Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.

Autor: Youlten SE; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Kemp JP; University of Queensland Diamantina Institute, UQ, Brisbane, QLD, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Logan JG; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Ghirardello EJ; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Sergio CM; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Dack MRG; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Guilfoyle SE; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Leitch VD; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; RMIT Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne, VIC, UK., Butterfield NC; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Komla-Ebri D; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Chai RC; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Corr AP; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.; Faculty of Science, University of Bath, Bath, UK., Smith JT; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.; Faculty of Science, University of Bath, Bath, UK., Mohanty ST; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Morris JA; New York Genome Center, New York, NY, USA.; Faculty of Arts and Science, Department of Biology, New York University, New York, NY, USA., McDonald MM; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Quinn JMW; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., McGlade AR; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Bartonicek N; Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, NSW, Australia., Jansson M; Viapath Genetics Laboratory, Viapath Analytics LLP, Guy's Hospital, London, UK.; Department of Clinical Genetics, Guy's Hospital, London, UK., Hatzikotoulas K; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Phoenix, AZ, USA.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Irving MD; Department of Clinical Genetics, Guy's and St Thomas' NHS Trust, London, UK., Beleza-Meireles A; Department of Clinical Genetics, University Hospitals Bristol, Bristol, UK., Rivadeneira F; Department of Internal Medicine, Erasmus, MC, Rotterdam, the Netherlands., Duncan E; Faculty of Life Sciences and Medicine, Department of Twin Research & Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.; Australian Translational Genomics Centre, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.; Faculty of Medicine, University of Queensland, St Lucia, QLD, Australia., Richards JB; Faculty of Life Sciences and Medicine, Department of Twin Research & Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.; Faculty of Medicine, McGill University, Quebec, Canada., Adams DJ; Wellcome Sanger Institute, Hinxton, UK., Lelliott CJ; Wellcome Sanger Institute, Hinxton, UK., Brink R; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.; Division of Immunology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Phan TG; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.; Division of Immunology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Eisman JA; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.; School of Medicine Sydney, University of Notre Dame Australia, Fremantle, Australia., Evans DM; University of Queensland Diamantina Institute, UQ, Brisbane, QLD, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Phoenix, AZ, USA.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Baldock PA; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Bassett JHD; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. d.bassett@imperial.ac.uk., Williams GR; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. graham.williams@imperial.ac.uk., Croucher PI; Bone Biology, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia. p.croucher@garvan.org.au.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia. p.croucher@garvan.org.au.; School of Biotechnology and Biomolecular Sciences, UNSW Australia, Sydney, Australia. p.croucher@garvan.org.au.

Publikováno v: Nature communications [Nat Commun] 2021 May 05; Vol. 12 (1), pp. 2444. Date of Electronic Publication: 2021 May 05.

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.

Autor: McDonald MM; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Khoo WH; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Ng PY; Bone Biology & Disease Laboratory, School of Biomedical Sciences, University of Western Australia, Nedlands, WA, Australia., Xiao Y; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Zamerli J; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Thatcher P; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Kyaw W; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Pathmanandavel K; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Grootveld AK; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Moran I; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Butt D; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Nguyen A; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Corr A; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Warren S; Cancer, Garvan Institute of Medical Research, Sydney, NSW, Australia., Biro M; EMBL Australia, Single Molecule Science Node, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Butterfield NC; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK., Guilfoyle SE; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK., Komla-Ebri D; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK., Dack MRG; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK., Dewhurst HF; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK., Logan JG; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK., Li Y; John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Mohanty ST; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Byrne N; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Terry RL; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Simic MK; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Chai R; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Quinn JMW; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Youlten SE; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Pettitt JA; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Abi-Hanna D; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Jain R; Immune Imaging Program, Centenary Institute, Sydney, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia., Weninger W; Immune Imaging Program, Centenary Institute, Sydney, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Lundberg M; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba, QLD, Australia; Transformational Bioinformatics, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, Australia., Sun S; Biovinc, Pasadena, CA, USA., Ebetino FH; Biovinc, Pasadena, CA, USA., Timpson P; Cancer, Garvan Institute of Medical Research, Sydney, NSW, Australia., Lee WM; John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Baldock PA; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Rogers MJ; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia., Brink R; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia., Williams GR; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK., Bassett JHD; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK., Kemp JP; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba, QLD, Australia; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Pavlos NJ; Bone Biology & Disease Laboratory, School of Biomedical Sciences, University of Western Australia, Nedlands, WA, Australia., Croucher PI; Healthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia. Electronic address: p.croucher@garvan.org.au., Phan TG; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia. Electronic address: t.phan@garvan.org.au.

Publikováno v: Cell [Cell] 2021 Mar 04; Vol. 184 (5), pp. 1330-1347.e13. Date of Electronic Publication: 2021 Feb 25.