Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daan M. Van Den Brink"'
Autor:
Victor Girard, Florence Jollivet, Oskar Knittelfelder, Marion Celle, Jean-Noel Arsac, Gilles Chatelain, Daan M Van den Brink, Thierry Baron, Andrej Shevchenko, Ronald P Kühnlein, Nathalie Davoust, Bertrand Mollereau
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009921 (2021)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein (αSyn) aggregation and associated with abnormalities in lipid metabolism. The accumulation of lipids in cytoplasmic organelles called lipid droplets (LDs) was
Externí odkaz:
https://doaj.org/article/703475648ac1456b96f0b77a62b8af93
Autor:
Daan M Van Den Brink, Aurélie Cubizolle, Gilles Chatelain, Nathalie Davoust, Victor Girard, Simone Johansen, Francesco Napoletano, Pierre Dourlen, Laurent Guillou, Claire Angebault-Prouteau, Nathalie Bernoud-Hubac, Michel Guichardant, Philippe Brabet, Bertrand Mollereau
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007627 (2018)
Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in retinal diseases such as age-related macular degeneration and in brain disorders such as Alzheimer's and Parkinson's diseases. Lipid storage o
Externí odkaz:
https://doaj.org/article/583c7ba5db254940ae13c93c89fe26c6
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64427 (2013)
Nervous system function requires that neurons within neural circuits are connected together precisely. These connections form during the process of axon guidance whereby each neuron extends an axon that migrates, often large distances, through a comp
Externí odkaz:
https://doaj.org/article/a0a9b874113d4624aba535efc0bacf76
Autor:
Thierry Baron, Gilles Chatelain, Oskar Knittelfelder, Andrej Shevchenko, Bertrand Mollereau, Florence Jollivet, Victor Girard, Nathalie Davoust, Daan M. Van den Brink, Jean-Noël Arsac
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein (αSyn) aggregation and associated with abnormalities in lipid metabolism. The accumulation of lipids in cytoplasmic organelles called lipid droplets (LDs) wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e332e97d482347ed8f874769fbd8db0
https://doi.org/10.1101/2020.09.16.299354
https://doi.org/10.1101/2020.09.16.299354
Autor:
Michel Guichardant, Laurent Guillou, Victor Girard, Bertrand Mollereau, Nathalie Bernoud-Hubac, Aurélie Cubizolle, Daan M. Van Den Brink, Claire Angebault-Prouteau, Pierre Dourlen, Gilles Chatelain, Philippe Brabet, Francesco Napoletano, Simone Johansen, Nathalie Davoust
Publikováno v:
PLoS Genetics
PLoS Genetics, Public Library of Science, 2018, 14 (9), pp.25. ⟨10.1371/journal.pgen.1007627⟩
Plos Genetics 9 (14), . (2018)
PLoS Genetics, 2018, 14 (9), pp.25. ⟨10.1371/journal.pgen.1007627⟩
PLoS Genetics, Vol 14, Iss 9, p e1007627 (2018)
PLoS Genetics, Public Library of Science, 2018, 14 (9), pp.25. ⟨10.1371/journal.pgen.1007627⟩
Plos Genetics 9 (14), . (2018)
PLoS Genetics, 2018, 14 (9), pp.25. ⟨10.1371/journal.pgen.1007627⟩
PLoS Genetics, Vol 14, Iss 9, p e1007627 (2018)
Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in retinal diseases such as age-related macular degeneration and in brain disorders such as Alzheimer’s and Parkinson’s diseases. Lipid stora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7034e8ff375ee004c60955f9a863ba94
https://hal.archives-ouvertes.fr/hal-02003575
https://hal.archives-ouvertes.fr/hal-02003575
Autor:
Kieren D E Boardman, Michael D. Threadgill, Daan M. van den Brink, Matthew D. Lloyd, Andrew Smith, Ronald J.A. Wanders
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry, 22(5), 584-590. Informa Healthcare
Fatty aldehyde dehydrogenase (FALDH) is an NAD+-dependent oxidoreductase involved in the metabolism of fatty alcohols. Enzyme activity has been implicated in the pathology of diabetes and cancer. Mutations in the human gene inactivate the enzyme and
Autor:
Daan M. van den Brink, Jean-François Rontani, Joram N. I. van Miert, Georges Dacremont, Ronald J.A. Wanders
Publikováno v:
Journal of biological chemistry, 280(29), 26838-26844. American Society for Biochemistry and Molecular Biology Inc.
Phytol is a branched-chain fatty alcohol that is a naturally occurring precursor of phytanic acid, a fatty acid involved in the pathogenesis of Refsum disease. The conversion of phytol into phytanic acid is generally believed to take place via three
Autor:
Ronald J.A. Wanders, Daan M. van den Brink, Georges Dacremont, Gerbert A. Jansen, Joram N. I. van Miert, Jean-François Rontani
Publikováno v:
Molecular genetics and metabolism, 82(1), 33-37. Academic Press Inc.
Phytol is a branched chain fatty alcohol, which is abundantly present in nature as part of the chlorophyll molecule. In its free form, phytol is metabolized to phytanic acid, which accumulates in patients suffering from a variety of peroxisomal disor
Autor:
Anthony S. Wierzbicki, Jacqueline de Belleroche, Daan M. van den Brink, Pedro Brites, Janet Haasjes, Hans R. Waterham, Michelle Lambert-Hamill, John Mitchell, Gerbert A. Jansen, Ronald J.A. Wanders
Publikováno v:
Advances in experimental medicine and biology, 544, 69-70. Springer New York
American journal of human genetics, 72(2), 471-477. Cell Press
American Journal of Human Genetics, 72(2), 471-477. Cell Press
American journal of human genetics, 72(2), 471-477. Cell Press
American Journal of Human Genetics, 72(2), 471-477. Cell Press
Patients affected with Refsum disease (RD) have elevated levels of phytanic acid due to a deficiency of the peroxisomal enzyme phytanoyl-CoA hydroxylase (PhyH). In most patients with RD, disease-causing mutations in the PHYH gene have been identified
Publikováno v:
Clinical chemistry, 51(1), 240-242. American Association for Clinical Chemistry Inc.
Sjogren–Larsson syndrome (SLS) is a metabolic disorder characterized by an accumulation of long-chain fatty alcohols in plasma (1)(2). Studies by Rizzo and coworkers (3)(4)(5) have identified the enzyme that is deficient in SLS as fatty aldehyde de