Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Dagmar Hönack"'
Publikováno v:
Brain Research. 735:208-216
Levetiracetam ((S)-α-ethyl -2-oxo-pyrrolidine acetamide, ucb L059) is a novel anticonvulsant drug presently in clinical development. Its mechanism of action is unknown although a recently reported novel specific binding site for [3H]levetiracetam, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aea5ac6b49df13b1ece4b076328b66
https://doi.org/10.1016/0006-8993(96)00587-2
https://doi.org/10.1016/0006-8993(96)00587-2
Autor:
Wolfgang Löscher, Dagmar Hönack
Publikováno v:
European Journal of Pharmacology. 299:61-67
The antiepileptic drug valproate has previously been shown to increase serotonin and dopamine turnover in certain brain regions, but the role of these alterations in the diverse pharmacodynamic effects of valproate is not known. For instance, monoami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ea61cd1cf47d66e569452bb08a84df
https://doi.org/10.1016/0014-2999(95)00831-4
https://doi.org/10.1016/0014-2999(95)00831-4
Publikováno v:
European Journal of Pharmacology. 286:167-175
The endogenous neuroinhibitory and neuroprotective excitatory amino acid receptor antagonist kynurenic acid has been hypothetically linked to the pathogenesis of epilepsy and several other brain disorders. In the present study, alterations in kynuren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799b00e50d53467bf056ed8e9b2e7383
https://doi.org/10.1016/0014-2999(95)00443-o
https://doi.org/10.1016/0014-2999(95)00443-o
Autor:
Dagmar Hönack, Wolfgang Löscher
Publikováno v:
Epilepsia. 36:929-937
Recently, sustained-release (SR) preparations of valproate (VPA) have been developed to minimize or prevent problems associated with plasma level fluctuations during therapy with conventional preparations. In the present experiments, the anticonvulsa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825633ce0c6abc46ec90753245c1c1d2
https://doi.org/10.1111/j.1528-1157.1995.tb01637.x
https://doi.org/10.1111/j.1528-1157.1995.tb01637.x
Publikováno v:
British Journal of Pharmacology. 112:97-106
1. The effects of the glycine/NMDA receptor partial agonists, D-cycloserine and (+)-HA-966 and the full agonist, D-serine, on focal seizure threshold and behaviour have been determined in amygdala-kindled rats, i.e. a model of focal (partial) epileps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79e6fa836aad35fc71d0e4b4ab7cd01
https://doi.org/10.1111/j.1476-5381.1994.tb13036.x
https://doi.org/10.1111/j.1476-5381.1994.tb13036.x
Publikováno v:
European Journal of Neuroscience. 5:1545-1550
Excitatory amino acid transmitters are involved in the initiation of seizures and their propagation. Most attention has been directed to synapses using N-methyl-D-aspartate (NMDA) receptors, although more recent evidence indicates potential roles for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a60ca8e252b38407ccc8cb3567a251
https://doi.org/10.1111/j.1460-9568.1993.tb00224.x
https://doi.org/10.1111/j.1460-9568.1993.tb00224.x
Publikováno v:
Neurochemical Research. 18:775-781
Kindling is a chronic model of epilepsy characterized by a progressive increase in response to the same regularly applied stimulus. The biological basis of the kindling phenomenon requires to be determined, but several studies indicate that alteratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea110342301c87562fa6da0c349c22f4
https://doi.org/10.1007/bf00966772
https://doi.org/10.1007/bf00966772
Autor:
Wolfgang Löscher, Dagmar Hönack
Publikováno v:
European Journal of Pharmacology. 234:237-245
The effects of combined treatment with low doses (1–5 mg/kg i.p.) of the competitive NMDA receptor antagonist, CGP 37849 (DL-[E]-2-amino-4-methyl-5-phosphono-3-pentenoic acid), and the antiepileptic drug, valproate, were studied in amygdala-kindled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58d939f09666e024a546d13d73d4827
https://doi.org/10.1016/0014-2999(93)90959-l
https://doi.org/10.1016/0014-2999(93)90959-l
Publikováno v:
European Journal of Pharmacology. 222:273-278
The effects of combined treatment with low doses (0.025-0.05 mg/kg i.p.) of the non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), and the antiepileptic drug, valproate, were studied in amygdala-kindled and non-kindled rats. MK-801, 0.05
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5f43470f1c9c7730c57f0ba0e64f3f
https://doi.org/10.1016/0014-2999(92)90866-3
https://doi.org/10.1016/0014-2999(92)90866-3
Publikováno v:
Neurochemical Research. 17:973-977
Concentrations of 11 amino acids, including the neurotransmitters GABA, glutamate, aspartate, glycine and taurine, were determined in 12 brain regions of female rats during different stages of the estrous cycle. In addition, amino acids and sex hormo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e971f08beaec85b008fd3f9c7225c576
https://doi.org/10.1007/bf00966823
https://doi.org/10.1007/bf00966823