Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Daan van der Es"'
Autor:
Natalia V. Ortiz Zacarías, Sascha Röth, Jeremy D. Broekhuis, Daan van der Es, Kevin Moreau, Laura H. Heitman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8984 (2024)
CC chemokine receptor 2 (CCR2) has been linked to many inflammatory and immune diseases, making it a relevant drug target. Yet, all CCR2 antagonists developed so far have failed in clinical trials; thus, novel strategies are needed to target this rec
Externí odkaz:
https://doaj.org/article/6db528a29d49459988b2161f531381fd
Autor:
Jacopo Enotarpi, Marta Tontini, Cristiana Balocchi, Daan van der Es, Ludovic Auberger, Evita Balducci, Filippo Carboni, Daniela Proietti, Daniele Casini, Dmitri V. Filippov, Hermen S. Overkleeft, Gijsbert A. van der Marel, Cinzia Colombo, Maria Rosaria Romano, Francesco Berti, Paolo Costantino, Jeroen D. C. Codeé, Luigi Lay, Roberto Adamo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) is a component of commercial vaccines, but is unstable. Here, the authors generate glycomimetic oligomers that demonstrate higher stability than their natural counterparts and
Externí odkaz:
https://doaj.org/article/1d2c58955e994faaa3143dcfc9de2b58
Autor:
Jacopo Enotarpi, Marta Tontini, Cristiana Balocchi, Daan van der Es, Ludovic Auberger, Evita Balducci, Filippo Carboni, Daniela Proietti, Daniele Casini, Dmitri V. Filippov, Hermen S. Overkleeft, Gijsbert A. van der Marel, Cinzia Colombo, Maria Rosaria Romano, Francesco Berti, Paolo Costantino, Jeroen D. C. Codeé, Luigi Lay, Roberto Adamo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20120-4
Externí odkaz:
https://doaj.org/article/6e85ff5c9a9e45488634b1c6af5a7044
Autor:
Bert Beerkens, Inge Snijders, Joep Snoeck, Rongfang Liu, Anton Tool, Sylvia Le Dévédec, Willem Jespers, Taco Kuijpers, Gerard van Westen, Laura Heitman, Adriaan IJzerman, Daan van der Es
The adenosine A3 receptor (A3AR) is a G protein-coupled receptor (GPCR) that exerts immunomodulatory effects in pathophysiological conditions such as inflammation and cancer. Thus far, studies towards the downstream effects of A3AR activation have yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::632e1b6b743288d318a42355973e30fa
https://doi.org/10.26434/chemrxiv-2023-6g59z
https://doi.org/10.26434/chemrxiv-2023-6g59z
Autor:
Bert L H, Beerkens, Çağla, Koç, Rongfang, Liu, Bogdan I, Florea, Sylvia E, Le Dévédec, Laura H, Heitman, Adriaan P, IJzerman, Daan, van der Es
Publikováno v:
ACS chemical biology. 17(11)
G protein-coupled receptors (GPCRs) have been known for decades as attractive drug targets. This has led to the development and approval of many ligands targeting GPCRs. Although ligand binding effects have been studied thoroughly for many GPCRs, the
Autor:
Jesús Jiménez-Barbero, Suzana Malić, Stipan Jonjić, Ana M Gimeno Cardells, Roberto Adamo, Daan van der Es, Herman S. Overkleeft, Angela van Diepen, Filippo Carboni, Francesca Berni, Sara Ali, Ermioni Kalfopoulou, Felipe Romero-Saavedra, Cornelis H. Hokke, Tihana Lenac Rovis, Johannes Huebner, Gijsbert A. van der Marel, Jeroen D. C. Codée, Karmela Miklić, Diana Laverde
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 16(8), 1344-1349
Volume 16
Issue 8
ACS Chemical Biology, 16(8), 1344-1349. AMER CHEMICAL SOC
ACS Chemical Biology, 16(8), 1344-1349
Volume 16
Issue 8
ACS Chemical Biology, 16(8), 1344-1349. AMER CHEMICAL SOC
Glycerol phosphate (GroP)-based teichoic acids (TAs) are antigenic cell-wall components found in both enterococcus and staphylococcus species. Their immunogenicity has been explored using both native and synthetic structures, but no details have yet
Autor:
Tasia, Amelia, Jacobus P D, van Veldhoven, Matteo, Falsini, Rongfang, Liu, Laura H, Heitman, Gerard J P, van Westen, Elena, Segala, Grégory, Verdon, Robert K Y, Cheng, Robert M, Cooke, Daan, van der Es, Adriaan P, IJzerman
Publikováno v:
Journal of Medicinal Chemistry
In this study, we determined the crystal structure of an engineered human adenosine A2A receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction betw
Autor:
Tasia Amelia, Robert K. Y. Cheng, Gerard J. P. van Westen, Rongfang Liu, Elena Segala, Robert M. Cooke, Laura H. Heitman, Jacobus P. D. van Veldhoven, Daan van der Es, Matteo Falsini, Grégory Verdon, Adriaan P. IJzerman
Publikováno v:
Journal of Medicinal Chemistry, 64(7), 3827-3842. American Chemical Society (ACS)
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
In this study, we determined the crystal structure of an engineered human adenosine A2A receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3eaee9ee24339f7b4772a78e3323223
http://hdl.handle.net/1887/3204468
http://hdl.handle.net/1887/3204468
Autor:
Adriaan P. IJzerman, Daan van der Es, Emy Theunissen, Laura H. Heitman, Natalia V. Ortiz Zacarías, Lloyd Mallee, Tracy M. Handel, Yi Zheng, Irina Kufareva, Tereza Šimková, Cas van der Horst, Asuka Inoue, Julien Louvel, Kirti Kandhwal Chahal
Publikováno v:
Journal of Medicinal Chemistry, 64(5), 2608-2621. American Chemical Society (ACS)
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Covalently acting inhibitors constitute a large and growing fraction of approved small-molecule therapeutics as well as useful tools for a variety of in vitro and in vivo applications. Here, we aimed to develop a covalent antagonist of CC chemokine r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4389804a300c8dfc34d46501d3715b
https://doi.org/10.1021/acs.jmedchem.0c01137
https://doi.org/10.1021/acs.jmedchem.0c01137
Autor:
Johannes Huebner, Gijsbert A. van der Marel, Herman S. Overkleeft, Daan van der Es, Francesca Berni, Angela van Diepen, Ermioni Kalfopoulou, D. Linh Nguyen, Jeroen D. C. Codée, Liming Wang, Cornelis H. Hokke
Publikováno v:
RSC Chemical Biology, 2(1), 187-191. ROYAL SOC CHEMISTRY
Lipoteichoic acids (LTAs) have been addressed as possible antigen candidates for vaccine development against several opportunistic Gram-positive pathogens. The study of structure-immunogenicity relationship represents a challenge due to the heterogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6922f5df1a8151545926d5fc85047ff
https://doi.org/10.1039/d0cb00206b
https://doi.org/10.1039/d0cb00206b