Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Daesong Jang"'
Autor:
Daesong Jang, Marvin C. Gershengorn, Sarah J. Morgan, Susanne Neumann, Joanna Klubo-Gwiezdzinska, J. Paul Banga
Publikováno v:
Thyroid
Background: Thyrotropin (TSH) and thyroid-stimulating antibodies (TSAbs) activate TSH receptor (TSHR) signaling by binding to its extracellular domain. TSHR signaling has been studied extensively in animal thyrocytes and in engineered cell lines, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0871c0744647e6e2010d5d3548a5c3b
https://doi.org/10.1089/thy.2019.0418
https://doi.org/10.1089/thy.2019.0418
Autor:
Daesong Jang, Elena Eliseeva, Joanna Klubo-Gwiezdzinska, Susanne Neumann, Marvin C. Gershengorn
Publikováno v:
Cell Signal
The TSH receptor (TSHR) is the major regulator of thyroid hormone biosynthesis in human thyrocytes by regulating the transcription of a number of genes including thyroglobulin (TG) and thyroperoxidase (TPO). Until recently, it was thought that TSHR i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ab46bd06074eb0b07a455c5aed7f24
https://pubmed.ncbi.nlm.nih.gov/34896620
https://pubmed.ncbi.nlm.nih.gov/34896620
Autor:
Joanna Klubo-Gwiezdzinska, Christine C Krieger, Bernice Marcus-Samuels, Susanne Neumann, Sarah S. Malik, Marvin C. Gershengorn, Elena Eliseeva, Daesong Jang
Publikováno v:
Molecular Pharmacology. 97:2-8
The thyrotropin (TSH) receptor (TSHR) signals via G proteins of all four classes and β-arrestin 1. Stimulation of TSHR leads to increasing cAMP production that has been reported as a monotonic dose-response curve that plateaus at high TSH doses. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed06ea0ce8f38e2db5972cddbe99a1ec
https://doi.org/10.1124/mol.119.117382
https://doi.org/10.1124/mol.119.117382
Autor:
Susanne, Neumann, Sarah S, Malik, Bernice, Marcus-Samuels, Elena, Eliseeva, Daesong, Jang, Joanna, Klubo-Gwiezdzinska, Christine C, Krieger, Marvin C, Gershengorn
Publikováno v:
Molecular pharmacology. 97(1)
The thyrotropin (TSH) receptor (TSHR) signals via G proteins of all four classes and β-arrestin 1. Stimulation of TSHR leads to increasing cAMP production that has been reported as a monotonic dose-response curve that plateaus at high TSH doses. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3138d4470970cedd2340a51d85fe7e52
https://pubmed.ncbi.nlm.nih.gov/31704717
https://pubmed.ncbi.nlm.nih.gov/31704717
Autor:
Alisa Boutin, J. Paul Banga, George J. Kahaly, Sarah J. Morgan, Daesong Jang, Christine C Krieger, Susanne Neumann, Joanna Klubo-Gwiezdzinska, Marvin C. Gershengorn
Endogenously expressed TSH receptors (TSHRs) on orbital fibroblasts of patients with Graves ophthalmopathy (GO) use crosstalk with IGF1 receptors (IGF1R) to synergistically stimulate secretion of hyaluronan (HA), a major component of GO pathology. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741876242a0576d34885567bcef026dd
https://europepmc.org/articles/PMC6542485/
https://europepmc.org/articles/PMC6542485/
Autor:
Susanne Neumann, Bernice Marcus-Samuels, Joanna Klubo-Gwiezdzinska, Sarah J. Morgan, Daesong Jang, Marvin C. Gershengorn
Publikováno v:
Mol Cell Endocrinol
Thyroid transcription factors (TTFs) - NKX2-1, FOXE1, PAX8 and HHEX - regulate multiple genes involved in thyroid development in mice but little is known about TTF regulation of thyroid-specific genes - thyroglobulin (TG), thyroid peroxidase (TPO), d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf82385c92a74d82d3bbb67914d826b
https://doi.org/10.1016/j.mce.2020.111032
https://doi.org/10.1016/j.mce.2020.111032