Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dagmar Aichele"'
Autor:
Priscila López-Rojas, Samer Haidar, Franziska M. Jürgens, Dagmar Aichele, Ángel Amesty, Ana Estévez-Braun, Joachim Jose
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 100997- (2023)
Human protein kinase CK2 is an important target for the development of anticancer drugs. Many inhibitors were developed in the last few decades, among them emodin, a natural inhibitor with anthracene-9,10-dione backbone. In this work the inhibitory a
Externí odkaz:
https://doaj.org/article/edbe43404e6b4e7a8f8a8da04a8ee2f6
Autor:
Robin Birus, Ehab El‐Awaad, Laurens Ballentin, Faten Alchab, Dagmar Aichele, Laurent Ettouati, Claudia Götz, Marc Le Borgne, Joachim Jose
Publikováno v:
FEBS Open Bio, Vol 12, Iss 2, Pp 394-411 (2022)
Highly pleiotropic and constitutively active protein kinase CK2 is a key target in cancer therapy, but only one small‐molecule inhibitor has reached clinical trials—CX‐4945. In this study, we present the indeno[1,2‐b]indole derivative 5‐iso
Externí odkaz:
https://doaj.org/article/15575243169d4b53b3bcf241add65617
Autor:
Samer Haidar, Franziska M. Jürgens, Dagmar Aichele, Annika Jagels, Hans-Ulrich Humpf, Joachim Jose
Publikováno v:
Molecules, Vol 26, Iss 15, p 4453 (2021)
A large number of secondary metabolites have been isolated from the filamentous fungus Stachybotrys chartarum and have been described before. Fourteen of these natural compounds were evaluated in vitro in the present study for their inhibitory activi
Externí odkaz:
https://doaj.org/article/8480c8d81b4f4dd6803f33abe9dda6cd
Autor:
Ehab El-Awaad, Robin Birus, Christelle Marminon, Zouhair Bouaziz, Laurens Ballentin, Dagmar Aichele, Marc Le Borgne, Joachim Jose
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 542 (2021)
Protein kinase CK2 is involved in regulating cellular processes, such as cell cycle, proliferation, migration, and apoptosis, making it an attractive anticancer target. We previously described a prenyloxy-substituted indeno[1,2-b]indole (5-isopropyl-
Externí odkaz:
https://doaj.org/article/ab7f35e8a13441e3bcc8e494b0f4033a
Autor:
Samer Haidar, Christelle Marminon, Dagmar Aichele, Abdelhamid Nacereddine, Wael Zeinyeh, Abdeslem Bouzina, Malika Berredjem, Laurent Ettouati, Zouhair Bouaziz, Marc Le Borgne, Joachim Jose
Publikováno v:
Molecules, Vol 25, Iss 1, p 97 (2019)
Casein kinase II (CK2) is an intensively studied enzyme, involved in different diseases, cancer in particular. Different scaffolds were used to develop inhibitors of this enzyme. Here, we report on the synthesis and biological evaluation of twenty ph
Externí odkaz:
https://doaj.org/article/cead735122584236b050184220a83eb4
Autor:
Samer Haidar, Dagmar Aichele, Robin Birus, Janine Hielscher, Tuomo Laitinen, Antti Poso, Joachim Jose
Publikováno v:
Molecules, Vol 24, Iss 7, p 1380 (2019)
Protein kinase CK2 is an emerging target for therapeutic intervention in human diseases, particularly in cancer. Inhibitors of this enzyme are currently in clinical trials, indicating the druggability of human CK2. By virtual screening of the ZINC da
Externí odkaz:
https://doaj.org/article/d5abb7f1977c480585b9520c034aa10d
Autor:
Jennifer Hochscherf, Dirk Lindenblatt, Benedict Witulski, Robin Birus, Dagmar Aichele, Christelle Marminon, Zouhair Bouaziz, Marc Le Borgne, Joachim Jose, Karsten Niefind
Publikováno v:
Pharmaceuticals, Vol 10, Iss 4, p 98 (2017)
Protein kinase CK2, a member of the eukaryotic protein kinase superfamily, is associated with cancer and other human pathologies and thus an attractive drug target. The indeno[1,2-b]indole scaffold is a novel lead structure to develop ATP-competitive
Externí odkaz:
https://doaj.org/article/24ad668a92c94b90ade934644a046d63
Autor:
Ehab El-Awaad, Robin Birus, Laurens Ballentin, Faten Alchab, Dagmar Aichele, Laurent Ettouati, Claudia Götz, Marc Le Borgne, Joachim Jose
Publikováno v:
Proceedings of 7th International Electronic Conference on Medicinal Chemistry.
Autor:
Annika Jagels, Samer Haidar, Joachim Jose, Hans-Ulrich Humpf, Dagmar Aichele, Franziska M Jürgens
Publikováno v:
Molecules, Vol 26, Iss 4453, p 4453 (2021)
Molecules
Volume 26
Issue 15
Molecules
Volume 26
Issue 15
A large number of secondary metabolites have been isolated from the filamentous fungus Stachybotrys chartarum and have been described before. Fourteen of these natural compounds were evaluated in vitro in the present study for their inhibitory activi
Autor:
Marc Le Borgne, Christelle Marminon, Laurent Ettouati, Marine Ousset, Solène Audebert, Marc Rolland de Ravel, J. Jose, Noël Pinaud, Faten Alchab, Dagmar Aichele, Samer Haidar, Zouhair Bouaziz, Jean Guillon, Robin Birus
Publikováno v:
Proceedings of 6th International Electronic Conference on Medicinal Chemistry.