Threonyl-tRNA Synthetase Promotes T Helper Type 1 Cell Responses by Inducing Dendritic Cell Maturation and IL-12 Production via an NF-κB Pathway

Autor: Hak-Jun Jung, Su-Ho Park, Kyung-Min Cho, Kwang Il Jung, Daeho Cho, Tae Sung Kim

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Threonyl-tRNA synthetase (TRS) is an aminoacyl-tRNA synthetase that catalyzes the aminoacylation of tRNA by transferring threonine. In addition to an essential role in translation, TRS was extracellularly detected in autoimmune diseases and also exhi

Externí odkaz: https://doaj.org/article/621f794535b74d249b19238c76284118

Vibrio vulnificus RtxA Is a Major Factor Driving Inflammatory T Helper Type 17 Cell Responses in vitro and in vivo

Autor: Arim Lee, Myun Soo Kim, Daeho Cho, Kyung Ku Jang, Sang Ho Choi, Tae Sung Kim

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

T helper type 17 (Th17) cells are a subset of pro-inflammatory T helper cells that mediate host defense and pathological inflammation. We have previously reported that host dendritic cells (DCs) infected with Vibrio vulnificus induce Th17 responses t

Externí odkaz: https://doaj.org/article/e35d1fe9a6f140a89e73605bc09d1b88

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 induces microglial activation and M1 polarization via the MAPK-NF-κB signaling pathway

Autor: Yebin Oh, Hak-Jun Jung, Seungwon Hong, Yerim Cho, Daeho Cho, Tae Sung Kim

BackgroundActivation of microglia, which are the primary immune cell of the central nervous system, plays an important role in neuroinflammation associated with several neuronal diseases. Aminoacyl tRNA synthetase (ARS) complex-interacting multifunct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288123d76a0fd8bab2f145222d4fc160
https://doi.org/10.21203/rs.3.rs-1475701/v2

Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway

Autor: Myun Soo Kim, Dongmin Park, Sora Lee, Sunyoung Park, Kyung Eun Kim, Tae Sung Kim, Hyun Jeong Park, Daeho Cho

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 844, p 844 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 844
International Journal of Molecular Sciences

Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491fc954836c5c27b0c34ee557634fd1
https://www.mdpi.com/1422-0067/23/2/844

Novel Application of Radotinib for the Treatment of Solid Tumors via Natural Killer Cell Activation

Autor: Jeongmin Park, Dong Yeon Kim, Daeho Cho, Dae Jin Cho, Kyung Eun Kim, Hyun Jeong Park, Sunyoung Park, Dae Young Hur, Soyoung Cheon

Publikováno v: Journal of Immunology Research

Radotinib (Supect™) was developed to treat chronic myeloid leukemia (CML) as a BCR-ABL1 tyrosine kinase inhibitor (TKI). Other TKIs, including imatinib and nilotinib, were also developed for treatment of CML, and recent studies were increasing abou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b9757d7dc18358526e192e60ee9bf3
https://doi.org/10.1155/2018/9580561