Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Daan M. F. Van Aalten"'
Autor:
Florence Authier, Nina Ondruskova, Andrew T. Ferenbach, Alison D. McNeilly, Daan M. F. van Aalten
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/efc22cabbb364e4299dad3bb5b55dac5
Autor:
Leandro R. Soria, Georgios Makris, Alfonso M. D’Alessio, Angela De Angelis, Iolanda Boffa, Veronica M. Pravata, Véronique Rüfenacht, Sergio Attanasio, Edoardo Nusco, Paola Arena, Andrew T. Ferenbach, Debora Paris, Paola Cuomo, Andrea Motta, Matthew Nitzahn, Gerald S. Lipshutz, Ainhoa Martínez-Pizarro, Eva Richard, Lourdes R. Desviat, Johannes Häberle, Daan M. F. van Aalten, Nicola Brunetti-Pierri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Hyperammonemia occurs in liver diseases affecting ureagenesis, and is life-threatening. Here, the authors show that liver UDP-GlcNAc is increased during hyperammonemia, leading to O-GlcNAcylation of the rate-limiting ureagenesis enzyme CPS1, that enh
Externí odkaz:
https://doaj.org/article/f7dd4ac66ee843bca09996d7cef4b0de
Autor:
Michaela Omelková, Christina Dühring Fenger, Marta Murray, Trine Bjørg Hammer, Veronica M. Pravata, Sergio Galan Bartual, Ignacy Czajewski, Allan Bayat, Andrew T. Ferenbach, Marios P. Stavridis, Daan M. F. van Aalten
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/6c57373f8d2a40f7b2a046c323d0064e
Autor:
Yao Zhou, Kaizhou Yan, Qijian Qin, Olawale G. Raimi, Chao Du, Bin Wang, Chukwuemeka Samson Ahamefule, Bartosz Kowalski, Cheng Jin, Daan M. F. van Aalten, Wenxia Fang
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Aspergillus fumigatus is a devastating opportunistic fungal pathogen causing hundreds of thousands of deaths every year. Phosphoglucose isomerase (PGI) is a glycolytic enzyme that converts glucose-6-phosphate to fructose-6-phosphate, a key p
Externí odkaz:
https://doaj.org/article/35b7683a45a5434ca20a82b41dcf8cdb
Autor:
Wenxia Fang, Ana Belén Sanz, Sergio Galan Bartual, Bin Wang, Andrew T. Ferenbach, Vladimír Farkaš, Ramon Hurtado-Guerrero, Javier Arroyo, Daan M. F. van Aalten
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Transglycosylases strengthen the fungal cell wall by forming a rigid network of crosslinks. Here, Fang et al. show that the five Crh transglycosylases of Aspergillus fumigatus are dispensable for cell wall integrity in vitro, and solve the crystal st
Externí odkaz:
https://doaj.org/article/4d8d21ce0ca04436bd06a9ebe173e048
Autor:
Zhanliang Liu, Laurie M. Gay, Tina R. Tuveng, Jane W. Agger, Bjørge Westereng, Geir Mathiesen, Svein J. Horn, Gustav Vaaje-Kolstad, Daan M. F. van Aalten, Vincent G. H. Eijsink
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Enzymatic conversion of chitin, a β-1,4 linked polymer of N-acetylglucosamine, is of major interest in areas varying from the biorefining of chitin-rich waste streams to understanding how medically relevant fungi remodel their chitin-contai
Externí odkaz:
https://doaj.org/article/f472978cdfdc47b99927ec6827d307b8
Autor:
Villo Muha, Ritchie Williamson, Rachel Hills, Alison D. McNeilly, Thomas G. McWilliams, Jana Alonso, Marianne Schimpl, Aneika C. Leney, Albert J. R. Heck, Calum Sutherland, Kevin D. Read, Rory J. McCrimmon, Simon P. Brooks, Daan M. F. van Aalten
Publikováno v:
Open Biology, Vol 9, Iss 11 (2019)
O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain la
Externí odkaz:
https://doaj.org/article/9e64e5af2f29476f9e4eeb84d52a4cc3
Autor:
Karim Rafie, Olawale Raimi, Andrew T. Ferenbach, Vladimir S. Borodkin, Vaibhav Kapuria, Daan M. F. van Aalten
Publikováno v:
Open Biology, Vol 7, Iss 6 (2017)
O-linked N-acetylglucosamine (O-GlcNAc) is an essential and dynamic post-translational modification found on hundreds of nucleocytoplasmic proteins in metazoa. Although a single enzyme, O-GlcNAc transferase (OGT), generates the entire cytosolic O-Glc
Externí odkaz:
https://doaj.org/article/21a9f124fabb4a7cbe3a2df051cdbdb9
Autor:
Daniel Mariappa, Xiaowei Zheng, Marianne Schimpl, Olawale Raimi, Andrew T. Ferenbach, H.-Arno J. Müller, Daan M. F. van Aalten
Publikováno v:
Open Biology, Vol 5, Iss 12 (2015)
Post-translational modification of intracellular proteins with O-linked N-acetylglucosamine (O-GlcNAc) catalysed by O-GlcNAc transferase (OGT) has been linked to regulation of diverse cellular functions. OGT possesses a C-terminal glycosyltransferase
Externí odkaz:
https://doaj.org/article/b94e298faec4481fb80bf832bb42dfae
Publikováno v:
Open Biology, Vol 3, Iss 9 (2013)
The fungal cell possesses an essential carbohydrate cell wall. The outer layer, mannan, is formed by mannoproteins carrying highly mannosylated O- and N-linked glycans. Yeast mannan biosynthesis is initiated by a Golgi-located complex (M-Pol I) of tw
Externí odkaz:
https://doaj.org/article/083fa06e0fc140ef9d5ea603c9513d0a