Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dafna, Amir"'
Autor:
Ishay Columbus, Lee Ghindes-Azaria, Ravit Chen, Lea Yehezkel, Orit Redy-Keisar, Gil Fridkin, Dafna Amir, Daniele Marciano, Eyal Drug, Eytan Gershonov, Ziv Klausner, Sigal Saphier, Shlomi Elias, Alexander Pevzner, Yoav Eichen, Galit Parvari, Boris Smolkin, Yossi Zafrani
Publikováno v:
Journal of Medicinal Chemistry. 65:8511-8524
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a544e2af5c2a46109cd26b13e235cddd
https://doi.org/10.1021/acs.jmedchem.2c00658
https://doi.org/10.1021/acs.jmedchem.2c00658
Autor:
Ishay, Columbus, Lee, Ghindes-Azaria, Ravit, Chen, Lea, Yehezkel, Orit, Redy-Keisar, Gil, Fridkin, Dafna, Amir, Daniele, Marciano, Eyal, Drug, Eytan, Gershonov, Ziv, Klausner, Sigal, Saphier, Shlomi, Elias, Alexander, Pevzner, Yoav, Eichen, Galit, Parvari, Boris, Smolkin, Yossi, Zafrani
Publikováno v:
Journal of medicinal chemistry. 65(12)
Systematically studying the lipophilicity of phosphorus compounds is of great importance for many chemical and biological fields and particularly for medicinal chemistry. Here, we report on the study of trends in the lipophilicity of a wide set of ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f649c78c964b18c7120450dee64fedbc
https://pubmed.ncbi.nlm.nih.gov/35678759
https://pubmed.ncbi.nlm.nih.gov/35678759
Publikováno v:
Synthesis. 51:4549-4567
Recent years have witnessed a growing interest in the development of novel synthetic methods and new reagents for the synthesis of difluoromethylated compounds. Dozens of studies have been published on this topic each year over the past few years. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca854afaa9e2ce0d9f23d00f4e8ff59
https://doi.org/10.1055/s-0039-1690027
https://doi.org/10.1055/s-0039-1690027
Autor:
Daniele Marciano, Yossi Zafrani, Dafna Amir, Gali Sod-Moriah, Nissan Ashkenazi, Shlomi Elias, Moran Madmon, Dina Yeffet, Eytan Gershonov, Anat Berliner, Shahaf Katalan, Sigal Saphier
Publikováno v:
Journal of Medicinal Chemistry. 62:5628-5637
The effects of the CF2H moiety on H-bond acidity and lipophilicity of various compounds, when attached directly to an aromatic ring or to other functions like alkyls, ethers/thioethers or electron withdrawing groups, are discussed. It was found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ff9dbfdccf5cf2d24cc845efd8c8e21
https://doi.org/10.1021/acs.jmedchem.9b00604
https://doi.org/10.1021/acs.jmedchem.9b00604
Autor:
Shahaf Katalan, Eytan Gershonov, Yossi Zafrani, Yoav Eichen, Galit Parvari, Lee Ghindes-Azaria, Shlomi Elias, Sigal Saphier, Anat Berliner, Alexander Pevzner, Gil Fridkin, Dafna Amir
Publikováno v:
Journal of medicinal chemistry. 64(8)
Modulation of the H-bond basicity (pKHB) of various functional groups (FGs) by attaching fluorine functions and its impact on lipophilicity and bioisosterism considerations are described. In general, H/F replacement at the α-position to H-bond accep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a5bb2e33830fe51850db0c904c2617
https://pubmed.ncbi.nlm.nih.gov/33844540
https://pubmed.ncbi.nlm.nih.gov/33844540
Autor:
Lea Yehezkel, Yossi Zafrani, Daniele Marciano, Gil Fridkin, Orit Redy-Keisar, Iris Binyamin, Eytan Gershonov, Eyal Drug, Dafna Amir
Publikováno v:
Journal of Fluorine Chemistry. 250:109867
The effective difluoromethylations of various S- and O- based- nucleophiles, presenting a wide range of pKa values, using diethyl(bromodifluoromethyl) phosphonate (1) under basic conditions is described. These reactions, which rely on the quantitativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85df558034b04b2af36efc9e47fd491b
https://doi.org/10.1016/j.jfluchem.2021.109867
https://doi.org/10.1016/j.jfluchem.2021.109867
Autor:
Yossi, Zafrani, Gali, Sod-Moriah, Dina, Yeffet, Anat, Berliner, Dafna, Amir, Daniele, Marciano, Shlomi, Elias, Shahaf, Katalan, Nissan, Ashkenazi, Moran, Madmon, Eytan, Gershonov, Sigal, Saphier
Publikováno v:
Journal of medicinal chemistry. 62(11)
The effects of the CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67db1d908228a308ae25e5b656c2b809
https://pubmed.ncbi.nlm.nih.gov/31091098
https://pubmed.ncbi.nlm.nih.gov/31091098
Autor:
Gali Sod-Moriah, Yossi Zafrani, Eytan Gershonov, Sigal Saphier, Anat Berliner, Dina Yeffet, Daniele Marciano, Dafna Amir
Publikováno v:
Journal of medicinal chemistry. 60(2)
There is a growing interest in organic compounds containing the difluoromethyl group, as it is considered a lipophilic hydrogen bond donor that may act as a bioisostere of hydroxyl, thiol, or amine groups. A series of difluoromethyl anisoles and thio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17f485d8b60f56797d4ea948a79a617
https://pubmed.ncbi.nlm.nih.gov/28051859
https://pubmed.ncbi.nlm.nih.gov/28051859
Autor:
Moran Madmon, Yossi Zafrani, Eytan Gershonov, Lea Yehezkel, Sigal Saphier, Naama Karton-Lifshin, Dafna Amir
Publikováno v:
The Journal of organic chemistry. 81(19)
A practical, convenient, and general method for the difluoromethylation of tertiary amines, using diethyl bromodifluoromethylphosphonate and fluoride, is described. This commercially available phosphonate smoothly reacts with a fluoride ion to libera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fefb2b638e9bc7caaa39c764c60a64
https://pubmed.ncbi.nlm.nih.gov/27607245
https://pubmed.ncbi.nlm.nih.gov/27607245