Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daehyeon Seong"'
Autor:
Yeaji Kim, Dong Young Kim, Haiying Zhang, Cho-Rong Bae, Daehyeon Seong, Yeomyung Kim, Jaewhan Song, Young-Myeong Kim, Young-Guen Kwon
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background In sprouting angiogenesis, VEGFR2 level is regulated via a fine-tuned process involving various signaling pathways. Other than VEGF/VEGFR2 signaling pathway, Wnt/ β-catenin signaling is also important in vascular development. How
Externí odkaz:
https://doaj.org/article/e1644512cab04655ab92d3a67dfdc93c
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3)
Externí odkaz:
https://doaj.org/article/5ee8c3c1d0c74fad8221aab47d481fd8
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1143 (2020)
Tumorigenesis can be induced by various stresses that cause aberrant DNA mutations and unhindered cell proliferation. Under such conditions, normal cells autonomously induce defense mechanisms, thereby stimulating tumor suppressor activation. ARF, en
Externí odkaz:
https://doaj.org/article/9d7eb6b8731645c0a822b6bea798b419
Autor:
Sang Jun Ha, Eun-Woo Lee, Seung Jun Kim, Manhyung Jeong, Jeong Yoon Shin, Jin-Ho Seo, Andrew Oberst, Ho-Chul Shin, Jeong Yeon Jo, Chi Hyun Hwang, Hwa Ryeon Kim, June-Won Cheong, Kwang-Hee Bae, Haeseung Lee, Wankyu Kim, Donghoon Shin, Ji Yoon Lee, Peter Vandenabeele, Daehyeon Seong, Hye Jung Kim, Young Woo Nam, Ji Hoon Oh, Jae Seok Roe, Jaewhan Song, Sang Chul Lee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Significance A major yet perplexing question in the field of necroptosis is the role and involvement of necroptosis in cancer cells. Many cancer cells have protective mechanisms against necroptosis, but the underlying mechanism remains elusive. We re
Autor:
Seung Ri Lee, Jaewhan Song, Young Jin, Jin-Ho Seo, Peter Vandenabeele, Young Woo Nam, Han Woong Lee, Choong Sil Lee, Doo Byoung Oh, Daehyeon Seong, Chi Hyun Hwang
Publikováno v:
Cell Death and Differentiation
CELL DEATH AND DIFFERENTIATION
CELL DEATH AND DIFFERENTIATION
Necroptosis is a form of regulated cell death caused by formation of the necrosome complex. However, the factors modulating this process and the systemic pathophysiological effects of necroptosis are yet to be understood. Here, we identified that Bec
Autor:
Jihye Shin, Young Woo Nam, Jin-Ho Seo, Eun-Woo Lee, Manhyung Jeong, Seon Hyeong Lee, Daehyeon Seong, Jaewhan Song, Cheolju Lee
Publikováno v:
Oncogene. 37:4994-5006
Fas-associated death domain (FADD) is an adaptor protein recruiting complexes of caspase 8 to death ligand receptors to induce extrinsic apoptotic cell death in response to a TNF superfamily member. Although, formation of the complex of FADD and casp
Publikováno v:
Archives of pharmacal research. 42(1)
C-terminus of heat shock protein 70 (HSP70)-interacting protein (CHIP) is an E3 ligase involved in a variety of protein homeostasis events implicated in diverse signaling pathways. Its involvement in varied and even opposite signaling circuits might
Autor:
Jin-Ho Seo, Sasker Grootjans, E-W Lee, S-Y Kim, Jaewhan Song, J-H Kim, Peter Vandenabeele, Daehyeon Seong, Moonsup Jeong
Publikováno v:
Oncogene. 36:458-470
FLICE-like inhibitory protein (FLIP) is a critical regulator of death receptor-mediated apoptosis. Here, we found ubiquitin-specific peptidase 8 (USP8) to be a novel deubiquitylase of the long isoform of FLIP (FLIPL). USP8 directly deubiquitylates an
Publikováno v:
Biomolecules
Biomolecules, Vol 10, Iss 1143, p 1143 (2020)
Biomolecules, Vol 10, Iss 1143, p 1143 (2020)
Tumorigenesis can be induced by various stresses that cause aberrant DNA mutations and unhindered cell proliferation. Under such conditions, normal cells autonomously induce defense mechanisms, thereby stimulating tumor suppressor activation. ARF, en
Publikováno v:
Cell Death & Differentiation. 22:1463-1476
Given their crucial role in apoptosis suppression, inhibitor of apoptosis proteins (IAPs) have recently become attractive targets for cancer therapy. Here, we report that cellular IAP2 (cIAP2) is specifically stabilized in several cancer cell lines,