Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Dae Hong Shin"'
Publikováno v:
Archives of Pharmacal Research. 29:1061-1065
A new chiral derivatization agent with sugar moiety, 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl isothiocyanate (GATC) was synthesized. Several beta-blockers were investigated for the possible separation of the enantiomers by reversed-phase HPLC a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2723cf5b31cb8a405caf3d69653feedb
https://doi.org/10.1007/bf02969292
https://doi.org/10.1007/bf02969292
Autor:
Dae Hong Shin, Gilles Gosselin, Kenneth A. Jacobson, Christophe Mathé, Pedro Besada, Julien Gagneron, Savitri Maddileti, Stefano Costanzi, T. Kendall Harden, Hyojin Ko
Publikováno v:
Journal of Medicinal Chemistry. 49:5532-5543
The structure-activity relationships and molecular modeling of the uracil nucleotide activated P2Y6 receptor have been studied. Uridine 5'-diphosphate (UDP) analogues bearing substitutions of the ribose moiety, the uracil ring, and the diphosphate gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2239056072fb7b1034b8ab7c0558a6b4
https://doi.org/10.1021/jm060485n
https://doi.org/10.1021/jm060485n
Autor:
Srikar Rao, Jeong A. Lee, Dae Hong Shin, Sang Kook Lee, Hea Ok Kim, Moon Woo Chun, Heng T. Duong, Hyung Ryong Moon, Prashantha Gunaga, Ji Young Jung, Zhan-Guo Gao, Dong Zhe Jin, Kenneth A. Jacobson, Lak Shin Jeong, Hyuk Woo Lee
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:4718-4730
A large series of N6-substituted-4′-thioadenosines were synthesized starting from d -gulonic-γ-lactone, and structure–activity relationships were studied at the human A3 and other subtypes of adenosine receptors (ARs). 2-Chloro-substituted and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b12033bab88b5474ee6fdbcada1d9e
https://doi.org/10.1016/j.bmc.2006.03.030
https://doi.org/10.1016/j.bmc.2006.03.030
Autor:
Lak Shin Jeong, Sang Kook Lee, Hye-Young Min, Dae-Hong Shin, Eun-Jung Park, Hwa-Jin Chung, Eun-Jin Lee
Publikováno v:
Biochemical Pharmacology. 70:918-924
Human A3 adenosine receptor (A3AR) agonists have been shown to play important roles in several physiological and pathological processes, including growth inhibition of human cancer cells. On this line, we recently found that a novel adenosine analog,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299e9c579bfa2f27fa78623178d1be7a
https://doi.org/10.1016/j.bcp.2005.06.017
https://doi.org/10.1016/j.bcp.2005.06.017
Autor:
Hee-Doo Kim, Joong Hyup Kim, Lak Shin Jeong, Dae Hong Shin, Moon Woo Chun, Hea Ok Kim, Hyung Ryong Moon, Jae Gyu Park, Kang Man Lee, Won Jun Choi
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 22:589-592
Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f479b42788598f32bf0fd6e4ee738312
https://doi.org/10.1081/ncn-120021961
https://doi.org/10.1081/ncn-120021961
Publikováno v:
Archives of Pharmacal Research. 23:302-309
Based on (-)-neplanocin A with the 5'-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo- and arabino derivatives were synthesized from D-ribose using the Mitsunobu reaction as a key step. None of the final nucleosides di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd5557642e2a56ff3ba152457ef8ca0
https://doi.org/10.1007/bf02975438
https://doi.org/10.1007/bf02975438
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1475-1480
Novel 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents (1a–4b) were each synthesized with good yields through the condensation of dinucleophiles (oxygen and/or sulfur) with 1,3-dibenzoxy-2-propanon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::339d7d740c68b9cff21ca4366733ed59
https://doi.org/10.1016/s0960-894x(97)00250-3
https://doi.org/10.1016/s0960-894x(97)00250-3
Autor:
Hea Ok Kim, Kilhyoun Kim, Hye-Jin Kim, Lak Shin Jeong, Dae Hong Shin, Won Jun Choi, Mi Kyung Yun, Yhun Yhong Sheen, Kang Man Lee, Moon Woo Chun, Young Mi Ko, Jeong A. Lee, Hyung Ryong Moon
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 24:611-613
The preparative and stereoselective synthesis (45–50% overall yields, >50 g scale) of the key carbasugars 7a–d was achieved from D-ribose via stereoselective Grignard reaction and oxidative rearrangement as key reactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdab723ffef9aacd13b368b4490e3e73
https://doi.org/10.1081/ncn-200061832
https://doi.org/10.1081/ncn-200061832
Autor:
Hyouk Woo Lee1, Dae Hong Shin2, Ji Young Jeong2, Hea Ok Kim3, Moon Woo Chun1, Melman, N.3, Gao, Z.-G.3, Jacobson, Kenneth3, Lak Shin Jeong2
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. May2005, Vol. 24 Issue 5-7, p607-609. 3p. 2 Diagrams.
Publikováno v:
ChemInform. 28
Novel 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents (1a–4b) were each synthesized with good yields through the condensation of dinucleophiles (oxygen and/or sulfur) with 1,3-dibenzoxy-2-propanon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42798f9c2b5ceb6255cc0914c22998bb
https://doi.org/10.1002/chin.199742271
https://doi.org/10.1002/chin.199742271