Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Dagmar, Pretsch"'
Autor:
Julia Zwirchmayr, Benjamin Kirchweger, Theresa Lehner, Ammar Tahir, Dagmar Pretsch, Judith M. Rollinger
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract In this study a robust, whole organism screening based on Caenorhabditis elegans is presented for the discovery of natural products (NP) with beneficial effects against obesity and age-related diseases. Several parameters of the elaborated w
Externí odkaz:
https://doaj.org/article/07fdb2401ccd4e7abf75d0a961d73f3b
Autor:
Benjamin Kirchweger, Luiz C. Klein-Junior, Dagmar Pretsch, Ya Chen, Sylvian Cretton, André L. Gasper, Yvan Vander Heyden, Philippe Christen, Johannes Kirchmair, Amélia T. Henriques, Judith M. Rollinger
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Nemorosine A (1) and fargesine (2), the main azepine-indole alkaloids of Psychotria nemorosa, were explored for their pharmacological profile on neurodegenerative disorders (NDs) applying a combined in silico–in vitro–in vivo approach. By using 1
Externí odkaz:
https://doaj.org/article/6a8f1704be004251a23ef4db743ccbe3
Autor:
Lewis T. Ibbotson, Kirsten E. Christensen, Miroslav Genov, Alexander Pretsch, Dagmar Pretsch, Mark G. Moloney
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 9 (2022)
We report that phthalimides may be cyclized using a Mukaiyama-type aldol coupling to give variously substituted fused lactam (1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-a]isoindol-5-one) systems. This novel process shows a high level of regioselectivity for
Externí odkaz:
https://doaj.org/article/cae6ba287db44f8180a702f98b9edf4f
Autor:
Liban Saney, Kirsten E. Christensen, Miroslav Genov, Alexander Pretsch, Dagmar Pretsch, Mark G. Moloney
Publikováno v:
Organic & Biomolecular Chemistry. 21:4061-4071
Tetramates derived from phenylserines are obtained chemoselectively and diastereoselectively, and after derivatisation as their amides, in some cases exhibit excellent antibacterial activity against Gram-positive bacteria.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33e24ed606cf5e5270c7e7d24e8f5c0e
https://doi.org/10.1039/d3ob00376k
https://doi.org/10.1039/d3ob00376k
Autor:
Dagmar Pretsch
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 12, Pp 2388-2389 (2021)
Externí odkaz:
https://doaj.org/article/ec84cd6d56a34732b6aba2a7c2b8d8d0
Autor:
Liban Saney, Kirsten E. Christensen, Xiang Li, Miroslav Genov, Alexander Pretsch, Dagmar Pretsch, Mark G. Moloney
Publikováno v:
The Journal of Organic Chemistry. 87:12240-12249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::429d873569ca105052041e777c0a92c4
https://doi.org/10.1021/acs.joc.2c01382
https://doi.org/10.1021/acs.joc.2c01382
Skeletal Analogues of UCS1025A and B by Cyclization of Maleimides: Synthesis and Biological Activity
Autor:
Mark G. Moloney, Lewis T. Ibbotson, Kirsten E. Christensen, Miroslav Genov, Alexander Pretsch, Dagmar Pretsch
Publikováno v:
Synlett. 33:396-400
Application of a direct ring-closing approach which exploits an intramolecular aldol reaction with a ketene silyl acetal onto a remote imide function leading to the core skeleton of UCS1025A and B effectively provides access to small library of subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdafc795cbe357b557b06b1c611960a0
https://doi.org/10.1055/s-0040-1719876
https://doi.org/10.1055/s-0040-1719876
Autor:
Liban Saney, Tharindi Panduwawala, Xiang Li, Kirsten E. Christensen, Miroslav Genov, Alexander Pretsch, Dagmar Pretsch, Mark G. Moloney
Publikováno v:
Organic & Biomolecular Chemistry.
Chemoselective ring closure of malonamides gives oxazolidine- or imidazolidine fused tetramates, some of which show antibacterial activity against Gram positive organism; these occupy a well-defined region of chemical space.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64aa599590fddb1c42f5e3d26221a87e
https://doi.org/10.1039/d3ob00594a
https://doi.org/10.1039/d3ob00594a
Publikováno v:
Chemical Science
A study of bicyclic tetramates modified with a bulky ester, which leads to steric hindrance of distal chelating atoms as a route for the alteration of metal binding ability is reported. This approach required the development of a direct method for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1588646ec57a4ad3dbcd14a78a8bcc
https://doi.org/10.1039/d1sc05542a
https://doi.org/10.1039/d1sc05542a
Publikováno v:
The Journal of Organic Chemistry. 85:12393-12407
The synthesis, structural, and antibacterial evaluation of bicyclic tetramate derivatives of cysteine rendered hydrophilic with pendant heterocyclic substituents is reported; effective synthetic protocols and antibacterial activity for a small librar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f70e14cd21c6d8dfeb4cfdd367b7848
https://doi.org/10.1021/acs.joc.0c01636
https://doi.org/10.1021/acs.joc.0c01636