Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dagny Grzech"'
Autor:
Tuan-Anh M. Nguyen, Dagny Grzech, Khoa Chung, Zhicheng Xia, Trinh-Don Nguyen, Thu-Thuy T. Dang
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension. Despite thei
Externí odkaz:
https://doaj.org/article/0122f565b7344705acbec756a7913021
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Plants produce a wide variety of pharmacologically active molecules classified as natural products. Derivatization of these natural products can modulate or improve the bioactivity of the parent compound. Unfortunately, chemical derivatization of nat
Externí odkaz:
https://doaj.org/article/bc725de3968b46d0bea1863ee08f2663
Autor:
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T. Dang, Larissa C. Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R. McCurdy, Sarah E. O’Connor
Publikováno v:
Journal of the American Chemical Society
Mitragyna speciosa(“Kratom”) is used as a natural remedy for pain and management of opioid dependence. The pharmacological properties of Kratom have been linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine. Here,
Autor:
Benke Hong, Dagny Grzech, Lorenzo Caputi, Prashant Sonawane, Carlos E. Rodríguez López, Mohamed Omar Kamileen, Néstor J. Hernández Lozada, Veit Grabe, Sarah E. O’Connor
Publikováno v:
Nature
Strychnine is a natural product that, through isolation, structural elucidation and synthetic efforts, shaped the field of organic chemistry. Currently, strychnine is used as a pesticide to control rodents1 because of its potent neurotoxicity2,3. The
Publikováno v:
ACS Synthetic Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bef0177b2211609d6c81275d4a0e4c
https://hdl.handle.net/21.11116/0000-000C-6FA5-E21.11116/0000-000C-08D9-721.11116/0000-000C-08D6-A
https://hdl.handle.net/21.11116/0000-000C-6FA5-E21.11116/0000-000C-08D9-721.11116/0000-000C-08D6-A
Publikováno v:
ACS synthetic biology.
Vinblastine is a chemotherapy agent produced by the plant
Autor:
Benke Hong, Dagny Grzech, Lorenzo Caputi, Prashant Sonawane, Carlos E. Rodríguez López, Mohamed Omar Kamileen, Néstor J. Hernández Lozada, Veit Grabe, Sarah E. O’Connor
Publikováno v:
Nature. 608:E37-E37
Autor:
Tetsuro Mimura, Dagny Grzech, Sarah E. O'Connor, Vincent Courdavault, Kotaro Yamamoto, Lorenzo Caputi, Konstantinos Koudounas, Emily Amor Stander
Publikováno v:
Plant Physiology
Plant Physiology, American Society of Plant Biologists, 2021, ⟨10.1093/plphys/kiab285⟩
Plant Physiology, American Society of Plant Biologists, 2021, ⟨10.1093/plphys/kiab285⟩
Specialized metabolites are chemically complex small molecules with a myriad of biological functions. To investigate plant-specialized metabolite biosynthesis more effectively, we developed an improved method for virus-induced gene silencing (VIGS).
Autor:
Dagny Grzech, Konstantinos Koudounas, Chloe Langley, Vincent Courdavault, Inês Carqueijeiro, Sarah E. O'Connor, Nicolas Papon
Publikováno v:
Current Opinion in Biotechnology
Current Opinion in Biotechnology, Elsevier, 2020, 65, pp.17-24. ⟨10.1016/j.copbio.2019.11.017⟩
Current Opinion in Biotechnology, Elsevier, 2020, 65, pp.17-24. ⟨10.1016/j.copbio.2019.11.017⟩
Highlights • Plant specialised metabolites constitute an enormous reservoir of anticancer compounds. • Their low bioavailability in planta fails to reach the demand. • Heterologous pathway reconstitution is a promising alternative to massively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a3593d7f75630a1e746dcc5928cb0e
https://hal.univ-angers.fr/hal-02483115
https://hal.univ-angers.fr/hal-02483115