Výsledky vyhledávání - "Dae Yeun Hwang"

Memory Impairment in Estrogen Receptor α Knockout Mice Through Accumulation of Amyloid-β Peptides

Autor: Byung Kook Hyun, Ju Kyung Song, Sang-Bae Han, Dong Young Choi, Jin Tae Hong, Hyun Ok Seo, Ki-Wan Oh, Dae Yeun Hwang, Hwan-Soo Yoo, Chul Ju Hwang, Hyung-Mun Yun, Kyung-Ran Park

Publikováno v: Molecular Neurobiology

Estrogen has been known to reduce the development of Alzheimer’s disease (AD). However, exact mechanisms are not clear. We investigated whether estrogen can increase amyloid-beta (Aβ) degradation and affects Aβ-induced memory impairment in an est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25c96865bc068967c1dfaa419a55ba8
https://pubmed.ncbi.nlm.nih.gov/25128029

Zobrazit plný text záznamu

Mutant presenilin 2 increases β-secretase activity through reactive oxygen species-dependent activation of extracellular signal-regulated kinase

Autor: Sang-Bae Han, Dae Yeun Hwang, Hwan-Soo Yoo, Mi Hee Park, Jin Tae Hong, Jin-Yi Han, Hae Won Jin, Dong Young Choi, Ki-Wan Oh

Publikováno v: Journal of neuropathology and experimental neurology. 71(2)

Senile plaques composed of β-amyloid (Aβ) are a pathological hallmark of Alzheimer disease. Presenilin 2 (PS2) mutations increase Aβ generation in the brains of Alzheimer disease patients, but the underlying mechanism of Aβ generation by PS2 muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba12159cec9315e2f791763965bcd048
https://pubmed.ncbi.nlm.nih.gov/22249458

Zobrazit plný text záznamu