Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Dagmar, Gotthardt"'
Autor:
Jana Trifinopoulos, Julia List, Thorsten Klampfl, Klara Klein, Michaela Prchal-Murphy, Agnieszka Witalisz-Siepracka, Florian Bellutti, Luca L. Fava, Gerwin Heller, Sarah Stummer, Patricia Testori, Monique L. den Boer, Judith M. Boer, Sonja Marinovic, Gregor Hoermann, Wencke Walter, Andreas Villunger, Piotr Sicinski, Veronika Sexl, Dagmar Gotthardt
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of cancer research
Externí odkaz:
https://doaj.org/article/8800b97f24a34ac584683af5d6db62a8
Autor:
Ulrike Schmidt, Betül Uluca, Iva Vokic, Barizah Malik, Thomas Kolbe, Caroline Lassnig, Martin Holcmann, Veronica Moreno-Viedma, Bernhard Robl, Carina Mühlberger, Dagmar Gotthardt, Maria Sibilia, Thomas Rülicke, Mathias Müller, Agnes Csiszar
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0286256 (2023)
FAM3C/ILEI is an important factor in epithelial-to-mesenchymal transition (EMT) induction, tumor progression and metastasis. Overexpressed in many cancers, elevated ILEI levels and secretion correlate with poor patient survival. Although ILEI's causa
Externí odkaz:
https://doaj.org/article/994b8dfe26b74aa0b5ce6ad114d089ef
Autor:
Vanessa Maria Knab, Dagmar Gotthardt, Klara Klein, Reinhard Grausenburger, Gerwin Heller, Ingeborg Menzl, Daniela Prinz, Jana Trifinopoulos, Julia List, Daniela Fux, Agnieszka Witalisz-Siepracka, Veronika Sexl
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Abstract Triple-negative breast cancer (TNBC) is an aggressive malignant disease that is responsible for approximately 15% of breast cancers. The standard of care relies on surgery and chemotherapy but the prognosis is poor and there is an urgent nee
Externí odkaz:
https://doaj.org/article/7325c12c85af4d8aae4f8418324ba67e
Autor:
Michal Sobecki, Ewelina Krzywinska, Shunmugam Nagarajan, Annette Audigé, Khanh Huỳnh, Julian Zacharjasz, Julien Debbache, Yann Kerdiles, Dagmar Gotthardt, Norihiko Takeda, Joachim Fandrey, Lukas Sommer, Veronika Sexl, Christian Stockmann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
During wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can
Externí odkaz:
https://doaj.org/article/95b70bae74314a89afad5e46b3247257
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural killer (NK) cells play an important role in recognizing and killing pathogen-infected or malignant cells. Changes in their numbers or activation can contribute to several diseases and pathologies including systemic sclerosis (SSc), an autoimm
Externí odkaz:
https://doaj.org/article/3141d0b45b80470da533df5c6780bf7b
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multiple sclerosis (MS) is a highly debilitating autoimmune disease affecting millions of individuals worldwide. Although classically viewed as T-cell mediated disease, the role of innate lymphoid cells (ILC) such as natural killer (NK) cells and ILC
Externí odkaz:
https://doaj.org/article/d450d5e5a7724c35b53108967c7753d0
Autor:
Klara Klein, Agnieszka Witalisz-Siepracka, Dagmar Gotthardt, Benedikt Agerer, Felix Locker, Reinhard Grausenburger, Vanessa Maria Knab, Andreas Bergthaler, Veronika Sexl
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The cyclin-dependent kinase 6 (CDK6) regulates the transition through the G1-phase of the cell cycle, but also acts as a transcriptional regulator. As such CDK6 regulates cell survival or cytokine secretion together with STATs, AP-1 or NF-κB. In the
Externí odkaz:
https://doaj.org/article/e189b33460474574be19851dc3ebbb58
Autor:
Ewelina Krzywinska, Chahrazade Kantari-Mimoun, Yann Kerdiles, Michal Sobecki, Takayuki Isagawa, Dagmar Gotthardt, Magali Castells, Johannes Haubold, Corinne Millien, Thomas Viel, Bertrand Tavitian, Norihiko Takeda, Joachim Fandrey, Eric Vivier, Veronika Sexl, Christian Stockmann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Tumour hypoxia influences both the immune responses and angiogenesis. Here, the authors show that HIF-1α deletion in NK cells impairs NK cytotoxic activity but inhibit tumour growth by decreasing the infiltration of NK cells that express angiostatic
Externí odkaz:
https://doaj.org/article/9fad3e202ec447b8825aaed0e43794af
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from hematopoietic stem cells (HSCs) that differentiate through commo
Externí odkaz:
https://doaj.org/article/fc64a471aeba43419dad15dc269ea241
Autor:
Veronika Sexl, Eva Maria Putz, Leo Edlinger, Daniela Prinz, Ingeborg Menzl, Zrinka Didara, Michaela Prchal-Murphy, Dagmar Gotthardt, Agnieszka Witalisz-Siepracka
S2. Quantification of perforin and granzyme B western blot from Fig. 2 and ex vivo cytotoxicity assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b40d4c17dc88004a65ec00739445aab
https://doi.org/10.1158/2326-6066.22539863.v1
https://doi.org/10.1158/2326-6066.22539863.v1
