Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Dagmar Heydeck"'
Autor:
Florian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-25 (2023)
Abstract Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been implicated in inflammatory processes. Seven intact Alox genes have been detected in the mouse reference genome and the mouse Alox15 ge
Externí odkaz:
https://doaj.org/article/7c83cbe123094749a3d3a36998b23f6e
Autor:
Bernhard Dumoulin, Dagmar Heydeck, Desiree Jähn, Moritz Lassé, Sajad Sofi, Christoph Ufer, Hartmut Kuhn
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The guanine-rich RNA sequence binding factor 1 (GRSF1) is an RNA-binding protein of the heterogenous nuclear ribonucleoprotein H/F (hnRNP H/F) family that binds to guanine-rich RNA sequences forming G-quadruplex structures. In mice and human
Externí odkaz:
https://doaj.org/article/89779ebe5f85492f9caae2074e54b6eb
Autor:
Sophie Roigas, Kumar R. Kakularam, Michael Rothe, Dagmar Heydeck, Polamarasetty Aparoy, Hartmut Kuhn
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14154 (2023)
The human genome involves six functional arachidonic acid lipoxygenase (ALOX) genes and the corresponding enzymes (ALOX15, ALOX15B, ALOX12, ALOX12B, ALOXE3, ALOX5) have been implicated in cell differentiation and in the pathogenesis of inflammatory,
Externí odkaz:
https://doaj.org/article/e72034ee2d2341fdb90dd246eeebf133
Autor:
Marjann Schäfer, Florian Reisch, Dominika Labuz, Halina Machelska, Sabine Stehling, Gerhard P. Püschel, Michael Rothe, Dagmar Heydeck, Hartmut Kuhn
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11034 (2023)
Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in the pathogenesis of inflammatory diseases, and its pro- and anti-inflammatory effects have been reported for different ALOX-isoforms. Human ALOX15B oxygenates arachidonic acid t
Externí odkaz:
https://doaj.org/article/9dea358c140149189ab9d2eb5e3daf46
Autor:
Dagmar Heydeck, Christoph Ufer, Kumar R. Kakularam, Michael Rothe, Thomas Liehr, Philippe Poulain, Hartmut Kuhn
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4815 (2023)
Arachidonic acid lipoxygenases (ALOX) have been implicated in the pathogenesis of inflammatory, hyperproliferative, neurodegenerative, and metabolic diseases, but the physiological function of ALOX15 still remains a matter of discussion. To contribut
Externí odkaz:
https://doaj.org/article/0dc87f90315646e2b831a2c00bbe29de
Autor:
Dagmar Heydeck, Florian Reisch, Marjann Schäfer, Kumar R. Kakularam, Sophie A. Roigas, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Arachidonic acid lipoxygenases (ALOXs) have been implicated in the immune response of mammals. The reaction specificity of these enzymes is decisive for their biological functions and ALOX classification is based on this enzyme property. Comparing th
Externí odkaz:
https://doaj.org/article/d7a0cbd7c8b047e3a19fcbce56db8b3f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 16026 (2022)
Eicosanoids and related compounds are pleiotropic lipid mediators, which are biosynthesized in mammals via three distinct metabolic pathways (cyclooxygenase pathway, lipoxygenase pathway, epoxygenase pathway). These mediators have been implicated in
Externí odkaz:
https://doaj.org/article/3c4c11052e5d4c5b9dab5ebe3fd1a637
Autor:
Kumar Reddy Kakularam, Felix Karst, Aparoy Polamarasetty, Igor Ivanov, Dagmar Heydeck, Hartmut Kuhn
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112434- (2022)
Lipoxygenases (ALOX-isoforms) are lipid peroxidizing enzymes, which have been implicated in cell differentiation and maturation but also in the biosynthesis of lipid mediators playing important roles in the pathogenesis of inflammatory, hyperprolifer
Externí odkaz:
https://doaj.org/article/ceedff28c8c34ca48c9278f1abd92056
Autor:
Marjann Schäfer, Kumar R. Kakularam, Florian Reisch, Michael Rothe, Sabine Stehling, Dagmar Heydeck, Gerhard P. Püschel, Hartmut Kuhn
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1379 (2022)
Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid con
Externí odkaz:
https://doaj.org/article/c1e651eeeda34a91864c162c101576b8
Autor:
Eugenia Marbach-Breitrück, Nadine Rohwer, Carmen Infante-Duarte, Silvina Romero-Suarez, Dominika Labuz, Halina Machelska, Laura Kutzner, Nils Helge Schebb, Michael Rothe, Pallu Reddanna, Karsten H. Weylandt, Lothar H. Wieler, Dagmar Heydeck, Hartmut Kuhn
Publikováno v:
Metabolites, Vol 11, Iss 10, p 698 (2021)
Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachidonic acid 15-lipoxygenating Alox5 mutant instead of the 5-lipoxygenat
Externí odkaz:
https://doaj.org/article/b38f815a74e244eb91e567f76b5d8645