Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Dagmara Klopotowska"'
1
Akademický článek
Downregulation of MALAT1 in triple-negative breast cancer cells
Autor: Dagmara Klopotowska, Janusz Matuszyk
Publikováno v: Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101592- (2024)
Background: MALAT1 is one of the most abundant nuclear long non-coding RNAs, which has been found to be elevated in various types of cancers. However, conflicting reports on MALAT1 in breast cancer cell lines challenge understanding of MALAT1's invol
Externí odkaz: https://doaj.org/article/d3afca66fbc348b0b6261dcd54e86a38
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2
Akademický článek
Vitamin D3 reduces the expression of M1 and M2 macrophage markers in breast cancer patients
Autor: Martyna Stachowicz-Suhs, Natalia Łabędź, Magdalena Milczarek, Dagmara Kłopotowska, Beata Filip-Psurska, Adam Maciejczyk, Rafał Matkowski, Joanna Wietrzyk
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract Vitamin D3 (VD) is known for its immunomodulatory and anticancer effects. This study aimed to characterize tumor-associated macrophages (TAMs) in breast cancer (BC) and assess the influence of VD and its active metabolite, calcitriol, on the
Externí odkaz: https://doaj.org/article/223fb776c35e4eea837e283d9b35a21d
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3
Design, synthesis and antiproliferative activity against human cancer cell lines of novel benzo-, benzofuro-, azolo- and thieno-1,3-thiazinone resorcinol hybrids
Autor: Monika Karpińska, Joanna Wietrzyk, Wojciech Rzeski, Małgorzata Juszczak, Andrzej Niewiadomy, Joanna Matysiak, Alicja Skrzypek, Dagmara Klopotowska, Beata Paw
Publikováno v: Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 2655-2667 (2019)
In this paper we report the design and synthesis of novel derivatives of the 4H-3,1-benzothiazinone type and heterocyclic analogues, i.e. benzofuro-, azolo- and thieno-1,3-thiazin-4-ones possessing 2,4-dihydroxyphenyl substituent. The compounds were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7a45aab5b6a58b5ccdf24857b0802e
https://doi.org/10.1016/j.arabjc.2015.05.006
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4
Akademický článek
Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines
Autor: Martyna Stachowicz-Suhs, Natalia Łabędź, Artur Anisiewicz, Joanna Banach, Dagmara Kłopotowska, Magdalena Milczarek, Aleksandra Piotrowska, Piotr Dzięgiel, Adam Maciejczyk, Rafał Matkowski, Joanna Wietrzyk
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Our research found that vitamin D3 (VD3) treatment increased lung metastasis in mice with 4T1 murine breast cancer (BC). This study aims to investigate the impact of VD3 on the activation of tumor-associated macrophages (TAMs) in BC. Mice be
Externí odkaz: https://doaj.org/article/c5d4391874454c9f89e9ea1b38702112
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5
Akademický článek
Dual effect of vitamin D3 on breast cancer-associated fibroblasts
Autor: Natalia Łabędź, Artur Anisiewicz, Martyna Stachowicz-Suhs, Joanna Banach, Dagmara Kłopotowska, Adam Maciejczyk, Patrycja Gazińska, Aleksandra Piotrowska, Piotr Dzięgiel, Rafał Matkowski, Joanna Wietrzyk
Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-25 (2024)
Abstract Background Cancer-associated fibroblasts (CAFs) play an important role in the tumor microenvironment. Despite the well-known in vitro antitumoral effect of vitamin D3 (VD3), its impact on breast CAFs is almost unknown. In this study, we anal
Externí odkaz: https://doaj.org/article/af61e4f6f8be4414807d528c070ecb6e
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6
Vitamin D Metabolite Profile in Cholecalciferol- or Calcitriol-Supplemented Healthy and Mammary Gland Tumor-Bearing Mice
Autor: Dagmara Klopotowska, Konrad Kowalski, Martyna Stachowicz-Suhs, Magdalena Milczarek, Piotr Dziegiel, Artur Anisiewicz, Natalia Łabędź, Joanna Banach, Aleksandra Piotrowska, Joanna Wietrzyk
Publikováno v: Nutrients, Vol 12, Iss 3416, p 3416 (2020)
Nutrients
Volume 12
Issue 11
To analyze if the prometastatic activity of calcitriol (active vitamin D3 metabolite), which was previously observed in a 4T1 breast cancer model, is also found in other breast cancers, and to assess the impact of various schemes of vitamin D supply,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293ec776c3cfc767e671a3df530406d1
https://www.mdpi.com/2072-6643/12/11/3416
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7
Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits
Autor: Dagmara Klopotowska, Joanna Kolniak-Ostek, Krzysztof P. Rutkowski, Dorota Kruczyńska, Anna Skorupińska
Publikováno v: Molecules
Volume 25
Issue 19
Molecules, Vol 25, Iss 4444, p 4444 (2020)
Consuming food that is rich in antioxidants reduces the risk of developing chronic diseases and oxidative stress. Fruits and vegetables are an excellent source of substances with antioxidant and pro-health properties. Such raw materials, characterize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9ad79b6bbbf4fbdb386af2fba498ca
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8
VDR Agonists Increase Sensitivity of MCF-7 and BT-474 Breast Cancer Cells to 5 FU
Autor: Dagmara Klopotowska, Janusz Matuszyk
Publikováno v: Anticancer research. 40(2)
Background/aim The study aimed to test the potential for increasing the antiproliferative activity of 5-fluorouracil against breast cancer cells of various molecular subtypes by vitamin D receptor (VDR) agonists, calcitriol and tacalcitol, used at a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62f466d5f8a03c1da22294b8306dcb2
https://pubmed.ncbi.nlm.nih.gov/32014926
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9
miR-125b lowers sensitivity to apoptosis following mitotic arrest: Implications for breast cancer therapy
Autor: Dagmara Klopotowska, Janusz Matuszyk
Publikováno v: Journal of cellular physiologyREFERENCES. 235(10)
The process of apoptosis begins when the balance between proapoptotic and antiapoptotic stimuli is disturbed, leading to oligomerization of apoptosis effectors and disruption of the outer mitochondrial membrane. BCL-2 family proteins are the major re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d08178c30bd205926105d5096bc81b
https://pubmed.ncbi.nlm.nih.gov/32052874
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10
Divergent Effect of Tacalcitol (PRI-2191) on Th17 Cells in 4T1 Tumor Bearing Young and Old Ovariectomized Mice
Autor: Beata Filip-Psurska, Dagmara Klopotowska, Joanna Wietrzyk, Magdalena Maciejewska, Artur Anisiewicz, Agata Pawlik, Andrzej Mazur
Publikováno v: Aging and Disease
Aging and disease
Aging and disease, Kunlin Jin, 2020, 11 (2), pp.241-253. ⟨10.14336/AD.2019.0618⟩
Aging and disease, 2020, 11 (2), pp.241-253. ⟨10.14336/AD.2019.0618⟩
Vitamin D and its analogs are known for their role in the development of breast cancer and in immunomodulation. Our previous studies have shown the pro-metastatic effect of calcitriol and tacalcitol (PRI-2191) in young mice bearing 4T1 breast cancer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0ea81b4985456492355c707b74f2ce
https://pubmed.ncbi.nlm.nih.gov/32257539
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