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FRTX-02, a selective and potent inhibitor of DYRK1A, modulates inflammatory pathways in mouse models of psoriasis and atopic dermatitis

Autor: Soochan Kim, Eunhwa Ko, Hwan Geun Choi, Daekwon Kim, Monica Luchi, Bernard Khor, Sunghwan Kim

Publikováno v: Journal of Translational Autoimmunity, Vol 6, Iss , Pp 100185- (2023)

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) has been proposed as a novel regulator of adaptive immune homeostasis through modulating T cell polarization. Thus, DYRK1A could present a potential target in autoimmune disorder

Externí odkaz: https://doaj.org/article/37e1bd99114844d1b6ad44b987dd352f

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Abstract LB521: Antitumor activity of potent RAF inhibitors in solid tumors with activated RAS-RAF axis

Autor: Kwangwoo Hwang, SeoHyun Jo, Jieun Choi, Ga-young Choi, Jiseon Choi, Ji-Hye Kwon, Dong-Guk Shin, Jiyeon Kim, Se-Hyuk Kim, Haelee Kim, Ha Yeon Cho, Jung Beom Son, Nam Doo Kim, Hwan Geun Choi, Daekwon Kim, Sunghwan Kim

Publikováno v: Cancer Research. 82:LB521-LB521

FDA approved three RAF inhibitors for the treatment of tumors containing BRAFV600 mutations, but one of the major drawbacks of these type I RAF inhibitors is to activate MAPK signaling pathway, instead of inhibiting signaling, which is referred to as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eed613962e35bc81098d392570afd873
https://doi.org/10.1158/1538-7445.am2022-lb521

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Abstract LB139: VRN10, Discovery of Potent Irreversible HER2 Kinase Inhibitors with Intracranial Activity

Autor: Somi Lee, Eunhwa Ko, Nam Doo Kim, Sunghwan Kim, Hwan Geun Choi, Kim Hwan, Ji Eun Choi, Younho Lee, Chanmi Park, Jihye Yoo, Son Jung Beom, Daekwon Kim, Park Jin-Hee, Youngyi Lee

Publikováno v: Cancer Research. 81:LB139-LB139

Human epidermal growth factor receptor 2 (HER2) amplification is one of oncogenic drivers most found in breast cancer but also occurs in multiple other tumor types. Approximately 10-30% of patients with breast cancer develop brain metastases (BCBM),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b365ccbefb06004be8e8ee65e5554603
https://doi.org/10.1158/1538-7445.am2021-lb139

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Abstract LB119: VRN08, a Selective Mps1 Kinase Inhibitor Induces Mitotic Catastrophe and Apoptosis Efficiently in Advanced Cancers Including Rb1-Deficient

Autor: Yeon-Sil Kim, Nam Doo Kim, Dong-hyuk Seo, Ji-Hye Kwon, Haelee Kim, Jung Hong Ryul, Sunghwan Kim, Son Jung Beom, Daekwon Kim

Publikováno v: Cancer Research. 81:LB119-LB119

Spindle assembly checkpoint (SAC) prevents mis-segregation of chromosome and allows accurate division in mitosis. Mps1 (also known as TTK) is one of the essential kinases for recruitment of SAC proteins after chromosome segregation. Failure of SAC in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ef3fdf2a369e5f414fc8cfbd9f771ee
https://doi.org/10.1158/1538-7445.am2021-lb119

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