Dose rate dependent reduction in chromatin accessibility at transcriptional start sites long time after exposure to gamma radiation

Autor: Hildegunn Dahl, Jarle Ballangby, Torstein Tengs, Marcin W. Wojewodzic, Dag M. Eide, Dag Anders Brede, Anne Graupner, Nur Duale, Ann-Karin Olsen

Publikováno v: Epigenetics, Vol 18, Iss 1 (2023)

Ionizing radiation (IR) impact cellular and molecular processes that require chromatin remodelling relevant for cellular integrity. However, the cellular implications of ionizing radiation (IR) delivered per time unit (dose rate) are still debated. T

Externí odkaz: https://doaj.org/article/5736247f09b14050836f306f70c98184

Perturbed transcriptional profiles after chronic low dose rate radiation in mice.

Autor: Hildegunn Dahl, Dag M Eide, Torstein Tengs, Nur Duale, Jorke H Kamstra, Deborah H Oughton, Ann-Karin Olsen

Publikováno v: PLoS ONE, Vol 16, Iss 8, p e0256667 (2021)

Adverse health outcomes of ionizing radiation given chronically at low dose rates are highly debated, a controversy also relevant for other stressors. Increased knowledge is needed for a more comprehensive understanding of the damaging potential of i

Externí odkaz: https://doaj.org/article/2132da96afc74bc2abfd35a591543066

Calibration of the comet assay using ionising radiation

Autor: Gunnar Brunborg, Dag M. Eide, Anne Graupner, Kristine Gutzkow, Sergey Shaposhnikov, Marcin Kruszewski, Nikolai Sirota, George D.D. Jones, Gudrun Koppen, Filip Vanhavere, Peter Møller, Rudolf Stetina, Hildegunn Dahl, Andrew Collins

Publikováno v: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Brunborg, G, Eide, D M, Graupner, A, Gutzkow, K, Shaposhnikov, S, Kruszewski, M, Sirota, N, Jones, G D D, Koppen, G, Vanhavere, F, Møller, P, Stetina, R, Dahl, H & Collins, A 2023, ' Calibration of the comet assay using ionising radiation ', Mutation Research-Genetic Toxicology and Environmental Mutagenesis, vol. 885, 503560 . https://doi.org/10.1016/j.mrgentox.2022.503560

Several trials have attempted to identify sources of inter-laboratory variability in comet assay results, aiming at achieving more equal responses. Ionising radiation induces a defined level of DNA single-strand breaks (per dose/base pairs) and is us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f7ec16b7ec2df4a5244b04c9e7b2da
https://doi.org/10.1016/j.mrgentox.2022.503560

Adaptive tolerance to multigenerational silver nanoparticle (NM300K) exposure by the nematode Caenorhabditis elegans is associated with increased sensitivity to AgNO3

Autor: Dag Anders Brede, Erica Maremonti, Lisa M. Rossbach, Deborah Oughton, Dag M. Eide

Publikováno v: Nanotoxicology. 13:527-542

Toxic effects of silver nanoparticles (Ag NPs) are, in most cases, measured within a single generation, while information regarding multigenerational exposure remains scarce. The current study asse...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f817feef44e8566d4890f510fdc06c3b
https://doi.org/10.1080/17435390.2018.1557272

Adaptive tolerance to multigenerational silver nanoparticle (NM300K) exposure by the nematode

Autor: Lisa M, Rossbach, Erica, Maremonti, Dag M, Eide, Deborah H, Oughton, Dag A, Brede

Publikováno v: Nanotoxicology. 13(4)

Toxic effects of silver nanoparticles (Ag NPs) are, in most cases, measured within a single generation, while information regarding multigenerational exposure remains scarce. The current study assessed changes in toxic response (reproduction, fertili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba401554684cd610dafbc25d906f824f
https://pubmed.ncbi.nlm.nih.gov/30773089