Zobrazeno 1 - 5
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pro vyhledávání: '"Daan F. Boreel"'
Autor:
Anne P. M. Beerkens, Daan F. Boreel, James A. Nathan, Jiri Neuzil, Gang Cheng, Balaraman Kalyanaraman, Micael Hardy, Gosse J. Adema, Sandra Heskamp, Paul N. Span, Johan Bussink
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background Hypoxia is a common feature of many solid tumors and causes radiotherapy and immunotherapy resistance. Pharmacological inhibition of oxidative phosphorylation (OXPHOS) has emerged as a therapeutic strategy to reduce hypoxia. Howev
Externí odkaz:
https://doaj.org/article/6158a99077a34dd2a03b9ab6923fa43f
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
In response to the recent paper by Chen et al investigating the triple combination of oxidative phosphorylation inhibition, immunotherapy and radiotherapy, we would like to stress that after irradiation, a strong reduction in hypoxia (within 24 hours
Externí odkaz:
https://doaj.org/article/03387f4b9c1c4cb296676e283d484c9e
Publikováno v:
Clinical Cancer Research, 27, 11, pp. 2970-2978
Clinical Cancer Research, 27, 2970-2978
Clinical Cancer Research, 27, 2970-2978
As tumors grow, they upregulate glycolytic and oxidative metabolism to support their increased and altered energetic demands. These metabolic changes have major effects on the tumor microenvironment. One of the properties leading to this aberrant met
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Journal for Immunotherapy of Cancer, 9
Journal for Immunotherapy of Cancer, 9, 3
Journal for Immunotherapy of Cancer, 9
Journal for Immunotherapy of Cancer, 9, 3
Contains fulltext : 232184.pdf (Publisher’s version ) (Open Access) In response to the recent paper by Chen et al investigating the triple combination of oxidative phosphorylation inhibition, immunotherapy and radiotherapy, we would like to stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfd09fcc7ff895be7130f5a3f9a223e
https://doi.org/10.1136/jitc-2020-001793
https://doi.org/10.1136/jitc-2020-001793
Autor:
Daan F. Boreel, Paul Span, Hans Peters, Renske J.E. van den Bijgaart, Sandra Heskamp, Gosse J. Adema, Johan Bussink
Publikováno v:
Molecular Cancer Therapeutics. 20:P264-P264
When tumors outgrow their chaotic vasculature, limited diffusion of oxygen into remote tumor areas combined with increased oxygen consumption leads to hypoxia in most solid tumors. This oxygen scarcity is known to induce radioresistance, but may also