Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dagmar M. Hajducek"'
Autor:
Dagmar M. Hajducek, Fitri Primacakti, Novie Chozie, Roser Mir, Alanna McEneny-King, Alfonso Iorio, Andrea Edginton
Publikováno v:
Plasmatology, Vol 15 (2021)
Background Population pharmacokinetics (popPK) has been reliably leveraged to generate individual PK in hemophilia patients. Specific popPK models are suited to predict individual PK under a variety of scenarios that may not be captured by clinical t
Externí odkaz:
https://doaj.org/article/def7f90629ae409f9a18f4b66c5c71e4
Autor:
Viviane Grassmann, Dagmar M Hajducek, Andrea N Edginton, Vanessa Bouskill, Christine Brown, Manuel Carcao, David Lillicrap, Roxy H O'Rourke, Roona Sinha, Jayson Stoffman, Cindy Wakefield, Margaret L. Rand, Victor Blanchette
Publikováno v:
Blood. 140:8453-8455
Publikováno v:
Clinical Pharmacokinetics. 61:997-1012
The renal excretion of drugs via organic anion transporters 1 and 3 (OAT1/3) is significantly decreased in patients with renal impairment. This study uses physiologically based pharmacokinetic models to quantify the reduction in OAT1/3-mediated secre
Autor:
Dagmar M. Hajducek, Alanna McEneny-King, Alfonso Iorio, Andrea N. Edginton, Cedric Hermans, Pierre Chelle, Jacky K. Yu
Publikováno v:
Haemophilia. 26:384-400
Background The Web-Accessible Population Pharmacokinetic Service (WAPPS) project generates individually predicted pharmacokinetic (PK) profiles and tailored prophylactic treatment regimens for haemophilic patients, which rely on a set of population P
Autor:
Alfonso Iorio, Dagmar M. Hajducek, Mohammed Mahdi, Josh Silvertown, Andrea N. Edginton, Stuart Young, Pierre Chelle
Publikováno v:
Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 7, Pp n/a-n/a (2021)
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 7, Pp n/a-n/a (2021)
Background Existing adult patient pharmacokinetic (PK) data from the published Advate vs Kovaltry PK crossover study were used for this validation study. This data set is appropriate for qualification, given that it has not been previously submitted
Duration analysis in longitudinal studies with intermittent observation times and losses to followup
Autor:
Jerald F. Lawless, Dagmar M. Hajducek
Publikováno v:
Canadian Journal of Statistics. 40:1-21
We consider the analysis of spell durations observed in event history studies where members of the study panel are seen intermittently. Challenges for analysis arise because losses to followup are frequently related to previous event history, and spe
Autor:
Paul A. Spagnuolo, Erica L. Lowthers, Cynthia L. Richard, Jonathan Blay, Dagmar M. Hajducek, Murray J. Cutler
Publikováno v:
BMC Cancer
Background Recurrence of colorectal cancer (CRC) may arise due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to chemotherapy. Proteins responsible for this recurrence include the chemokine receptor CXCR4, whic
Autor:
Paul A. Spagnuolo, Dagmar M. Hajducek, Erica L. Lowthers, Cynthia L. Richard, Jonathan Blay, Murray J. Cutler
Publikováno v:
Clinical Cancer Research. 21:B06-B06
Conventional chemotherapy eliminates the bulk of colorectal cancer (CRC) following surgery. However, recurrence may occur due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to the chemotherapeutic agents. The r
Autor:
Hajducek, Dagmar M.1 (AUTHOR), Chelle, Pierre1 (AUTHOR), Hermans, Cedric2 (AUTHOR), Iorio, Alfonso3 (AUTHOR), McEneny‐King, Alanna1 (AUTHOR), Yu, Jacky1 (AUTHOR), Edginton, Andrea1 (AUTHOR) aedginto@uwaterloo.ca
Publikováno v:
Haemophilia. May2020, Vol. 26 Issue 3, p384-400. 17p. 2 Diagrams, 3 Charts, 1 Graph.
Publikováno v:
Clinical Pharmacokinetics; Jul2022, Vol. 61 Issue 7, p997-1012, 16p