Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Dagan O. Lonsdale"'
Autor:
Reya V. Shah, Karin Kipper, Emma H. Baker, Charlotte I. S. Barker, Isobel Oldfield, Barbara J. Philips, Atholl Johnston, Jeffrey Lipman, Andrew Rhodes, Marina Basarab, Mike Sharland, Sarraa Almahdi, Rachel M. Wake, Joseph F. Standing, Dagan O. Lonsdale
Publikováno v:
Antibiotics, Vol 12, Iss 4, p 643 (2023)
Pharmacokinetics are highly variable in critical illness, and suboptimal antibiotic exposure is associated with treatment failure. Benzylpenicillin is a commonly used beta-lactam antibiotic, and pharmacokinetic data of its use in critically ill adult
Externí odkaz:
https://doaj.org/article/70a6c155d9134c97a03d401462c6a343
Autor:
Shan Pan, Teresa Tsakok, Nick Dand, Dagan O. Lonsdale, Floris C. Loeff, Karien Bloem, Annick deVries, David Baudry, Michael Duckworth, Satveer Mahil, Angela Pushpa‐Rajah, Alice Russell, Ali Alsharqi, Gabrielle Becher, Ruth Murphy, Shyamal Wahie, Andrew Wright, Christopher E.M. Griffiths, Nick J. Reynolds, Jonathan Barker, Richard B. Warren, A. David Burden, Theo Rispens, Joseph F. Standing, Catherine H. Smith, on behalf of the BADBIR Study Group, the BSTOP Study Group, the PSORT Consortium
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 400-409 (2020)
Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real‐world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first‐l
Externí odkaz:
https://doaj.org/article/619cb5f9e3a54af0aff4b70a0b891c13
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Sepsis secondary to bacterial infection remains a significant cause of morbidity and mortality globally. Recent decades have seen the evolution of international collaborations to improve care for these patients and identify areas for research. In thi
Externí odkaz:
https://doaj.org/article/27ef3f4b9fd9405c890afbb7af165d9a
Autor:
Akosua A. Agyeman, Tao You, Phylinda L. S. Chan, Dagan O. Lonsdale, Christoforos Hadjichrysanthou, Tabitha Mahungu, Emmanuel Q. Wey, David M. Lowe, Marc C. I. Lipman, Judy Breuer, Frank Kloprogge, Joseph F. Standing
Pharmacometric analyses of time series viral load data may detect drug effects with greater power than approaches using single time points. Because SARS-CoV-2 viral load rapidly rises and then falls, viral dynamic models have been used. We compared d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2b1c0db3117b20284437b7183e2aa8
Autor:
Frank Kloprogge, Simon J Carter, Judith Breuer, Joseph F. Standing, Florencia A.T. Boshier, Ivan Hung, Dagan O. Lonsdale, Mario Cortina-Borja, Juanita Pang, Silke Gastine
Publikováno v:
Clinical Pharmacology and Therapeutics
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral loads change rapidly following symptom onset, so to assess antivirals it is important to understand the natural history and patient factors influencing this. We undertook an individua
Autor:
Dagan O Lonsdale, Jeffrey Lipman
Publikováno v:
Expert Review of Precision Medicine and Drug Development. 6:87-93
Introduction: Sepsis from bacterial infection remains a significant cause of morbidity and mortality. Antibiotic use continues to increase in the community and secondary care. This is driven by the potential benefits to the individual patient of a co
Autor:
Andrew Rhodes, Isobel Oldfield, Charlotte I. S. Barker, Joseph F. Standing, Barbara J Philips, Dagan O. Lonsdale, Mike Sharland, Atholl Johnston, Emma H. Baker, Karin Kipper
Publikováno v:
Journal of Antimicrobial Chemotherapy. 75:3625-3634
BackgroundThe pharmacokinetics of β-lactam antibiotics in critical illness remain poorly characterized, particularly in neonates, children and the elderly. We undertook a pharmacokinetic study of commonly used β-lactam antibiotics in critically ill
Autor:
Dagan O Lonsdale, Liting Tong, Helen Farrah, Sarah Farnell-Ward, Chris Ryan, Ximena Watson, Maurizio Cecconi, Hans Flaatten, Jesper Fjølner, Christian Jung, Bertrand Guidet, Dylan de Lange, Wojciech Szczeklik, Johanna M Muessig, Susannah K Leaver
Publikováno v:
J Intensive Care Soc
Introduction The age of patients admitted into critical care in the UK is increasing. Clinical decisions for very-old patients, usually defined as over 80, can be challenging. Clinicians are frequently asked to predict outcomes as part of discussions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e7011d09512ebad0da50937d80666d
Publikováno v:
Current Infectious Disease Reports
Purpose of Review Sepsis is a leading cause of death worldwide. Groundbreaking international collaborative efforts have culminated in the widely accepted surviving sepsis guidelines, with iterative improvements in management strategies and definition
Autor:
Jeffrey Lipman, Jacobus P.J. Ungerer, Dagan O Lonsdale, Brett McWhinney, Amelia Livermore, Jason A. Roberts
Publikováno v:
Chemotherapy. 64:173-176
Dosing of amoxicillin-clavulanic acid in critical illness is difficult as β-lactam pharmacokinetics are altered by physiological changes and therapies initiated in the intensive care unit such as renal replacement therapy (RRT). Successful treatment