Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Dafne Ruggiero"'
Autor:
Alessandra Capuano, Gilda D’Urso, Michela Aliberti, Dafne Ruggiero, Stefania Terracciano, Carmen Festa, Alessandra Tosco, Maria Giovanna Chini, Gianluigi Lauro, Giuseppe Bifulco, Agostino Casapullo
Publikováno v:
Marine Drugs, Vol 22, Iss 1, p 41 (2024)
Mass spectrometry-based chemical proteomic approaches using limited proteolysis have become a powerful tool for the identification and analysis of the interactions between a small molecule (SM) and its protein target(s). Gracilioether A (GeA) is a po
Externí odkaz:
https://doaj.org/article/61b8b47449014fefab2662b62b23e431
Autor:
Erica Gazzillo, Stefania Terracciano, Dafne Ruggiero, Marianna Potenza, Maria Giovanna Chini, Gianluigi Lauro, Katrin Fischer, Robert Klaus Hofstetter, Assunta Giordano, Oliver Werz, Ines Bruno, Giuseppe Bifulco
Publikováno v:
Molecules, Vol 27, Iss 12, p 3866 (2022)
The development of new bioactive compounds represents one of the main purposes of the drug discovery process. Various tools can be employed to identify new drug candidates against pharmacologically relevant biological targets, and the search for new
Externí odkaz:
https://doaj.org/article/968f9ee74c334cf49eabf861eeb7485d
Autor:
Simone Di Micco, Stefania Terracciano, Dafne Ruggiero, Marianna Potenza, Maria C. Vaccaro, Katrin Fischer, Oliver Werz, Ines Bruno, Giuseppe Bifulco
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
We report the implementation of our in silico/synthesis pipeline by targeting the glutathione-dependent enzyme mPGES-1, a valuable macromolecular target in both cancer therapy and inflammation therapy. Specifically, by using a virtual fragment screen
Externí odkaz:
https://doaj.org/article/71095209381047b3a5acfad96c27ae5e
Autor:
Dafne Ruggiero, Stefania Terracciano, Gianluigi Lauro, Michela Pecoraro, Silvia Franceschelli, Giuseppe Bifulco, Ines Bruno
Publikováno v:
Molecules, Vol 27, Iss 3, p 665 (2022)
The multidomain BAG3 protein is a member of the BAG (Bcl-2-associated athanogene) family of co-chaperones, involved in a wide range of protein–protein interactions crucial for many key cellular pathways, including autophagy, cytoskeletal dynamics,
Externí odkaz:
https://doaj.org/article/90866a69328243cd812d607ba3ef888c
Autor:
Ester Colarusso, Sara Ceccacci, Maria Chiara Monti, Erica Gazzillo, Assunta Giordano, Maria Giovanna Chini, Maria Grazia Ferraro, Marialuisa Piccolo, Dafne Ruggiero, Carlo Irace, Stefania Terracciano, Ines Bruno, Giuseppe Bifulco, Gianluigi Lauro
Targeting bromodomain-containing protein 9 (BRD9) represents a promising strategy for the development of new agents endowed with anticancer properties. With this aim, a set of 2,4,5-trisubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one-based compounds wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b262d7a006b1739ffe998ec105fe5174
https://hdl.handle.net/11386/4826617
https://hdl.handle.net/11386/4826617
Autor:
Simona Pace, Vincenza Cantone, Dafne Ruggiero, Katrin Fischer, Stefania Terracciano, Oliver Werz, Giuseppe Bifulco, Ines Bruno, Gianluigi Lauro
Publikováno v:
ChemMedChem. 15:481-489
Dual inhibition of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO), two key enzymes involved in pro-inflammatory eicosanoid biosynthesis, represents a new strategy for treating inflammatory disorders. Herein we report the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0220c5ef883ec1e0bf0dbefab5c052ff
https://doi.org/10.1002/cmdc.201900694
https://doi.org/10.1002/cmdc.201900694
Autor:
Dafne Ruggiero, Stefania Terracciano, Gianluigi Lauro, Michela Pecoraro, Silvia Franceschelli, Giuseppe Bifulco, Ines Bruno
Publikováno v:
Molecules; Volume 27; Issue 3; Pages: 665
Molecules, Vol 27, Iss 665, p 665 (2022)
Molecules, Vol 27, Iss 665, p 665 (2022)
The multidomain BAG3 protein is a member of the BAG (Bcl-2-associated athanogene) family of co-chaperones, involved in a wide range of protein–protein interactions crucial for many key cellular pathways, including autophagy, cytoskeletal dynamics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3212f833fe7fc0839aeb10d8939f78c
https://pubmed.ncbi.nlm.nih.gov/35163936
https://pubmed.ncbi.nlm.nih.gov/35163936
Autor:
Oliver Werz, Maria C. Vaccaro, Ines Bruno, Katrin Fischer, Giuseppe Bifulco, Dafne Ruggiero, Marianna Potenza, Stefania Terracciano, Simone Di Micco
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Vol 9 (2021)
Frontiers in Chemistry, Vol 9 (2021)
We report the implementation of our in silico/synthesis pipeline by targeting the glutathione-dependent enzyme mPGES-1, a valuable macromolecular target in both cancer therapy and inflammation therapy. Specifically, by using a virtual fragment screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c750218a454c30ebd411393288e8c433
https://pubmed.ncbi.nlm.nih.gov/34046398
https://pubmed.ncbi.nlm.nih.gov/34046398
Autor:
Gianluigi Lauro, Raffaele Riccio, Stefania Terracciano, Dafne Ruggiero, Simona De Vita, Giuseppe Bifulco
Structure-based virtual screening is highly used in the early stages of drug discovery to identify new putative lead compounds for a given target. However, when a small molecule elicits a biological effect, but its target is unknown, or the side effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfad47fc8c552f6d9b8422b39a25304
http://hdl.handle.net/11386/4731290
http://hdl.handle.net/11386/4731290
Autor:
Stefania Terracciano, Faezeh Nemati, Maryam Mohebbi, Gianluigi Lauro, Peyman Salehi, Morteza Bararjanian, Dafne Ruggiero, Nasim Hadian, Giuseppe Bifulco, Ines Bruno
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127489
Twenty novel 1,2,3-triazole noscapine derivatives were synthesized starting from noscapine by consecutive N-demethylation, reduction of lactone ring, N-propargylation and Huisgen 1,3-dipolar cycloaddition reaction. In order to select the most promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51253d1a4728820083156a085fe0402
https://doi.org/10.1016/j.bmcl.2020.127489
https://doi.org/10.1016/j.bmcl.2020.127489