A retrospective multicenter study on clinical and serological parameters in patients with MuSK myasthenia gravis with and without general immunosuppression

Autor: Inga Koneczny, Marina Mané-Damas, Shenghua Zong, Sander De Haas, Saif Huda, Daan van Kruining, Jan Damoiseaux, Anna De Rosa, Michelangelo Maestri, Melania Guida, Peter Molenaar, Philip Van Damme, Andreas Fichtenbaum, Thomas Perkmann, Marc De Baets, Konstantinos Lazaridis, Vasiliki Zouvelou, Socrates Tzartos, Roberta Ricciardi, Mario Losen, Pilar Martinez-Martinez

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionMuscle-specific kinase (MuSK)- myasthenia gravis (MG) is caused by pathogenic autoantibodies against MuSK that correlate with disease severity and are predominantly of the IgG4 subclass. The first-line treatment for MuSK-MG is general imm

Externí odkaz: https://doaj.org/article/c2c004998c4f40fd8460fa0a2d8a4cfa

Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder.

Autor: Carolin Hoffmann, Jo Stevens, Shenghua Zong, Daan van Kruining, Abhishek Saxena, Cem İsmail Küçükali, Erdem Tüzün, Nazlı Yalçınkaya, Marc De Hert, Emiliano González-Vioque, Celso Arango, Jon Lindstrom, Marc H De Baets, Bart P F Rutten, Jim van Os, Peter Molenaar, Mario Losen, Pilar Martinez-Martinez

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0208412 (2018)

The α7 acetylcholine receptor (AChR) has been linked with the onset of psychotic symptoms and we hypothesized therefore that it might also be an autoimmune target. Here, we describe a new radioimmunoassay (RIA) using iodine 125-labelled α-bungaroto

Externí odkaz: https://doaj.org/article/fdadb8981e9a480eb87acf75812498f0

Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods

Autor: Tiago Gil Oliveira, Daan van Kruining, Andrew P. Bowman, Qian Luo, Shane R. Ellis, Gerhild van Echten-Deckert, Pilar Martinez-Martinez, Michelle M. Mielke

Publikováno v: Advanced drug delivery reviews

Lipids play an important role in neurodegeneration, neuroinflammation, and psychiatric disorders and an imbalance in sphingolipid levels is associated with disease. Although early diagnosis and intervention of these disorders would clearly have favor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30e03103a3e81d07e7d5e307550585b
https://doi.org/10.1016/j.addr.2020.04.009

CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease

Autor: Daan van Kruining, Anna-Lena Scheithauer, Pilar Martinez-Martinez, Barbara Hobo, Jochen Walter, Dušan Berkeš, Christopher Exley, Kristiaan Wouters, Mario Losen, Joost Verhaagen, Sandra den Hoedt, Caterina Giovagnoni, Maria Dolores Ledesma, Qian Luo, Matthew Mold, Michelle M. Mielke, Gerard H. Bode, Daniel L.A. van den Hove, Simone M. Crivelli, Jo Stevens, Helga E. de Vries, Erhard Bieberich, Monique T. Mulder

Publikováno v: Crivelli, S M, Luo, Q, Stevens, J A A, Giovagnoni, C, van Kruining, D, Bode, G, den Hoedt, S, Hobo, B, Scheithauer, A L, Walter, J, Mulder, M T, Exley, C, Mold, M, Mielke, M M, De Vries, H E, Wouters, K, van den Hove, D L A, Berkes, D, Ledesma, M D, Verhaagen, J, Losen, M, Bieberich, E & Martinez-Martinez, P 2021, ' CERT L reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease ', Alzheimer's Research and Therapy, vol. 13, no. 1, 45 . https://doi.org/10.1186/s13195-021-00780-0
Alzheimer's Research & Therapy, 13(1):45. BioMed Central Ltd
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-21 (2021)
Alzheimer's Research & Therapy, 13(1). BioMed Central
Alzheimer's Research and Therapy, 13(1):45. BioMed Central Ltd.
Alzheimer's Research and Therapy, 13(1):45. BioMed Central

BackgroundDysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide transfer proteins (CERTs) are ceramide carriers which are crucial for ceramide and sphingomyeli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b490674ef4af7463e3b1e3e2ba1ec9
https://research.vu.nl/en/publications/4861577e-37b2-44d3-a5fe-3bb6f591f79f

Rapid Visualization of Chemically Related Compounds Using Kendrick Mass Defect As a Filter in Mass Spectrometry Imaging

Autor: Daan van Kruining, Mathieu Tiquet, La Rocca Raphaël, Edwin De Pauw, Christopher Kune, Marc Ongena, Anthony Arguelles Arias, Gauthier Eppe, Pilar Martinez Martinez, Loïc Quinton, Johann Far, Andréa McCann

Publikováno v: Analytical Chemistry, 91(20), 13112-13118. American Chemical Society
Analytical Chemistry

Kendrick mass defect (KMD) analysis is widely used for helping the detection and identification of chemically related compounds based on exact mass measurements. We report here the use of KMD as a criterion for filtering complex mass spectrometry dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1835cb4ba1d7c857b1f73af9f2ab39a5
https://doi.org/10.1021/acs.analchem.9b03333