The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults.

Autor: Nakhe AY; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States., Dadi PK; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States., Kim J; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.; Department of Chemistry, Vanderbilt University, Nashville, United States., Dickerson MT; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States., Behera S; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States., Dobson JR; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States., Shrestha S; Center for Stem Cell Biology, Vanderbilt University, Nashville, United States., Cartailler JP; Center for Stem Cell Biology, Vanderbilt University, Nashville, United States., Sampson L; Center for Stem Cell Biology, Vanderbilt University, Nashville, United States., Magnuson MA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.; Center for Stem Cell Biology, Vanderbilt University, Nashville, United States.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, United States., Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.

Publikováno v: ELife [Elife] 2024 May 03; Vol. 12. Date of Electronic Publication: 2024 May 03.

G i/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na ⁺ /K ⁺ ATPase activation.

Autor: Dickerson MT; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Dadi PK; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Zaborska KE; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Nakhe AY; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Schaub CM; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Dobson JR; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Wright NM; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Lynch JC; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Scott CF; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Robinson LD; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA., Jacobson DA; Molecular Physiology and Biophysics Department, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN, USA. david.a.jacobson@vanderbilt.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 29; Vol. 13 (1), pp. 6461. Date of Electronic Publication: 2022 Oct 29.

Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function.

Autor: Kuo T; Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY, USA. Electronic address: tk2592@cumc.columbia.edu., Du W; Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY, USA., Miyachi Y; Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY, USA., Dadi PK; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Segrè D; Department of Biology, Department of Biomedical Engineering, Department of Physics, Boston University, Boston, MA, USA., Accili D; Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Publikováno v: Molecular metabolism [Mol Metab] 2021 Nov; Vol. 53, pp. 101256. Date of Electronic Publication: 2021 May 25.

A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young.

Autor: Graff SM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Johnson SR; Department of Endocrinology, Queensland Children's Hospital, South Brisbane, Queensland, Australia.; Translational Genomics Group, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.; Faculty of Medicine, University of Queensland, Herston, Queensland, Australia., Leo PJ; Translational Genomics Group, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia., Dadi PK; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Dickerson MT; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Nakhe AY; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA., McInerney-Leo AM; Dermatology Research Centre, Dermatology Research Centre, The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia., Marshall M; Translational Genomics Group, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia., Zaborska KE; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Schaub CM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Brown MA; Guy's and St Thomas' NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, London, United Kingdom., Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Duncan EL; Faculty of Medicine, University of Queensland, Herston, Queensland, Australia.; Department of Twin Research & Genetic Epidemiology, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Publikováno v: JCI insight [JCI Insight] 2021 Jul 08; Vol. 6 (13). Date of Electronic Publication: 2021 Jul 08.

Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice.

Autor: Datta, Ananya¹ (AUTHOR) dattaa@neco.edu, Li, Xin Yi¹ (AUTHOR), Nagpaul, Manshul¹ (AUTHOR)

Publikováno v: PLoS ONE. 10/31/2024, Vol. 19 Issue 10, p1-23. 23p.