Targeted Transposition of Minicircle DNA Using Single-Chain Antibody Conjugated Cyclodextrin-Modified Poly (Propylene Imine) Nanocarriers

Autor: Jugel, Willi, Tietze, Stefanie, Daeg, Jennifer, Appelhans, Dietmar, Broghammer, Felix, Aigner, Achim, Karimov, Michael, Schackert, Gabriele, Temme, Achim

Among non-viral vectors, cationic polymers, such as poly(propylene imine) (PPI), play a prominent role in nucleic acid delivery. However, limitations of polycationic polymer-based DNA delivery systems are (i) insufficient target specificity, (ii) uns

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Targeted Transposition of Minicircle DNA Using Single-Chain Antibody Conjugated Cyclodextrin-Modified Poly (Propylene Imine) Nanocarriers.

Autor: Jugel W; Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany., Tietze S; Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany., Daeg J; Leibniz Institute of Polymer Research Dresden e.V., Mailbox 120411, 01069 Dresden, Germany., Appelhans D; Leibniz Institute of Polymer Research Dresden e.V., Mailbox 120411, 01069 Dresden, Germany., Broghammer F; Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany., Aigner A; Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Faculty of Medicine, University of Leipzig, 04107 Leipzig, Germany., Karimov M; Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Faculty of Medicine, University of Leipzig, 04107 Leipzig, Germany., Schackert G; Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, 01307 Dresden, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; National Center for Tumor Diseases (NCT), 01307 Dresden, Germany., Temme A; Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, 01307 Dresden, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; National Center for Tumor Diseases (NCT), 01307 Dresden, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2022 Apr 11; Vol. 14 (8). Date of Electronic Publication: 2022 Apr 11.