Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Daan M F, van Aalten"'
Autor:
Florence Authier, Nina Ondruskova, Andrew T. Ferenbach, Alison D. McNeilly, Daan M. F. van Aalten
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/efc22cabbb364e4299dad3bb5b55dac5
Autor:
Leandro R. Soria, Georgios Makris, Alfonso M. D’Alessio, Angela De Angelis, Iolanda Boffa, Veronica M. Pravata, Véronique Rüfenacht, Sergio Attanasio, Edoardo Nusco, Paola Arena, Andrew T. Ferenbach, Debora Paris, Paola Cuomo, Andrea Motta, Matthew Nitzahn, Gerald S. Lipshutz, Ainhoa Martínez-Pizarro, Eva Richard, Lourdes R. Desviat, Johannes Häberle, Daan M. F. van Aalten, Nicola Brunetti-Pierri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Hyperammonemia occurs in liver diseases affecting ureagenesis, and is life-threatening. Here, the authors show that liver UDP-GlcNAc is increased during hyperammonemia, leading to O-GlcNAcylation of the rate-limiting ureagenesis enzyme CPS1, that enh
Externí odkaz:
https://doaj.org/article/f7dd4ac66ee843bca09996d7cef4b0de
Autor:
Michaela Omelková, Christina Dühring Fenger, Marta Murray, Trine Bjørg Hammer, Veronica M. Pravata, Sergio Galan Bartual, Ignacy Czajewski, Allan Bayat, Andrew T. Ferenbach, Marios P. Stavridis, Daan M. F. van Aalten
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/6c57373f8d2a40f7b2a046c323d0064e
Autor:
Yao Zhou, Kaizhou Yan, Qijian Qin, Olawale G. Raimi, Chao Du, Bin Wang, Chukwuemeka Samson Ahamefule, Bartosz Kowalski, Cheng Jin, Daan M. F. van Aalten, Wenxia Fang
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Aspergillus fumigatus is a devastating opportunistic fungal pathogen causing hundreds of thousands of deaths every year. Phosphoglucose isomerase (PGI) is a glycolytic enzyme that converts glucose-6-phosphate to fructose-6-phosphate, a key p
Externí odkaz:
https://doaj.org/article/35b7683a45a5434ca20a82b41dcf8cdb
Autor:
Michaela Fenckova, Villo Muha, Daniel Mariappa, Marica Catinozzi, Ignacy Czajewski, Laura E R Blok, Andrew T Ferenbach, Erik Storkebaum, Annette Schenck, Daan M F van Aalten
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010159 (2022)
O-GlcNAcylation is a reversible co-/post-translational modification involved in a multitude of cellular processes. The addition and removal of the O-GlcNAc modification is controlled by two conserved enzymes, O-GlcNAc transferase (OGT) and O-GlcNAc h
Externí odkaz:
https://doaj.org/article/267272faa05a4b8e9499b0a7286ccd9b
Autor:
Wenxia Fang, Ana Belén Sanz, Sergio Galan Bartual, Bin Wang, Andrew T. Ferenbach, Vladimír Farkaš, Ramon Hurtado-Guerrero, Javier Arroyo, Daan M. F. van Aalten
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Transglycosylases strengthen the fungal cell wall by forming a rigid network of crosslinks. Here, Fang et al. show that the five Crh transglycosylases of Aspergillus fumigatus are dispensable for cell wall integrity in vitro, and solve the crystal st
Externí odkaz:
https://doaj.org/article/4d8d21ce0ca04436bd06a9ebe173e048
Autor:
Zhanliang Liu, Laurie M. Gay, Tina R. Tuveng, Jane W. Agger, Bjørge Westereng, Geir Mathiesen, Svein J. Horn, Gustav Vaaje-Kolstad, Daan M. F. van Aalten, Vincent G. H. Eijsink
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Enzymatic conversion of chitin, a β-1,4 linked polymer of N-acetylglucosamine, is of major interest in areas varying from the biorefining of chitin-rich waste streams to understanding how medically relevant fungi remodel their chitin-contai
Externí odkaz:
https://doaj.org/article/f472978cdfdc47b99927ec6827d307b8
Autor:
Villo Muha, Ritchie Williamson, Rachel Hills, Alison D. McNeilly, Thomas G. McWilliams, Jana Alonso, Marianne Schimpl, Aneika C. Leney, Albert J. R. Heck, Calum Sutherland, Kevin D. Read, Rory J. McCrimmon, Simon P. Brooks, Daan M. F. van Aalten
Publikováno v:
Open Biology, Vol 9, Iss 11 (2019)
O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain la
Externí odkaz:
https://doaj.org/article/9e64e5af2f29476f9e4eeb84d52a4cc3
Autor:
Michaela Omelková, Christina Dühring Fenger, Marta Murray, Trine Bjørg Hammer, Veronica M. Pravata, Sergio Galan Bartual, Ignacy Czajewski, Allan Bayat, Andrew T. Ferenbach, Marios P. Stavridis, Daan M. F. van Aalten
O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential enzyme that modifies proteins with O-GlcNAc. InbornOGTgenetic variants were recently shown to mediate a novel type of Congenital Disorder of Glycosylation (OGT-CDG) which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::082e817270bc041dff49a3eae394dc39
https://doi.org/10.1101/2023.03.13.531514
https://doi.org/10.1101/2023.03.13.531514
Publikováno v:
Czajewski, I & van Aalten, D M F 2023, ' The role of O-GlcNAcylation in development ', Development, vol. 150, no. 6, dev201370 . https://doi.org/10.1242/dev.201370
O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04a2e9e9a8f59143b1c7eeb5e97b85c
https://pure.au.dk/portal/da/publications/the-role-of-oglcnacylation-in-development(f5fd6f89-a092-4c91-8a91-1f39c4d125f7).html
https://pure.au.dk/portal/da/publications/the-role-of-oglcnacylation-in-development(f5fd6f89-a092-4c91-8a91-1f39c4d125f7).html