Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dagoberto Grenet"'
Autor:
Oswaldo A Lozoya, Inmaculada Martinez-Reyes, Tianyuan Wang, Dagoberto Grenet, Pierre Bushel, Jianying Li, Navdeep Chandel, Richard P Woychik, Janine H Santos
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2005707 (2018)
Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a
Externí odkaz:
https://doaj.org/article/956885ce10ee49b489a6dee1a030f6e2
Autor:
Jesse D. Cushman, Gonzalo Riadi, Janine H. Santos, Sheryl S. Moy, Patricia Jensen, Oswaldo A. Lozoya, Tianyuan Wang, Fuhua Xu, Richard P. Woychik, Dagoberto Grenet, Artiom Gruzdev, Thomas B Hagler, Korey D. Stevanovic, Bairon Hernandez
Publikováno v:
Life Science Alliance
This study shows that loss of a brain-specific fusion isoform of PGC1a leads to up-regulation of genes and motor impairments in mice, suggesting functional differences between PGC1 isoforms in the brain.
PGC1α is a transcriptional coactivator i
PGC1α is a transcriptional coactivator i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5d14ad72249ac0290d81facc8447e7
https://pubmed.ncbi.nlm.nih.gov/34649938
https://pubmed.ncbi.nlm.nih.gov/34649938
Autor:
Sheryl S. Moy, Fuhua Xu, Oswaldo A. Lozoya, Gonzalo Riadi, Janine H. Santos, Dagoberto Grenet, Korey D. Stevanovic, Patricia Jensen, Richard P. Woychik, Tianyuan Wang, Jesse D. Cushman, Bairon Hernandez
The peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1α) is known as a transcriptional co-activator in peripheral tissues but its function in the brain remains poorly understood. Various brain-specific Pgc1α isoforms have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f30b903ec1767ede0cb5aea25c2d0cd2
https://doi.org/10.1101/2020.09.18.300418
https://doi.org/10.1101/2020.09.18.300418
Autor:
Sheryl S. Moy, Bairon Hernandez, Korey D. Stevanovic, Dagoberto Grenet, Oswaldo A. Lozoya, Jesse D. Cushman, Artiom Gruzdev, Thomas B Hagler, Fuhua Xu, Patricia Jensen, Richard P. Woychik, Gonzalo Riadi, Janine H. Santos, Tianyuan Wang
Publikováno v:
Life Science Alliance. 4:e202101122
PGC1α is a transcriptional coactivator in peripheral tissues, but its function in the brain remains poorly understood. Various brain-specific Pgc1α isoforms have been reported in mice and humans, including two fusion transcripts (FTs) with non-codi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9541fe6cd3ff63d0eec3228d0e6aac5
https://doi.org/10.26508/lsa.202101122
https://doi.org/10.26508/lsa.202101122
Autor:
Suramya Waidyanatha, Oswaldo A. Lozoya, Dagoberto Grenet, Fuhua Xu, Sara A. Grimm, Tianhong Wang, Richard P. Woychik, Janine H. Santos, Godfrey Vg
Mitochondrial-driven alterations of the epigenome have been reported but whether they are relevant at the organismal level remain unknown. The viable yellow agouti mouse (Avy) is a powerful epigenetic biosensor model that reports on the DNA methylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85080fc20ae7e680699c659d72ce7ade
Autor:
Oswaldo A. Lozoya, Tianyuan Wang, Veronica B. Godfrey, Janine H. Santos, Dagoberto Grenet, Suramya Waidyanatha, Richard P. Woychik, Fuhua Xu, Sara A. Grimm
Publikováno v:
Cell reports
SUMMARY Mitochondrial-driven alterations of the epigenome have been reported, but whether they are relevant at the organismal level remains unknown. The viable yellow agouti mouse (Avy) is a powerful epigenetic biosensor model that reports on the DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4d14a98f08f992fce3ce6c10c1efce
https://doi.org/10.1016/j.celrep.2020.108131
https://doi.org/10.1016/j.celrep.2020.108131
Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression
Autor:
Mack Sobhany, Gonzalo Riadi, Janine H. Santos, Oswaldo A. Lozoya, Douglas Ganini da Silva, Taylor C. Wolfgang, Tianyuan Wang, Navdeep S. Chandel, Dagoberto Grenet, Richard P. Woychik
Publikováno v:
Life Science Alliance
This study shows that genetic or pharmacological manipulation of the TCA cycle, when mitochondria are dysfunctional, can modulate histone acetylation and gene expression in the nucleus with physiological outcomes.
The impact of mitochondrial dys
The impact of mitochondrial dys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3771e28caf3af5e52e3d20941dd6d55f
https://pubmed.ncbi.nlm.nih.gov/30737248
https://pubmed.ncbi.nlm.nih.gov/30737248
Autor:
Pierre R. Bushel, Jianying Li, Navdeep S. Chandel, Janine H. Santos, Dagoberto Grenet, Tianyuan Wang, Inmaculada Martínez-Reyes, Oswaldo A. Lozoya, Richard P. Woychik
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1859:e60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ead6ce62ad93d9a66fe9fee36364642
https://doi.org/10.1016/j.bbabio.2018.09.179
https://doi.org/10.1016/j.bbabio.2018.09.179
Autor:
Oswaldo Lozoya, Gonzalo Riadi, Janine H. Santos, Dagoberto Grenet, Tianyuan Wang, Richard Woychik, Douglas Ganini da Silva
Publikováno v:
Free Radical Biology and Medicine. 100:S78
Mitochondria are well-recognized for their role in ATP and reactive oxygen species generation, in addition to producing intermediate metabolites through the TCA (tricarboxylic acid) cycle. We recently showed in an acute model of mitochondrial DNA (mt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1294a2303650f87ec910013e757faeee
https://doi.org/10.1016/j.freeradbiomed.2016.10.196
https://doi.org/10.1016/j.freeradbiomed.2016.10.196
Publikováno v:
Journal of Receptor Research. 11:587-601
We describe an updated and improved protocol to perform urea gradient/SDS-PAGE in which proteins are electrophoresed through 9% polyacrylamide gel slabs in the presence of a linear 4 M to 8 M gradient of urea using Laemmli's separation buffers. We pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e007aa8d08e4eab098285fed623011c
https://doi.org/10.3109/10799899109066429
https://doi.org/10.3109/10799899109066429