Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Dafna Greitzer-Antes"'
Autor:
Tao Liang, Dan Zhu, Herbert Y. Gaisano, Dafna Greitzer-Antes, Subhankar Dolai, Youhou Kang, Tairan Qin, Yan He, Li Xie, Alexandre B. Hardy, Fei Kang, Huanli Xie
Publikováno v:
Journal of Biological Chemistry. 293:6893-6904
The voltage-dependent K+ (Kv) channel Kv2.1 is a major delayed rectifier in many secretory cells, including pancreatic β cells. In addition, Kv2.1 has a direct role in exocytosis at an undefined step, involving SNARE proteins, that is independent of
Autor:
Dafna Greitzer-Antes, Anton Sheinin, Dafna Singer-Lahat, Izhak Michaelevski, Ilana Lotan, Noa Barak-Broner
Publikováno v:
The Journal of Neuroscience. 38:220-231
The exact function of the polybasic juxtamembrane region (5RK) of the plasma membrane neuronal SNARE, syntaxin 1A (Syx), in vesicle exocytosis, although widely studied, is currently not clear. Here, we addressed the role of 5RK in Ca2+-triggered rele
Autor:
Dafna Greitzer-Antes, John Maringa Githaka, Mette V. Jensen, Nicolas Touret, Gregory Plummer, Xiao-Qing Dai, Christopher B. Newgard, Jocelyn E. Manning Fox, Patrick E. MacDonald, Laura Senior, Herbert Y. Gaisano, Austin Bautista, Jianyang Fu, Kunimasa Suzuki
Publikováno v:
Diabetes
Insulin exocytosis is regulated by ion channels that control excitability and Ca2+ influx. Channels also play an increasingly appreciated role in microdomain structure. In this study, we examine the mechanism by which the voltage-dependent K+ (Kv) ch
Autor:
Gregory Plummer, Jianyang Fu, John Maringa Githaka, Ryekjang Kim, Jocelyn E. Manning Fox, Kunimasa Suzuki, Patrick E. MacDonald, Xiao-Qing Dai, Austin Bautista, Aliya F. Spigelman, Dafna Greitzer-Antes, Herbert Y. Gaisano
SUMMARYImpaired insulin secretion in type 2 diabetes (T2D) is linked to reduced insulin granule docking, disorganization of the exocytotic site, and an impaired glucose-dependent facilitation of insulin exocytosis. We show in β-cells from 80 human d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90773b1b33b963691a3819678313ffeb
https://europepmc.org/articles/PMC6629118/
https://europepmc.org/articles/PMC6629118/
Autor:
Robert K. Baker, Youhou Kang, Dan Zhu, Claes-Göran Östenson, Herbert Y. Gaisano, Fei Kang, Subhankar Dolai, Timothy J. Kieffer, Daorong Feng, Jeffrey E. Pessin, Li Xie, Tairan Qin, Kate Banks, Dafna Greitzer-Antes, Eva Tudurí, Tao Liang
Publikováno v:
JCI insight. 5(3)
SNAP23 is the ubiquitous SNAP25 isoform that mediates secretion in non-neuronal cells, similar to SNAP25 in neurons. However, some secretory cells like pancreatic islet β cells contain an abundance of both SNAP25 and SNAP23, where SNAP23 is believed
Autor:
Dafna, Greitzer-Antes, Li, Xie, Tairan, Qin, Huanli, Xie, Dan, Zhu, Subhankar, Dolai, Tao, Liang, Fei, Kang, Alexandre B, Hardy, Yan, He, Youhou, Kang, Herbert Y, Gaisano
Publikováno v:
The Journal of biological chemistry. 293(18)
The voltage-dependent K(+) (K(v)) channel K(v)2.1 is a major delayed rectifier in many secretory cells, including pancreatic β cells. In addition, K(v)2.1 has a direct role in exocytosis at an undefined step, involving SNARE proteins, that is indepe
Autor:
Dafna, Singer-Lahat, Noa, Barak-Broner, Anton, Sheinin, Dafna, Greitzer-Antes, Izhak, Michaelevski, Ilana, Lotan
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(1)
The exact function of the polybasic juxtamembrane region (5RK) of the plasma membrane neuronal SNARE, syntaxin 1A (Syx), in vesicle exocytosis, although widely studied, is currently not clear. Here, we addressed the role of 5RK in Ca(2+)-triggered re
Autor:
Jocelyn E. Manning Fox, Kunimasa Suzuki, Herbert Y. Gaisano, Jianyang Fu, Mette V. Jensen, Christopher B. Newgard, Patrick E. MacDonald, Xiao-Qing Dai, Gregory Plummer, Dafna Greitzer-Antes
Publikováno v:
Canadian Journal of Diabetes. 41:S11-S12
Autor:
Dafna Greitzer-Antes, Roi Strulovich, Adi Etzioni, Joel A. Hirsch, Sivan Siloni, Dodo Chikvashvilli, Dana Sachyani, Noa Regev, Ilana Lotan
Publikováno v:
The Journal of Neuroscience. 31:14158-14171
Whereas neuronal M-type K+channels composed of KCNQ2 and KCNQ3 subunits regulate firing properties of neurons, presynaptic KCNQ2 subunits were demonstrated to regulate neurotransmitter release by directly influencing presynaptic function. Two interac
Pancreatitis-Induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis
Autor:
Tanveer A. Javed, Tao Liang, Patrick P.L. Lam, Douglas Holmyard, Subhankar Dolai, Peter Thorn, Youhou Kang, Herbert Y. Gaisano, Dafna Greitzer-Antes, Li Xie, Deborah C. Rubin, Huanli Xie, Abrahim I. Orabi
Publikováno v:
Gastroenterology. 154:1805-1821.e5
BACKGROUND & AIMS: Pancreatic acinar cells are polarized epithelial cells that store enzymes required for digestion as inactive zymogens, tightly packed at the cell apex. Stimulation of acinar cells causes the zymogen granules to fuse with the apical