A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells

Autor: Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Kinsley Belle, Tamar Sapir, Fanuel Messaggio, Kevin B. Johnson, Oliver Umland, Darrell Hardin, Dagmar Klein, Ingrid Pérez-Álvarez, Fatima Sadiq, Oscar Alcázar, Luca A. Inverardi, Camillo Ricordi, Peter Buchwald, Christopher A. Fraker, Ricardo L. Pastori, Juan Domínguez-Bendala

Publikováno v: Stem Cell Reports, Vol 12, Iss 3, Pp 611-623 (2019)

Summary: The transplantation of human embryonic stem cell (hESC)-derived insulin-producing β cells for the treatment of diabetes is finally approaching the clinical stage. However, even with state-of-the-art differentiation protocols, a significant

Externí odkaz: https://doaj.org/article/4370bf27b2c441a0890f656127747865

Contributors

Autor: Ahmed Safwat Abouhashem, Aamir Ahmad, Shazia Ahmad, Saira R. Ali, Tyler Anderson, Daniele Avitabile, Asha Balakrishnan, Mumtaz Yaseen Balkhi, Bin Bao, Nasma Bastaki, Christophe Beclin, Soumaya Ben-Aicha, Andreas Bosio, Emily Bruch, George A. Calin, Yang Cao, Maurizio C. Capogrossi, Andrea Caporali, Derryn Xin Hui Chan, Yuk Cheung Chan, Pavithra L. Chavali, Sreenivas Chavali, Alex F. Chen, Xiaona Chen, Charles Cook, Harold Cremer, Catherine Czeisler, Duaa Dakhlallah, Amitava Das, Anne M. Delany, Dasa Dolezalova, Juan Domínguez-Bendala, Manar A. EI Naggar, Costanza Emanueli, Michael Ezzie, Sara T. Fathallah, Tiziana Franceschetti, Roberto Gambari, Subhadip Ghatak, Jonathan M. Gleadle, Le Luo Guan, Denis C. Guttridge, Patrick Edwin Gygli, Khawaja H. Haider, Aleš Hampl, Sen Han, Martin C. Harmsen, Yoshinori Hasegawa, Sara A. Hashish, Eric Hesse, John D. Houlé, Kazuki Inoue, Jared Jagdeo, Imran Khan, Mahmood Khan, Shirin Elizabeth Khorsandi, Dagmar Klein, Dejuan Kong, Guido Krenning, Praveen Kusumanchi, Yiwei Li, Zhigang Li, Suthat Liangpunsakul, Kenneth W. Liechty, Amanda Louiselle, Leina Lu, Alessandra Magenta, Nilusha Malmuthuge, Andrew Mamalis, Clay B. Marsh, Selina Möbus, Ganesh Mohan, Peter J. Mohler, Leni Moldovan, Paloma del C. Monroig, Marek Mraz, S. Patrick Nana-Sinkam, Colby R. Neumann, Stephen Niemiec, José Javier Otero, Durba Pal, Ricardo L. Pastori, Melissa G. Piper, Giulio Pompilio, Mirza Muhammed Fahd Qadir, Srinivas Ramsamy, Darling Rojas-Canales, Alessandra Rossini, Sashwati Roy, Yashika Rustagi, Alaa A. Salama, Mohamed Salama, Prabha Sampath, Fazlul H. Sarkar, Mitsuo Sato, Chandan K. Sen, David S. Shames, Amar Deep Sharma, Anjali Kumari Singh, Kanhaiya Singh, Mithun Sinha, Prashant Srivastava, Hao Sun, Yeqing Sun, Hidetoshi Tahara, Hanna Taipaleenmäki, Joanne Trgovich, Elise J. Tucker, Huating Wang, Jie-Mei Wang, Lijun Wang, Yijie Wang, Brandon Watson, Dan Xu, Junwang Xu, Yi Xuan, Dakai Yang, Zhihong Yang, Nouran Yonis, Marina E. Zambrotta, Carlos Zgheib, Ting Zhang, Baohong Zhao, Yu Zhao, Liang Zhou

Publikováno v: MicroRNA in Regenerative Medicine ISBN: 9780128207192

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25fcccc3661d4f1726e687aa5282c2ff
https://doi.org/10.1016/b978-0-12-820719-2.09992-0

Publisher Correction: Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

Autor: Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/2a1cc15a96f04c4e9605fe345f65874d

251-LB: Tracking Beta-Cell Regeneration in Human Pancreatic Slices using Adenovirus Transduction

Autor: SILVIA ALVAREZ-CUBELA, DAGMAR KLEIN, CHARLES G. ALVER, MIRZA MUHAMMAD FAHD QADIR, LUCIANA MATEUS GONCALVES, FARHAN QURESHI, JOANA ALMACA, CHRISTOPHER FRAKER, ALEJANDRO CAICEDO, ALBERTO PUGLIESE, CAMILLO RICORDI, ELISA OLTRA, ASHUTOSH G. AGARWAL, RICARDO PASTORI, JUAN DOMÍNGUEZ-BENDALA

Publikováno v: Diabetes. 71

Introduction: The study of pancreatic regeneration would benefit greatly from the design and validation of robust human-based models. Human Pancreatic Slices (HPSs) are thin organotypic sections of live pancreatic tissue. The sectioning method preser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ab35f62fc17727fe8d85f4a813d83d7
https://doi.org/10.2337/db22-251-lb

Population Pharmacokinetics and Pharmacodynamics of Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction

Autor: Matthias Frei, Corina Becker, Joachim Grevel, Lothar Roessig, Dirk Garmann, Rupert P. Austin, Michaela Meyer, Burkert Pieske, Dagmar Klein, Hauke Ruehs

Publikováno v: Clinical Pharmacokinetics

Background Vericiguat, a stimulator of soluble guanylate cyclase, has been developed as a first-in-class therapy for worsening chronic heart failure in adults with left ventricular ejection fraction < 45%. Objective The objective of this article was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060b376d3024cbe1cbc5c71300a70b49
https://pubmed.ncbi.nlm.nih.gov/34086190