Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dagmara K. Derewacz"'
Autor:
Tina M. Iverson, Audrey E Ynigez-Gutierrez, Jeffrey M. Spraggins, Brian O. Bachmann, Emilianne M. Limbrick, Kathryn M. McCulloch, Dagmara K. Derewacz, Callie C Dulin
Publikováno v:
ChemBioChem. 21:3349-3358
Everninomicins are orthoester oligosaccharide antibiotics with potent activity against multidrug-resistant bacterial pathogens. Everninomicins act by disrupting ribosomal assembly in a distinct region in comparison to clinically prescribed drugs. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b393ce36c5526db696bfdaa0d55012
https://doi.org/10.1002/cbic.202000305
https://doi.org/10.1002/cbic.202000305
Autor:
Emilianne M. Limbrick, Daniel N. Wilson, Michael Graf, Dagmara K. Derewacz, Rachel Green, Kathryn M. McCulloch, Fabian Nguyen, Boris Zinshteyn, Jeffrey M. Spraggins, Benjamin J. Reisman, Tina M. Iverson, Audrey E Ynigez-Gutierrez, Brian O. Bachmann, Maximiliane Wieland
Publikováno v:
J Am Chem Soc
Many microorganisms possess the capacity for producing multiple antibiotic secondary metabolites. In a few notable cases, combinations of secondary metabolites produced by the same organism are used in important combination therapies for treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342c606f962a7572b45f8712af744ff3
https://europepmc.org/articles/PMC8129991/
https://europepmc.org/articles/PMC8129991/
Publikováno v:
ACS Chemical Biology. 10:1998-2006
Intergeneric microbial interactions may originate a significant fraction of secondary metabolic gene regulation in nature. Herein we expose a genomically characterized Nocardiopsis strain, with untapped polyketide biosynthetic potential, to intergene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d0f317a5cac87b2269d0bce4a64966
https://doi.org/10.1021/acschembio.5b00001
https://doi.org/10.1021/acschembio.5b00001
Autor:
John A. McLean, Brian O. Bachmann, John P. Wikswo, Cody R. Goodwin, Brett C. Covington, Dagmara K. Derewacz, C. Ruth McNees
Publikováno v:
Chemistry & Biology. 22(5):661-670
SummarySecondary metabolite biosynthesis in microorganisms responds to discrete chemical and biological stimuli; however, untargeted identification of these responses presents a significant challenge. Herein we apply multiplexed stimuli to Streptomyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509423775c1c0199d9c8c2971eb66bbe
Autor:
Giovanni Scalmani, Prasad L. Polavarapu, Ganesh Shanmugam, Brian O. Bachmann, Lawrence J. Marnett, Cody L. Covington, Dagmara K. Derewacz, C. Ruth McNees
Publikováno v:
Journal of Natural Products
Culture extracts from the cave-derived actinomycete Nonomuraea specus were investigated, resulting in the discovery of a new S-bridged pyronaphthoquinone dimer and its monomeric progenitors designated hypogeamicins A–D (1–4). The structures were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485d55491b2a8d8c5eff65964d9c8dd7
http://europepmc.org/articles/PMC4334282
http://europepmc.org/articles/PMC4334282
Autor:
Yu Du, Brian O. Bachmann, Jesse Teske, Jacques Ravel, Dagmara K. Derewacz, Gary A. Sulikowski, Sean M. DeGuire
Publikováno v:
Tetrahedron. 67:6568-6575
The apoptolidins are 20/21-membered macrolides produced by Nocardiopsis sp. FU40. Several members of this family are potent and remarkably selective inducers of apoptosis in cancer cell lines, likely via a distinct mitochondria associated target. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d3d9bbcf9798dd09146a0dcaa5d682
https://doi.org/10.1016/j.tet.2011.05.106
https://doi.org/10.1016/j.tet.2011.05.106
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(6)
Bacteria develop resistance to many classes of antibiotics vertically, by engendering mutations in genes encoding transcriptional and translational apparatus. These severe adaptations affect global transcription, translation, and the correspondingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe4bfa3a9cdb2a640f5045ed82d3431
https://pubmed.ncbi.nlm.nih.gov/23341601
https://pubmed.ncbi.nlm.nih.gov/23341601
Publikováno v:
Journal of natural products. 75(1)
A significant challenge in natural product discovery is the initial discrimination of discrete secondary metabolites alongside functionally similar primary metabolic cellular components within complex biological samples. A property that has yet to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198d7c50a0b7d417de4506e02b3c20ca
https://pubmed.ncbi.nlm.nih.gov/22216918
https://pubmed.ncbi.nlm.nih.gov/22216918