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Clinical Prediction Models Combining Routine Clinical Measures Have High Accuracy in Identifying Youth-Onset Type 2 Diabetes Defined by Maintained Endogenous Insulin Secretion: The SEARCH for Diabetes in Youth Study.

Autor: Jones AG; University of Exeter Medical School, Exeter, U.K., Shields BM; University of Exeter Medical School, Exeter, U.K., Oram RA; University of Exeter Medical School, Exeter, U.K., Dabelea DM; University of Colorado Anschutz Medical Campus, Aurora, CO., Hagopian WA; University of Washington, Seattle, WA., Lustigova E; Kaiser Permanente Southern California, Los Angeles, CA., Shah AS; University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Knupp J; University of Exeter Medical School, Exeter, U.K., Mottl AK; University of North Carolina at Chapel Hill, Chapel Hill, NC., D'Agostino RB; Wake Forest School of Medicine, Winston-Salem, NC., Williams A; Wake Forest School of Medicine, Winston-Salem, NC., Marcovina SM; Medpace Reference Laboratories, Cincinnati, OH., Pihoker C; University of Washington, Seattle, WA., Divers J; Wake Forest School of Medicine, Winston-Salem, NC., Redondo MJ; Baylor College of Medicine and Texas Children's Hospital, Houston, TX.

Publikováno v: Diabetes care [Diabetes Care] 2024 Jan 22. Date of Electronic Publication: 2024 Jan 22.

Exposure to Gestational Diabetes and BMI Trajectories Through Adolescence: The Exploring Perinatal Outcomes Among Children Study.

Autor: Hockett CW; Avera Research Institute, Sioux Falls, SD 57108, USA.; Department of Pediatrics, University of South Dakota School of Medicine, Sioux Falls, SD 57105, USA., Harrall KK; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, USA., Glueck DH; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA., Dabelea DM; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, USA.; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2023 Oct 18; Vol. 108 (11), pp. 2898-2906.

Evaluation of pediatric epigenetic clocks across multiple tissues.

Autor: Fang F; GenOmics and Translational Research Center, RTI International, Research Triangle Park, 3040 East Cornwallis Road, Durham, NC, 27709-2194, USA. ffang@rti.org., Zhou L; GenOmics and Translational Research Center, RTI International, Research Triangle Park, 3040 East Cornwallis Road, Durham, NC, 27709-2194, USA., Perng W; Department of Epidemiology, Colorado School of Public Health, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA., Marsit CJ; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Knight AK; Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA., Cardenas A; Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, USA., Aung MT; Division of Environmental Health, Department of Population and Populace Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hivert MF; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Aris IM; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA., Goodrich JM; Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA., Smith AK; Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Gaylord A; Department of Population Health, New York University School of Medicine, New York, NY, USA., Fry RC; Department of Environmental Sciences and Engineering, UNC-Chapel Hill, Chapel Hill, NC, USA., Oken E; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA., O'Connor G; Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Ruden DM; Department of Obstetrics and Gynecology, Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA., Trasande L; Department of Population Health, New York University School of Medicine, New York, NY, USA.; Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA., Herbstman JB; Mailman School of Public Health, Columbia University, New York, NY, USA., Camargo CA Jr; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Bush NR; Department of Psychiatry and Behavioral Sciences, Department of Pediatrics, University of California, San Francisco, CA, USA., Dunlop AL; Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA., Dabelea DM; Department of Epidemiology, Colorado School of Public Health, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA., Karagas MR; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Breton CV; Division of Environmental Health, Department of Population and Populace Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Ober C; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Everson TM; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Page GP; GenOmics and Translational Research Center, RTI International, Research Triangle Park, 3040 East Cornwallis Road, Durham, NC, 27709-2194, USA., Ladd-Acosta C; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Publikováno v: Clinical epigenetics [Clin Epigenetics] 2023 Sep 02; Vol. 15 (1), pp. 142. Date of Electronic Publication: 2023 Sep 02.

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.

Autor: Huerta-Chagoya A; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. ahuerta@broadinstitute.org.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. ahuerta@broadinstitute.org.; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico. ahuerta@broadinstitute.org.; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico. ahuerta@broadinstitute.org., Schroeder P; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Mandla R; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Deutsch AJ; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Zhu W; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Petty L; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Yi X; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium., Cole JB; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO, USA., Udler MS; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Dornbos P; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Porneala B; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., DiCorpo D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Li JH; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Szczerbiński L; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland., Kaur V; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Kim J; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Lu Y; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Martin A; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Eizirik DL; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.; WELBIO, Université Libre de Bruxelles, Brussels, Belgium., Marchetti P; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa, Italy., Marselli L; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa, Italy., Chen L; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Srinivasan S; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA., Todd J; Department of Pediatrics, University of Vermont, Burlington, VT, USA., Flannick J; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA., Gubitosi-Klug R; Pediatric Endocrinology, Diabetes, and Metabolism, Case Western Reserve University and Rainbow Babies and Children's Hospital, Cleveland, OH, USA., Levitsky L; Department of Pediatrics, Division of Pediatric Endocrinology and Pediatric Diabetes Center, Massachusetts General Hospital, Boston, MA, USA., Shah R; Pediatric Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kelsey M; Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA., Burke B; Biostatistics Center, The George Washington University, Rockville, MD, USA., Dabelea DM; Department of Epidemiology, University of Colorado School of Medicine, Aurora, CO, USA., Divers J; NYU Langone Health, New York, NY, USA., Marcovina S; Medpace Reference Laboratories, Cincinnati, OH, USA., Stalbow L; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Loos RJF; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark., Darst BF; Division of Public Health Science, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kooperberg C; Division of Public Health Science, Fred Hutchinson Cancer Center, Seattle, WA, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Haiman C; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Sun Q; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., McCormick JB; School of Public Health, The University of Texas Health Science Center at Houston, Brownsville, TX, USA., Fisher-Hoch SP; School of Public Health, The University of Texas Health Science Center at Houston, Brownsville, TX, USA., Ordoñez ML; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico., Meigs J; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Baier LJ; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA., González-Villalpando C; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico., González-Villalpando ME; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico., Orozco L; Laboratorio Inmunogénomica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., García-García L; Instituto Nacional de Salud Pública, Cuernavaca, Mexico., Moreno-Estrada A; Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Unidad de Genómica Avanzada (UGA), CINVESTAV, Irapuato, Mexico., Aguilar-Salinas CA; Unidad de Investigación de Enfermedades Metabólicas y Dirección de Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Tusié T; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Ng MCY; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Manning A; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA., Highland HM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Cnop M; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.; Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles, Brussels, Belgium., Hanson R; Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA., Below J; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Florez JC; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Endocrine Division, Massachusetts General Hospital, Boston, MA, USA., Leong A; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.; Endocrine Division, Massachusetts General Hospital, Boston, MA, USA., Mercader JM; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. mercader@broadinstitute.org.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. mercader@broadinstitute.org.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA. mercader@broadinstitute.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. mercader@broadinstitute.org.

Publikováno v: Diabetologia [Diabetologia] 2023 Jul; Vol. 66 (7), pp. 1273-1288. Date of Electronic Publication: 2023 May 06.