Výsledky vyhledávání - "Dagmar Grittner"

Synthesis of Benzofuran, Benzothiophene, and Benzothiazole-Based Thioamides and their Evaluation as KATP Channel Openers

Autor: Claas Schmidt, Walter Frank, Thomas J. Wrobel, Stefan Lachenicht, Marcus Winkler, Horst Lemoine, Achim Rood, Andreas Fischer, Manfred Braun, Dagmar Grittner

Publikováno v: ChemMedChem. 5:1749-1759

Several series of benzofurans, benzothiophenes, and benzothiazoles, all featuring the thioamide group, were synthesized and tested as novel K(ATP) channel openers in artificial cell systems: CHO cells transfected with SUR1/Kir6.2, and HEK 293 cells t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795699c4571c2e0d20d03b92f1ce0d2b
https://doi.org/10.1002/cmdc.201000297

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Binding studies and GRIND/ALMOND-based 3D QSAR analysis of benzothiazine type K-ATP channel openers

Autor: Horst Lemoine, Emanuele Carosati, Stefano Sabatini, Roberto Spogli, Violetta Cecchetti, Raimund Mannhold, Dagmar Grittner, Oriana Tabarrini

For seventeen 1,4-benzothiazine potassium channel openers, we performed binding studies in rat aortic smooth muscle cells and cardiomyocytes, compared their binding affinities with published relaxation data, and derived 3D-QSAR models using GRIND/ALM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba799274a26ebd20751217465ac49b1
http://hdl.handle.net/11391/152589

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