SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells.

Autor: Daan van Abel, Dennis R Hölzel, Shushant Jain, Fiona M F Lun, Yama W L Zheng, Eric Z Chen, Hao Sun, Rossa W K Chiu, Y M Dennis Lo, Marie van Dijk, Cees B M Oudejans

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e21994 (2011)

BackgroundIn this study, we performed a genome-wide search for effector genes bound by STOX1A, a winged helix transcription factor recently demonstrated to be involved in late onset Alzheimer's disease and affecting the amyloid processing pathway.Met

Externí odkaz: https://doaj.org/article/f1ff01424925411ea32e35d5eec9667e

Stox1 as a novel transcriptional suppressor of Math1 during cerebellar granule neurogenesis and medulloblastoma formation

Autor: Minglei Wang, Zhongzhong Ji, Weiwei Zhang, Rong Yang, Xiaohang Yang, Chenlu Zhang, Marie van Dijk, Huanping An, Ru Yang, Daan van Abel, Wei-Qiang Gao, Helen He Zhu, Guangshuo Ou

Publikováno v: Cell Death and Differentiation, 23(12), 2042-2053. Nature Publishing Group
Zhang, C, Ji, Z, Wang, M, Zhang, W, Yang, R, An, H, Yang, R, van Abel, D, van Dijk, M, Yang, X, Ou, G, Zhu, H H & Gao, W-Q 2016, ' Stox1 as a novel transcriptional suppressor of Math1 during cerebellar granule neurogenesis and medulloblastoma formation ', Cell Death and Differentiation, vol. 23, no. 12, pp. 2042-2053 . https://doi.org/10.1038/cdd.2016.85

Cerebellar granule neuronal progenitors (GNPs) are the precursors of cerebellar granule cells (CGCs) and are believed to be the cell of origin for medulloblastoma (MB), yet the molecular mechanisms governing GNP neurogenesis are poorly elucidated. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01660d7cad92809c2b6e033c28fccdf5
https://research.vumc.nl/en/publications/89c4e4ed-c4f8-4e0e-b8a0-6832500cce7f

STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease

Autor: Marie van Dijk, Daan van Abel, Cees B.M. Oudejans, Wiep Scheper, Omar Abdul-Hamid

Publikováno v: Neuroscience Letters, 528(2), 104-109. Elsevier Ireland Ltd
Neuroscience letters, 528(2), 104-109. Elsevier Ireland Ltd
van Abel, D, Abdulhamid, O, Scheper, W, van Dijk, M & Oudejans, C B M 2012, ' STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease ', Neuroscience Letters, vol. 528, no. 2, pp. 104-109 . https://doi.org/10.1016/j.neulet.2012.09.017

Intraneuronal fibrillary tangles are a major hallmark of several neurodegenerative diseases including Alzheimer's disease. The major constituents of these hallmarks are hyper-phosphorylated tau. In this study we used a neuronal cellular model which o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766846528ccf7117d266668816b6736e
https://research.vumc.nl/en/publications/b0b86e12-19a9-4416-8b5a-06594cf88c3c

SFRS7-Mediated Splicing of Tau Exon 10 Is Directly Regulated by STOX1A in Glial Cells

Autor: Cees B.M. Oudejans, Rossa W.K. Chiu, Marie van Dijk, Yama W. L. Zheng, Eric Z. Chen, Dennis R. Hölzel, Daan van Abel, Shushant Jain, Fiona M.F. Lun, Hao Sun, Y.M. Dennis Lo

Publikováno v: PLoS ONE
PLoS ONE, 6(7):e21994. Public Library of Science
van Abel, D, Holzel, D R, Jain, S, Lun, F M F, Zheng, Y M W L, Chen, E Z, Sun, H, Chiu, R W K, Lo, Y M D, van Dijk, M & Oudejans, C B M 2011, ' SFRS7-Mediated Splicing of Tau Exon 10 Is Directly Regulated by STOX1A in Glial Cells ', PLoS ONE, vol. 6, no. 7, e21994 . https://doi.org/10.1371/journal.pone.0021994
PLoS ONE, Vol 6, Iss 7, p e21994 (2011)

BackgroundIn this study, we performed a genome-wide search for effector genes bound by STOX1A, a winged helix transcription factor recently demonstrated to be involved in late onset Alzheimer's disease and affecting the amyloid processing pathway.Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54288e77980c5789ec0bba99681913b8
http://europepmc.org/articles/PMC3130792

The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation

Autor: Jan van Bezu, Marie van Dijk, Daan van Abel, Cees B.M. Oudejans, Caroline Dunk, Stephen J. Lye, Marinus A. Blankenstein

Publikováno v: Human Molecular Genetics, 19(13), 2658-2667. Oxford University Press
Human molecular genetics, 19(13), 2658-2667. Oxford University Press
van Dijk, M, van Bezu, J, van Abel, D, Dunk, C, Blankenstein, M A, Oudejans, C B M & Lye, S J 2010, ' The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation ', Human Molecular Genetics, vol. 19, no. 13, pp. 2658-2667 . https://doi.org/10.1093/hmg/ddq152

By using complementary in vitro and ex vivo approaches, we show that the risk allele (Y153H) of the pre-eclampsia susceptibility gene STOX1 negatively regulates trophoblast invasion by upregulation of the cell-cell adhesion protein alpha-T-catenin (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd423a85f0a59bcf1dbf32e0ca553e31
https://research.vumc.nl/en/publications/1478fe34-af7f-4761-a2e5-4d544ae1cd4e