scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints

Autor: Dacanay Ea, Elvire Gouze, Ted A. Broome, Michael J. Dark, William W. Hauswirth, Jesse D Kay, Patrick T. Colahan, Jean Noel Gouze, David M. Nickerson, Padraic P. Levings, Andrew D. Smith, Rice B, Rachael S Watson, Steven C. Ghivizzani

Publikováno v: Gene therapy

With the long-term goal of developing a gene-based treatment for osteoarthritis (OA), we performed studies to evaluate the equine joint as a model for adeno-associated virus (AAV)-mediated gene transfer to large, weight-bearing human joints. A self-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85d02be561c24cec5ab513ef6058ce1
https://doi.org/10.1038/gt.2012.81

Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.

Autor: Watson Levings RS; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Broome TA; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Smith AD; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Rice BL; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Gibbs EP; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Myara DA; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Hyddmark EV; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Nasri E; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Zarezadeh A; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Levings PP; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Lu Y; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., White ME; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Dacanay EA; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Foremny GB; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Evans CH; 3 Rehabilitation Medicine Research Center, Mayo Clinic , Rochester, Minnesota., Morton AJ; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Winter M; 4 Department of Small Animal Clinical Sciences, University of Florida , Gainesville, Florida., Dark MJ; 5 Department of Infectious Diseases and Pathology, University of Florida , Gainesville, Florida., Nickerson DM; 6 Department of Statistics and Actuarial Science, University of Central Florida , Orlando, Florida., Colahan PT; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Ghivizzani SC; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida.

Publikováno v: Human gene therapy. Clinical development [Hum Gene Ther Clin Dev] 2018 Jun; Vol. 29 (2), pp. 90-100.

scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints.

Autor: Watson RS; Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL 32608-0137, USA., Broome TA, Levings PP, Rice BL, Kay JD, Smith AD, Gouze E, Gouze JN, Dacanay EA, Hauswirth WW, Nickerson DM, Dark MJ, Colahan PT, Ghivizzani SC

Publikováno v: Gene therapy [Gene Ther] 2013 Jun; Vol. 20 (6), pp. 670-7. Date of Electronic Publication: 2012 Nov 15.

Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta.

Autor: Gouze JN; Department of Orthopaedics and Rehabilitation, Gene Therapy Laboratory, University of Florida, College of Medicine, PO Box 100137, Gainesville, FL 32610-0137, USA. gouzej@ortho.ufl.edu, Gouze E, Popp MP, Bush ML, Dacanay EA, Kay JD, Levings PP, Patel KR, Saran JP, Watson RS, Ghivizzani SC

Publikováno v: Arthritis research & therapy [Arthritis Res Ther] 2006; Vol. 8 (6), pp. R173.