Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Dagmar, Tolenaars"'
1
Akademický článek
Laminin 511-E8, an autoantigen in IgG4-related cholangitis, contributes to cholangiocyte protection
Autor: David C. Trampert, Remco Kersten, Dagmar Tolenaars, Aldo Jongejan, Stan F.J. van de Graaf, Ulrich Beuers
Publikováno v: JHEP Reports, Vol 6, Iss 4, Pp 101015- (2024)
Background & Aims: IgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease. Anti-laminin 511-E8 autoantibodies have been identified in its pancreatic manifestation. Laminin 511-E8 promotes endothelial barrier functio
Externí odkaz: https://doaj.org/article/34909bddea67473eac8e116e50b64353
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2
Akademický článek
Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids
Autor: Remco Kersten, David C. Trampert, Lowiek M. Hubers, Dagmar Tolenaars, Harmjan R. Vos, Stan F. J. van de Graaf, Ulrich Beuers
Publikováno v: Frontiers in Immunology, Vol 14 (2024)
Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder. Four autoantigens have recently been described in IgG4-RD: annexin A11, galectin-3, la
Externí odkaz: https://doaj.org/article/9a8c0afbbd31453fad841b7992688e02
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3
Akademický článek
An LPAR5-antagonist that reduces nociception and increases pruriception
Autor: Jacqueline Langedijk, Erika Ivanna Araya, Amanda Ribeiro Barroso, Dagmar Tolenaars, Marc Nazaré, Hassane Belabed, Jens Schoene, Juliana Geremias Chichorro, Ronald Oude Elferink
Publikováno v: Frontiers in Pain Research, Vol 3 (2022)
IntroductionThe G-protein coupled receptor LPAR5 plays a prominent role in LPA-mediated pain and itch signaling. In this study we focus on the LPAR5-antagonist compound 3 (cpd3) and its ability to affect pain and itch signaling, both in vitro and in
Externí odkaz: https://doaj.org/article/b57a9af173bd488d918cfb9ed75bd1f1
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4
Akademický článek
Reduced spontaneous itch in mouse models of cholestasis
Autor: Jacqueline Langedijk, Ruth Bolier, Dagmar Tolenaars, Lysbeth ten Bloemendaal, Suzanne Duijst, Dirk de Waart, Ulrich Beuers, Piter Bosma, Ronald Oude Elferink
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Pruritus is one of the most distressing symptoms in cholestatic patients. Plasma autotaxin (ATX) activity correlates with the severity of pruritus in cholestatic patients, but the pathophysiology is unclear. To study pruritus in mice, we mea
Externí odkaz: https://doaj.org/article/8a91086451c548c488f3ed16188f6c17
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5
Akademický článek
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
Autor: Willem-Jan Keune, Jens Hausmann, Ruth Bolier, Dagmar Tolenaars, Andreas Kremer, Tatjana Heidebrecht, Robbie P. Joosten, Manjula Sunkara, Andrew J. Morris, Elisa Matas-Rico, Wouter H. Moolenaar, Ronald P. Oude Elferink, Anastassis Perrakis
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as r
Externí odkaz: https://doaj.org/article/2ccdbeab88fd47eba8cb69bd11c92811
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6
An LPAR
Autor: Jacqueline, Langedijk, Erika Ivanna, Araya, Amanda Ribeiro, Barroso, Dagmar, Tolenaars, Marc, Nazaré, Hassane, Belabed, Jens, Schoene, Juliana Geremias, Chichorro, Ronald, Oude Elferink
Publikováno v: Frontiers in pain research (Lausanne, Switzerland). 3
The G-protein coupled receptor LPARNociceptive behavior in wild type mice was induced by formalin, carrageenan or prostaglandin E2 (PGEAs expected, nociceptive behavior (induced by formalin, carrageenan or PGECpd3 has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7fbe3cc2bad7f79e17f857c72b943a97
https://pubmed.ncbi.nlm.nih.gov/35959236
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8
Inhibition of autotaxin by bile salts and bile salt-like molecules increases its expression by feedback regulation
Autor: Jacqueline Langedijk, Ruth Bolier, Yi-Té Lee, Ronald P.J. Oude Elferink, Catherine Williamson, Stan F.J. van de Graaf, Luciano Adorini, Amber Meurs, Ulrich Beuers, Dagmar Tolenaars
Publikováno v: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1867(11):166239. Elsevier
Background Autotaxin is an enzyme that converts lysophospholipid into lysophosphatidic acid (LPA), a highly potent signaling molecule through a range of LPA receptors. It is therefore important to investigate which factors play a role in regulating A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b38fc1c41728073d30ba677708de030
https://pure.amc.nl/en/publications/inhibition-of-autotaxin-by-bile-salts-and-bile-saltlike-molecules-increases-its-expression-by-feedback-regulation(9153cc2d-8e9d-4f4f-a81e-be7e90966f92).html
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9
Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection
Autor: Michael H. Nathanson, Lowiek M. Hubers, Stan F.J. van de Graaf, Ronald P.J. Oude Elferink, Coen C. Paulusma, Ulrich Beuers, Jung-Chin Chang, Remco Kersten, Simei Go, Dagmar Tolenaars, Toni Herta
Publikováno v: Herta, T, Kersten, R, Chang, J-C, Hubers, L, Go, S, Tolenaars, D, Paulusma, C C, Nathanson, M H, Elferink, R O, van de Graaf, S F J & Beuers, U 2022, ' Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection ', Journal of Hepatology, vol. 76, no. 2, pp. 319-331 . https://doi.org/10.1016/j.jhep.2021.10.009
Journal of hepatology, 76(2), 319-331. Elsevier
Journal of Hepatology, 76(2), 319-331. Elsevier
Background & aims Annexin A11 was identified as autoantigen in IgG4-related cholangitis (IRC), a B-cell driven disease. Annexin A11 modulates calcium-dependent exocytosis, a crucial mechanism for insertion of proteins into their target membranes. Hum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f1e29b9fd4355163077ffd33b9f300
https://pubmed.ncbi.nlm.nih.gov/34718050
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10
Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice
Autor: Ulrich Beuers, Takeshi Katafuchi, Davor Slijepcevic, Reinout L.P. Roscam Abbing, Joanne M. Donkers, Jonathan H. M. van der Meer, Alfred H. Schinkel, Stéphanie van Hoppe, Ronald P.J. Oude Elferink, Manon E. Wildenberg, Stan F.J. van de Graaf, Dagmar Tolenaars, Antje Blank, Dirk R. de Waart
Publikováno v: Hepatology (Baltimore, Md.)
Hepatology (Baltimore, Md.), 66(5), 1631-1643. John Wiley and Sons Ltd
The Na+ -taurocholate cotransporting polypeptide (NTCP/SLC10A1) is believed to be pivotal for hepatic uptake of conjugated bile acids. However, plasma bile acid levels are normal in a subset of NTCP knockout mice and in mice treated with myrcludex B,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddc97957feda7711cd00c28580a24c1
http://europepmc.org/articles/PMC5698707
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