Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Dae-sik Lim"'
Autor:
Daehee Hwang, Seonguk Baek, Jeeyoon Chang, Taejun Seol, Bomin Ku, Hongseok Ha, Hyeonji Lee, Suhyeon Cho, Tae-Young Roh, Yoon Ki Kim, Dae-Sik Lim
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 10, Pp 2202-2215 (2024)
Abstract Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) play fundamental roles in stem/progenitor cell expansion during homeostasis, and their dysregulation often leads to tissue overgrowth. Here, we show t
Externí odkaz:
https://doaj.org/article/f04ea68be050476687d95f43b243e34e
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103354- (2024)
Summary: Evaluating the synergy of drug combinations is crucial in advancing treatment regimens. Here, we present a protocol to establish primary cells and organoids from murine tumors and calculate drug synergy. We describe all necessary cell cultur
Externí odkaz:
https://doaj.org/article/a3622ad9c92a4234a592a0cf2d5808ff
Formation of a giant unilocular vacuole via macropinocytosis-like process confers anoikis resistance
Publikováno v:
eLife, Vol 13 (2024)
Cell survival in metazoans depends on cell attachment to the extracellular matrix (ECM) or to neighboring cells. Loss of such attachment triggers a type of programmed cell death known as anoikis, the acquisition of resistance to which is a key step i
Externí odkaz:
https://doaj.org/article/41779fc047b94ee98d7a83c8b1f233be
Autor:
Dae Jin Jeong, Jee-Hyun Um, Young Yeon Kim, Dong Jin Shin, Sangwoo Im, Kang-Min Lee, Yun-Hee Lee, Dae-sik Lim, Donghoon Kim, Jeanho Yun
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 3, Pp 674-685 (2024)
Abstract Mitophagy induction upon mitochondrial stress is critical for maintaining mitochondrial homeostasis and cellular function. Here, we found that Mst1/2 (Stk3/4), key regulators of the Hippo pathway, are required for the induction of mitophagy
Externí odkaz:
https://doaj.org/article/5289986abeed4912a59d96604e4b6aab
Autor:
Anna Park, Kwang-eun Kim, Isaac Park, Sang Heon Lee, Kun-Young Park, Minkyo Jung, Xiaoxu Li, Maroun Bou Sleiman, Su Jeong Lee, Dae-Soo Kim, Jaehoon Kim, Dae-Sik Lim, Eui-Jeon Woo, Eun Woo Lee, Baek Soo Han, Kyoung-Jin Oh, Sang Chul Lee, Johan Auwerx, Ji Young Mun, Hyun-Woo Rhee, Won Kon Kim, Kwang-Hee Bae, Jae Myoung Suh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Mitochondrial uncoupling protein 1 (UCP1) is activated in BAT during cold stress and dissipates mitochondrial proto
Externí odkaz:
https://doaj.org/article/8abfab449c994b11bb6233d6bda9aba7
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The release of neutrophils from the bone marrow into the blood circulation is essential for neutrophil homeostasis and the protection of the organism from invading microorganisms. Granulocyte colony-stimulating factor (G-CSF) plays a pivotal role in
Externí odkaz:
https://doaj.org/article/dbfe815224024da49e6b308619ae5c92
Autor:
Ting Yuan, Karthika Annamalai, Shruti Naik, Blaz Lupse, Shirin Geravandi, Anasua Pal, Aleksandra Dobrowolski, Jaee Ghawali, Marina Ruhlandt, Kanaka Durga Devi Gorrepati, Zahra Azizi, Dae-Sik Lim, Kathrin Maedler, Amin Ardestani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-c
Externí odkaz:
https://doaj.org/article/fff43c630ec94cdfb9d466891db5de81
Autor:
Sung Yong Choi, Hosung Bae, Sun-Hye Jeong, Intae Park, Hyunsoo Cho, Seon Pyo Hong, Da-Hye Lee, Choong-kun Lee, Jin-Sung Park, Sang Heon Suh, Jeongwoon Choi, Myung Jin Yang, Jeon Yeob Jang, Lucas Onder, Jeong Hwan Moon, Han-Sin Jeong, Ralf H. Adams, Jin-Man Kim, Burkhard Ludewig, Joo-Hye Song, Dae-Sik Lim, Gou Young Koh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Fibroblastic reticular cells (FRC) are important for lymph node (LN) structure and function. Here the authors show that the YAP/TAZ complex downstream of Hippo signalling regulates FRC commitment and maturation, with YAP/TAZ deficiency impairing FRC
Externí odkaz:
https://doaj.org/article/354526f25abf44f89bb47da409f5948a
Autor:
Fengyuan Tang, Ruize Gao, Beena Jeevan-Raj, Christof B. Wyss, Ravi K. R. Kalathur, Salvatore Piscuoglio, Charlotte K. Y. Ng, Sravanth K. Hindupur, Sandro Nuciforo, Eva Dazert, Thomas Bock, Shuang Song, David Buechel, Marco F. Morini, Alexander Hergovich, Patrick Matthias, Dae-Sik Lim, Luigi M. Terracciano, Markus H. Heim, Michael N. Hall, Gerhard Christofori
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sor
Externí odkaz:
https://doaj.org/article/1bd4d7c4bf134f42b2b569c6511ab4d1
Autor:
Yoo Hyung Kim, Jeongwoon Choi, Myung Jin Yang, Seon Pyo Hong, Choong-kun Lee, Yoshiaki Kubota, Dae-Sik Lim, Gou Young Koh
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Angiogenesis is driven by the directed migration of tip endothelial cells towards hypoxic tissues. Here, Kim et al. show that the generation of reactive oxygen species in endothelial cells upon hypoxia activates MST1, which subsequently promotes the
Externí odkaz:
https://doaj.org/article/ff05290b95594556b9afa965bdd2d71b