Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

Autor: Lee, C.Y. Daniel, Daggett, Anthony, Gu, Xiaofeng, Jiang, Lu-Lin, Langfelder, Peter, Li, Xiaoguang, Wang, Nan, Zhao, Yingjun, Park, Chang Sin, Cooper, Yonatan, Ferando, Isabella, Mody, Istvan, Coppola, Giovanni, Xu, Huaxi, Yang, X. William

Publikováno v: In Neuron 7 March 2018 97(5):1032-1048

Novel Mice for Investigating Triggering Receptor Expressed on Myeloid Cells-2 (TREM2), an Alzheimer’s Disease-Linked Immune Gene That Alters Microglia Responses to Neurodegeneration

Autor: Daggett, Anthony Michael

Publikováno v: Daggett, Anthony Michael. (2016). Novel Mice for Investigating Triggering Receptor Expressed on Myeloid Cells-2 (TREM2), an Alzheimer’s Disease-Linked Immune Gene That Alters Microglia Responses to Neurodegeneration. UCLA: Neuroscience 004F. Retrieved from: http://www.escholarship.org/uc/item/4xc8870r

Triggering Receptor Expressed on Myeloid cells-2 (TREM2) is an immunoreceptor with genetic links to human neurodegenerative disorders. TREM2 is thought to alter the microglial response to neurodegeneration in a protective way. This dissertation descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::1bbee9faf320905960eb42e0f2bd9db7
http://www.escholarship.org/uc/item/4xc8870r

Author Correction: Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease

Autor: Wilton, Daniel K., Mastro, Kevin, Heller, Molly D., Gergits, Frederick W., Willing, Carly Rose, Fahey, Jaclyn B., Frouin, Arnaud, Daggett, Anthony, Gu, Xiaofeng, Kim, Yejin A., Faull, Richard L. M., Jayadev, Suman, Yednock, Ted, Yang, X. William, Stevens, Beth

Publikováno v: Nature Medicine; 20230101, Issue: Preprints p1-1, 1p

BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice.

Autor: Lee CYD, De La Rocha AJ, Inouye K, Langfelder P, Daggett A, Gu X, Jiang LL, Pamonag Z, Vaca RG, Richman J, Kawaguchi R, Gao F, Xu H, Yang XW

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 05. Date of Electronic Publication: 2023 Aug 05.