Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Dagmar Meyer zu Heringdorf"'
Autor:
Shah Alam, Sumaiya Yasmeen Afsar, Maya Anik Wolter, Luisa Michelle Volk, Daniel Nicolae Mitroi, Dagmar Meyer zu Heringdorf, Gerhild van Echten-Deckert
Publikováno v:
Cells, Vol 12, Iss 14, p 1844 (2023)
Astrocytes are critical players in brain health and disease. Brain pathologies and lesions are usually accompanied by astroglial alterations known as reactive astrogliosis. Sphingosine 1-phosphate lyase (SGPL1) catalysis, the final step in sphingolip
Externí odkaz:
https://doaj.org/article/08f9df6a206044d48bc12ef5a27d545d
Autor:
Sara Standoli, Cinzia Rapino, Camilla Di Meo, Agnes Rudowski, Nicole Kämpfer-Kolb, Luisa Michelle Volk, Dominique Thomas, Sandra Trautmann, Yannick Schreiber, Dagmar Meyer zu Heringdorf, Mauro Maccarrone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8508 (2023)
Microglia, the resident immune cells of the central nervous system, play important roles in brain homeostasis as well as in neuroinflammation, neurodegeneration, neurovascular diseases, and traumatic brain injury. In this context, components of the e
Externí odkaz:
https://doaj.org/article/ce57612ffd664d9983b7060c04527b23
Autor:
Gergely Imre, Verena Krähling, Madeleine Eichler, Sandra Trautmann, Nerea Ferreirós, M. Javad Aman, Fatah Kashanchi, Krishnaraj Rajalingam, Stefan Pöhlmann, Stephan Becker, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102266- (2021)
Summary: Ebola virus (EBOV) is responsible for outbreaks with case fatality rates of up to 90% and for an epidemic in West Africa with more than ten thousand deaths. EBOV glycoprotein (EBOV-GP) is the only viral surface protein and is responsible for
Externí odkaz:
https://doaj.org/article/a4d3b8fd63584eefb7be8371826ef0f5
Autor:
Thomas Pleli, Antonia Mondorf, Nerea Ferreiros, Dominique Thomas, Karel Dvorak, Ricardo M. Biondi, Dagmar Meyer zu Heringdorf, Stefan Zeuzem, Gerd Geisslinger, Herbert Zimmermann, Oliver Waidmann, Albrecht Piiper
Publikováno v:
Cellular Physiology and Biochemistry, Vol 45, Iss 6, Pp 2516-2528 (2018)
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation of adenylyl cyclase, causing an increase of the intracellular cAMP concentration, activation of the intracellular cAMP effectors protein kinase A (PKA)
Externí odkaz:
https://doaj.org/article/0a4e904e6a144be5903bf729f11e5b78
Autor:
Anna Katharina Spohner, Katja Jakobi, Sandra Trautmann, Dominique Thomas, Fabian Schumacher, Burkhard Kleuser, Dieter Lütjohann, Khadija El-Hindi, Sabine Grösch, Josef Pfeilschifter, Julie D. Saba, Dagmar Meyer zu Heringdorf
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10617 (2021)
Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation. Loss of Sgpl1 in humans and mice leads to accumulation of sphingolipids and multiple organ injuries. Here, w
Externí odkaz:
https://doaj.org/article/e6c0ea5d45a4451fb0d9d6e266b20b1d
Autor:
Kira Vanessa Blankenbach, Ralf Frederik Claas, Natalie Judith Aster, Anna Katharina Spohner, Sandra Trautmann, Nerea Ferreirós, Justin L. Black, John J. G. Tesmer, Stefan Offermanns, Thomas Wieland, Dagmar Meyer zu Heringdorf
Publikováno v:
Cells, Vol 9, Iss 10, p 2201 (2020)
Diverse extracellular signals induce plasma membrane translocation of sphingosine kinase-1 (SphK1), thereby enabling inside-out signaling of sphingosine-1-phosphate. We have shown before that Gq-coupled receptors and constitutively active Gαq/11 spe
Externí odkaz:
https://doaj.org/article/f549208b4be8498faf967cdaab7c6069
Autor:
Katja Ihlefeld, Hans Vienken, Ralf Frederik Claas, Kira Blankenbach, Agnes Rudowski, Michael ter Braak, Alexander Koch, Paul P. Van Veldhoven, Josef Pfeilschifter, Dagmar Meyer zu Heringdorf
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 1, Pp 60-69 (2015)
Sphingosine 1-phosphate (S1P) is an extra- and intracellular mediator that regulates cell growth, survival, migration, and adhesion in many cell types. S1P lyase is the enzyme that irreversibly cleaves S1P and thereby constitutes the ultimate step in
Externí odkaz:
https://doaj.org/article/f071ef55eb7d497a8e684309cb0a5c67
Autor:
Olivier Blanchard, Bisera Stepanovska, Manuel Starck, Martin Erhardt, Isolde Römer, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter, Uwe Zangemeister-Wittke, Andrea Huwiler
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 5, p 1498 (2018)
Sphingosine kinase (SK) catalyses the formation of sphingosine 1-phosphate (S1P), which acts as a key regulator of inflammatory and fibrotic reactions, mainly via S1P receptor activation. Here, we show that in the human renal proximal tubular epithel
Externí odkaz:
https://doaj.org/article/3006f2a5b62e46d497825225e500eff2
Autor:
Dagmar Meyer zu Heringdorf, Corina Ratiu, Amro Elgheznawy, Voahanginirina Randriamboavonjy, Anastasia Kyselova, Ingrid Fleming, Mauro Siragusa, Alexander W. Mann, Beate Fisslthaler, Fredy Delgado Lagos
Publikováno v:
Blood. 137:1641-1651
Secreted modular calcium-binding protein 1 (SMOC1) is an osteonectin/SPARC-related matricellular protein, whose expression is regulated by microRNA-223 (miR-223). Given that platelets are rich in miR-223, this study investigated the expression of SMO
Autor:
Robert Brunkhorst, Sandra Trautmann, Dagmar Meyer zu Heringdorf, Rajkumar Vutukuri, Yannick Schreiber, Josef Pfeilschifter, Dominique Thomas, Waltraud Pfeilschifter, Alexander Koch, Franziska Mayser
Publikováno v:
The FASEB Journal. 34:3932-3942
Sphingosine 1-phosphate (S1P) signaling influences numerous cell biological mechanisms such as differentiation, proliferation, survival, migration, and angiogenesis. Intriguingly, our current knowledge is based solely on the role of S1P with an 18-ca