Impact of obesity and roux‐en‐Y gastric bypass on the pharmacokinetics of (R)‐ and (S)‐omeprazole and intragastric pH

Autor: Leandro F. Pippa, Valvanera Vozmediano, Lieke Mitrov‐Winkelmolen, Daan Touw, Amira Soliman, Rodrigo Cristofoletti, Wilson Salgado Junior, Natalia Valadares de Moraes

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1528-1541 (2024)

Abstract This study employed physiologically‐based pharmacokinetic–pharmacodynamics (PBPK/PD) modeling to predict the effect of obesity and gastric bypass surgery on the pharmacokinetics and intragastric pH following omeprazole treatment. The sim

Externí odkaz: https://doaj.org/article/5a65cde4a533494db54a046517658249

Pharmacokinetic Boosting of Kinase Inhibitors

Autor: Niels Westra, Daan Touw, Marjolijn Lub-de Hooge, Jos Kosterink, Thijs Oude Munnink

Publikováno v: Pharmaceutics, Vol 15, Iss 4, p 1149 (2023)

(1) Introduction: Pharmacokinetic boosting of kinase inhibitors can be a strategy to enhance drug exposure and to reduce dose and associated treatment costs. Most kinase inhibitors are predominantly metabolized by CYP3A4, enabling boosting using CYP3

Externí odkaz: https://doaj.org/article/dfa3f1ad0cad4ef992c575258711783a

Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate

Autor: Marga Nijenhuis, Bianca Soree, Wafa O. M. Jama, Nienke J. de Boer-Veger, Anne Marie Buunk, Henk-Jan Guchelaar, Elisa J. F. Houwink, Gerard A. Rongen, Ron H. N. van Schaik, Jesse J. Swen, Daan Touw, Jan van der Weide, Roos van Westrhenen, Vera H. M. Deneer, Arne Risselada

Publikováno v: European Journal of Human Genetics. SPRINGERNATURE
European Journal of Human Genetics
European Journal of Human Genetics. Nature Publishing Group

Pharmacogenetics (PGx) studies the effect of heritable genetic variation on drug response. Clinical adoption of PGx has remained limited, despite progress in the field. To promote implementation, the Dutch Pharmacogenetics Working Group (DPWG) develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f755520f566484b90f85d4cb382e207
http://hdl.handle.net/1887/3515272

Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate

Autor: Marga, Nijenhuis, Bianca, Soree, Wafa O M, Jama, Nienke J, de Boer-Veger, Anne Marie, Buunk, Henk-Jan, Guchelaar, Elisa J F, Houwink, Gerard A, Rongen, Ron H N, van Schaik, Jesse J, Swen, Daan, Touw, Jan, van der Weide, Roos, van Westrhenen, Vera H M, Deneer, Arne, Risselada

Publikováno v: European journal of human genetics : EJHG.

Pharmacogenetics (PGx) studies the effect of heritable genetic variation on drug response. Clinical adoption of PGx has remained limited, despite progress in the field. To promote implementation, the Dutch Pharmacogenetics Working Group (DPWG) develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37f61e3e151b32090f34abb8252ca479
https://pubmed.ncbi.nlm.nih.gov/36509836

SGLT2 Inhibition and Uric Acid Excretion in Patients with Type 2 Diabetes and Normal Kidney Function

Autor: Danii L.S. Suijk, Michaël J.B. van Baar, Erik J.M. van Bommel, Zainab Iqbal, Merle M. Krebber, Volker Vallon, Daan Touw, Ewout J. Hoorn, Max Nieuwdorp, Mark M.H. Kramer, Jaap A. Joles, Petter Bjornstad, Daniël H. van Raalte

Publikováno v: Clinical journal of the American Society of Nephrology : CJASN, 17(5), 663-671. AMER SOC NEPHROLOGY
Clinical Journal of the American Society of Nephrology, 17(5), 663-671. American Society of Nephrology
Clin J Am Soc Nephrol
Clinical journal of the American Society of Nephrology, 17(5), 663-671. American Society of Nephrology

Background and objectives Sodium-glucose transporter 2 (SGLT2) inhibitor–induced uric acid lowering may contribute to kidney-protective effects of the drug class in people with type 2 diabetes. This study investigates mechanisms of plasma uric acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f093cfe410e80a96d74efcfec213ab
https://research.rug.nl/en/publications/027ee923-755b-4586-b6ed-604fedf8fee8