Katalin Kauser, Phyllis A. Ponte, Hsiao-Lai Liu, Frank A. White, Jean MacRobbie, Christa Hegele-Hartung
Publikováno v:
Journal of Biological Chemistry. 275:15885-15894
Clinical studies have shown that estrogen replacement therapy (ERT) reduces the incidence and severity of osteoporosis and cardiovascular disease in postmenopausal women. However, long term estrogen treatment also increases the risk of endometrial an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abfd63b3af30f5a78b68568c52c7d9d
https://doi.org/10.1074/jbc.m909865199
https://doi.org/10.1074/jbc.m909865199
Multiple members of the connexin gene family participate in preimplantation development of the mouse
Publikováno v:
Developmental Genetics. 18:234-243
The connexin gene family, of which there are at least 12 members in rodents, encodes the protein subunits intercellular membrane channels (gap junction channels). Because of the diverse structural and biophysical properties exhibited by the different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3eb871cadc2f431292fbbd7c80b9db5
https://doi.org/10.1002/(sici)1520-6408(1996)18:3<234::aid-dvg4>3.0.co
https://doi.org/10.1002/(sici)1520-6408(1996)18:3<234::aid-dvg4>3.0.co
Autor:
S. Kulkarni, Tyler C. Davies, P.A. De Sousa, Janet Rossant, Gerald M. Kidder, Andrew G. Reaume, Daguang Zhu, B. L. Langille, Subhash C. Juneja
Publikováno v:
Science. 267:1831-1834
Gap junctions are made up of connexin proteins, which comprise a multigene family in mammals. Targeted mutagenesis of connexin43 (Cx43), one of the most prevalent connexin proteins, showed that its absence was compatible with survival of mouse embryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6eb78a75f1226f03729a15cf440f82e
https://doi.org/10.1126/science.7892609
https://doi.org/10.1126/science.7892609
Publikováno v:
Experimental Cell Research. 206:72-84
In the past, we transfected C6 glioma cells with connexin43 cDNA, resulting in a significant increase in connexin43 mRNA and protein, as well as reduced proliferation and tumorigenesis. To investigate the morphological aspects of increased connexin43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7275a1662dd7b76a548c0325957aa65
https://doi.org/10.1006/excr.1993.1122
https://doi.org/10.1006/excr.1993.1122
Publikováno v:
Proceedings of the National Academy of Sciences. 89:10218-10221
To examine the role of gap-junctional intercellular communication in controlling cell proliferation, we have transfected C6 glioma cells with connexin 43 cDNA. The growth of transfected clones was dramatically reduced compared with nontransfected gli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376fbd667ef007e0cc13e1dca140e7a7
https://doi.org/10.1073/pnas.89.21.10218
https://doi.org/10.1073/pnas.89.21.10218
Autor:
Daguang Zhu, Ellen R. Dirksen, Andrew Charles, Michael J. Sanderson, G. M. Kidder, Christian C. Naus
Publikováno v:
The Journal of Cell Biology
Calcium signaling in C6 glioma cells in culture was examined with digital fluorescence video microscopy. C6 cells express low levels of the gap junction protein connexin43 and have correspondingly weak gap junctional communication as evidenced by dye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a645ab266dd6e959bd8463f43644cf
http://europepmc.org/articles/PMC2289532
http://europepmc.org/articles/PMC2289532
Autor:
Deborah Chen, Damian O. Arnaiz, Wei-Wei Li, Feldman Richard, James M. Wu, Marc Whitlow, Shendong Yuan, Mike Ferrer, Brad Buckman, Judi Bryant, Mark A. Polokoff, Daguang Zhu, Bob Mintzer, Zheng Chang, Kumar Emayan, Sandra L. Biroc, Harald Dinter, Xue Snow Ge, Jih-Lie Tseng, Marc Adler, Jian-Ming Gu, Takashi Sato, Jun Shen
Publikováno v:
Chemical biologydrug design. 74(1)
Heat-shock protein-90 is an attractive target for anticancer drugs, as heat-shock protein-90 blockers such as the ansamycin 17-(allylamino)-17-demethoxygeldanamycin greatly reduce the expression of many signaling molecules that are disregulated in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba5a3e56f10ef89bd5c9c6bebd1899e
https://pubmed.ncbi.nlm.nih.gov/19519743
https://pubmed.ncbi.nlm.nih.gov/19519743
Autor:
Victor Hogan, Daguang Zhu, Avraham Raz, Nipa Shah, Pnina Carmi, Rivka Karkash, Tirza Raz, Galit Pazerini
Publikováno v:
International Journal of Cancer. 46:871-877
The endogenous M, 34,000 galaictoside-binding lectin (L-34) is found at elevated levels in a wilde variety of neoplastic cells and correlative evidence suggests that it is involved in tumor metastasis in vivo and in transformation in vitro. We demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cfb1683d7a3105cd9321d7c7423968
https://doi.org/10.1002/ijc.2910460520
https://doi.org/10.1002/ijc.2910460520
Autor:
Arnaiz Damian O, Judi Bryant, Richard I. Feldman, Mark A. Polokoff, Gary Phillips, Paul Hrvatin, Marc Adler, James M. Wu, Babu Subramanyam, Dao Lentz, Imadul Islam, Marc Whitlow, Daguang Zhu, Kochanny Monica, Jun Shen, Janette Walters, Shendong Yuan, Elena Ho, Greg Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(14)
Based on the lead compound BX-517, a series of C-4' substituted indolinones have been synthesized and evaluated for PDK1 inhibition. Modification at C-4' of the pyrrole afforded potent compounds (7b and 7d) with improved solubility and ADME propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ccd70016040387d3840477d0ee0a34
https://pubmed.ncbi.nlm.nih.gov/17544272
https://pubmed.ncbi.nlm.nih.gov/17544272