Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Dagmar Wilhelm"'
Autor:
Moïra Rossitto, Stephanie Déjardin, Chris M. Rands, Stephanie Le Gras, Roberta Migale, Mahmoud-Reza Rafiee, Yasmine Neirijnck, Alain Pruvost, Anvi Laetitia Nguyen, Guillaume Bossis, Florence Cammas, Lionel Le Gallic, Dagmar Wilhelm, Robin Lovell-Badge, Brigitte Boizet-Bonhoure, Serge Nef, Francis Poulat
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Gonadal fate in mammals is determined during embryogenesis and is actively maintained in adulthood. This study shows that E3-SUMO ligase activity of TRIM28 is required for ovarian identity maintenance and testicular-specific gene repression in mouse
Externí odkaz:
https://doaj.org/article/ee83c64ad8d44323a3713a98d8b88a59
Autor:
Simon P. Windley, Chloé Mayère, Alice E. McGovern, Natasha L. Harvey, Serge Nef, Quenten Schwarz, Sharad Kumar, Dagmar Wilhelm
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-10 (2022)
Abstract Gonadogenesis is the process wherein two morphologically distinct organs, the testis and the ovary, arise from a common precursor. In mammals, maleness is driven by the expression of Sry. SRY subsequently upregulates the related family membe
Externí odkaz:
https://doaj.org/article/fd032d7d056f42379b4180e4adc95403
Autor:
Stefan Bagheri-Fam, Huijun Chen, Sean Wilson, Katie Ayers, James Hughes, Frederique Sloan-Bena, Pierre Calvel, Gorjana Robevska, Beatriz Puisac, Kamila Kusz-Zamelczyk, Stefania Gimelli, Anna Spik, Jadwiga Jaruzelska, Alina Warenik-Szymankiewicz, Sultana Faradz, Serge Nef, Juan Pié, Paul Thomas, Andrew Sinclair, Dagmar Wilhelm
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227411 (2020)
Disorders/differences of sex development (DSD) cause profound psychological and reproductive consequences for the affected individuals, however, most are still unexplained at the molecular level. Here, we present a novel gene, 3-hydroxy-3-methylgluta
Externí odkaz:
https://doaj.org/article/1d69a154859b4aa693da7b441971531f
Autor:
Manfred Schartl, Susanne Schories, Yuko Wakamatsu, Yusuke Nagao, Hisashi Hashimoto, Chloé Bertin, Brigitte Mourot, Cornelia Schmidt, Dagmar Wilhelm, Lazaro Centanin, Yann Guiguen, Amaury Herpin
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-17 (2018)
Abstract Background Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of sex-determining genes within a network, by neo- or sub-functionalization, also requi
Externí odkaz:
https://doaj.org/article/d2e711a503d541508902dfa7584ed90c
Autor:
Amaury Herpin, Cornelia Schmidt, Susanne Kneitz, Clara Gobé, Martina Regensburger, Aurélie Le Cam, Jérome Montfort, Mateus C Adolfi, Christina Lillesaar, Dagmar Wilhelm, Michael Kraeussling, Brigitte Mourot, Béatrice Porcon, Maëlle Pannetier, Eric Pailhoux, Laurence Ettwiller, Dirk Dolle, Yann Guiguen, Manfred Schartl
Publikováno v:
PLoS Biology, Vol 17, Iss 4, p e3000185 (2019)
Dmrt1 is a highly conserved transcription factor, which is critically involved in regulation of gonad development of vertebrates. In medaka, a duplicate of dmrt1-acting as master sex-determining gene-has a tightly timely and spatially controlled gona
Externí odkaz:
https://doaj.org/article/2395a9041a7d47ae9747797b26d8574e
Autor:
Anqi Fu, Sydney M Oberholtzer, Stefan Bagheri-Fam, Raphael H Rastetter, Claire Holdreith, Valeria L Caceres, Steven V John, Sarah A Shaw, Kathleen J Krentz, Xiaoyun Zhang, Chi-Chung Hui, Dagmar Wilhelm, Joan S Jorgensen
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007488 (2018)
Women and other mammalian females are born with a finite supply of oocytes that determine their reproductive lifespan. During fetal development, individual oocytes are enclosed by a protective layer of granulosa cells to form primordial follicles tha
Externí odkaz:
https://doaj.org/article/10d4f1998aaa4d66826613474a5d568e
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170576 (2017)
Fetal germ cell development is tightly regulated by the somatic cell environment, and is characterised by cell cycle states that differ between XY and XX gonads. In the testis, gonocytes enter G1/G0 arrest from 12.5 days post coitum (dpc) in mice and
Externí odkaz:
https://doaj.org/article/ae72dcc3b78d434eb6c7e66dd13b8499
Publikováno v:
Human reproduction (Oxford, England). 37(9)
STUDY QUESTIONWhat is the effect of the ketone β-hydroxybutyrate (βOHB) on preimplantation mouse embryo development, metabolism, epigenetics and post-transfer viability?SUMMARY ANSWERIn vitro βOHB exposure at ketogenic diet (KD)-relevant serum con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc859ee117b8c6b435815ce0167c709a
https://pubmed.ncbi.nlm.nih.gov/35856159
https://pubmed.ncbi.nlm.nih.gov/35856159
Autor:
Robin Lovell-Badge, Francis Poulat, Moïra Rossitto, Le Gallic L, Dagmar Wilhelm, Alain Pruvost, Brigitte Boizet-Bonhoure, Legras S, Mahmoud-Reza Rafiee, Florence Cammas, Migale R, Serge Nef, Yasmine Neirijnck, Anvi Laetitia Nguyen, Guillaume Bossis, Chris M Rands, Stéphanie Déjardin
Publikováno v:
Nature Communications
Nature Communications, 2022, 13 (1), pp.4412. ⟨10.1038/s41467-022-32061-1⟩
Nature Communications, 2022, 13 (1), pp.4412. ⟨10.1038/s41467-022-32061-1⟩
Summary Gonadal sexual fate in mammals is determined during embryonic development and must be actively maintained in adulthood. Therefore, gonadal sex-specific transcription factors are required to prevent transdifferentiation of gonadal somatic cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701685a72d923123f981511d911cb902
Autor:
Patrick Callier, Pierre Calvel, Armine Matevossian, Periklis Makrythanasis, Pascal Bernard, Hiroshi Kurosaka, Anne Vannier, Christel Thauvin-Robinet, Christelle Borel, Séverine Mazaud-Guittot, Antoine Rolland, Christèle Desdoits-Lethimonier, Michel Guipponi, Céline Zimmermann, Isabelle Stévant, Françoise Kuhne, Béatrice Conne, Federico Santoni, Sandy Lambert, Frederic Huet, Francine Mugneret, Jadwiga Jaruzelska, Laurence Faivre, Dagmar Wilhelm, Bernard Jégou, Paul A Trainor, Marilyn D Resh, Stylianos E Antonarakis, Serge Nef
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004340 (2014)
The Hedgehog (Hh) family of secreted proteins act as morphogens to control embryonic patterning and development in a variety of organ systems. Post-translational covalent attachment of cholesterol and palmitate to Hh proteins are critical for multime
Externí odkaz:
https://doaj.org/article/639ab364e74943b08783e497d9a164d0