Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dacheng Ma"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Learning effective molecular feature representation to facilitate molecular property prediction is of great significance for drug discovery. Recently, there has been a surge of interest in pre-training graph neural networks (GNNs) via self-s
Externí odkaz:
https://doaj.org/article/3accf436897c4a61889717c8ff87427b
Autor:
Hongzhi Zeng, Qichen Yuan, Fei Peng, Dacheng Ma, Ananya Lingineni, Kelly Chee, Peretz Gilberd, Emmanuel C. Osikpa, Zheng Sun, Xue Gao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract DNA base editors use deaminases fused to a programmable DNA-binding protein for targeted nucleotide conversion. However, the most widely used TadA deaminases lack post-translational control in living cells. Here, we present a split adenine b
Externí odkaz:
https://doaj.org/article/291a130d24c14b498559b347e09f1a5a
Publikováno v:
Synthetic and Systems Biotechnology, Vol 8, Iss 3, Pp 371-377 (2023)
Prime editing is a revolutionary gene-editing method that is capable of introducing insertions, deletions and base substitutions into the genome. However, the editing efficiency of Prime Editor (PE) is limited by the DNA repair process. Here, we show
Externí odkaz:
https://doaj.org/article/b331be1c9402447aa7bcd3d3d944cf14
Autor:
Rongjie Fu, Wei He, Jinzhuang Dou, Oscar D. Villarreal, Ella Bedford, Helen Wang, Connie Hou, Liang Zhang, Yalong Wang, Dacheng Ma, Yiwen Chen, Xue Gao, Martin Depken, Han Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The sequence determinants governing CRISPR/Cas9 specificity are not fully understood. Here, the authors devise a high-throughput dual-target synthetic system to explore the sequence features associated with CRISPR/Cas9 off-target effect, reveal a set
Externí odkaz:
https://doaj.org/article/5fc93d0311ad442eb76be261e9de5028
Autor:
Dacheng Ma, Zhimeng Xu, Zhaoyu Zhang, Xi Chen, Xiangzhi Zeng, Yiyang Zhang, Tingyue Deng, Mengfei Ren, Zheng Sun, Rui Jiang, Zhen Xie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The genomic locations that can be targeted for editing by CRISPR are limited by the presence of the nuclease-specific PAM sequence. Here, the authors show PAM recognition can be expanded by replacing the key region in the PAM interaction domain of Sa
Externí odkaz:
https://doaj.org/article/d2dba04bf729424ba3ba8546bebedf29
Publikováno v:
Protein & Cell, Vol 8, Iss 5, Pp 379-393 (2017)
ABSTRACT Human pluripotent stem cells (hPSCs) are an important system to study early human development, model human diseases, and develop cell replacement therapies. However, genetic manipulation of hPSCs is challenging and a method to simultaneously
Externí odkaz:
https://doaj.org/article/f8030b06a134493ca3ce1cfcd32f1f64
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Molecular engineering of Cas9 has the potential to expand the application of CRISPR-Cas technology. Here, Ma et al. show that dCas9 can be split and reconstituted in human cells and use a domain swapping strategy to engineer custom Cas9-based logic c
Externí odkaz:
https://doaj.org/article/2b8fed1f7cda4027bcc187fdb24c9236
Autor:
Dacheng Ma, Qichen Yuan, Fei Peng, Victor Paredes, Hongzhi Zeng, Emmanuel C. Osikpa, Qiaochu Yang, Advaith Peddi, Anika Patel, Megan S. Liu, Zheng Sun, Xue Gao
Publikováno v:
J Am Chem Soc
Gene regulation via chemically induced dimerization (CID) is useful for biomedical research. However, the number, type, versatility, and in vivo applications of CID tools are limited. Here, we demonstrate proteolysis targeting chimeras-based scalable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8a6b209af09b03d5c09e1a62397b32
https://europepmc.org/articles/PMC10162582/
https://europepmc.org/articles/PMC10162582/
Publikováno v:
Canadian Journal of Physics. 99:998-1006
We connected the two ends of a finite spin-1/2 antiferromagnetic Ising chain with a magnetic impurity at one end to form a closed ring, and studied its magnetic susceptibility exactly by using the transfer matrix method. We calculated the magnetic su
Autor:
Rongjie Fu, Wei He, Jinzhuang Dou, Oscar D. Villarreal, Ella Bedford, Helen Wang, Connie Hou, Liang Zhang, Yalong Wang, Dacheng Ma, Yiwen Chen, Xue Gao, Martin Depken, Han Xu
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Nature Communications, 13(1)
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Nature Communications, 13(1)
The specificity of CRISPR/Cas9 genome editing is largely determined by the sequences of guide RNA (gRNA) and the targeted DNA, yet the sequence-dependent rules underlying off-target effects are not fully understood. To systematically explore the sequ