Výsledky vyhledávání - "Daan F. Boreel"

Akademický článek

Inhibition of OXPHOS induces metabolic rewiring and reduces hypoxia in murine tumor models

Autor: Daan F. Boreel, Anne P.M. Beerkens, Sandra Heskamp, Milou Boswinkel, Johannes P.W. Peters, Gosse J. Adema, Paul N. Span, Johan Bussink

Publikováno v: Clinical and Translational Radiation Oncology, Vol 49, Iss , Pp 100875- (2024)

Introduction: Tumor hypoxia is a feature of many solid malignancies and is known to cause radio resistance. In recent years it has become clear that hypoxic tumor regions also foster an immunosuppressive phenotype and are involved in immunotherapy re

Externí odkaz: https://doaj.org/article/cae6230e8058466b98f4a09faac3e1ce

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Akademický článek

Characterizing OXPHOS inhibitor-mediated alleviation of hypoxia using high-throughput live cell-imaging

Autor: Anne P. M. Beerkens, Daan F. Boreel, James A. Nathan, Jiri Neuzil, Gang Cheng, Balaraman Kalyanaraman, Micael Hardy, Gosse J. Adema, Sandra Heskamp, Paul N. Span, Johan Bussink

Publikováno v: Cancer & Metabolism, Vol 12, Iss 1, Pp 1-10 (2024)

Abstract Background Hypoxia is a common feature of many solid tumors and causes radiotherapy and immunotherapy resistance. Pharmacological inhibition of oxidative phosphorylation (OXPHOS) has emerged as a therapeutic strategy to reduce hypoxia. Howev

Externí odkaz: https://doaj.org/article/6158a99077a34dd2a03b9ab6923fa43f

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Akademický článek

Letter to the editor: Hypoxia kinetics and histology in combined radiotherapy and oxidative phosphorylation inhibition effects on antitumor immunity

Autor: Daan F Boreel, Paul N Span, Johan Bussink

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)

In response to the recent paper by Chen et al investigating the triple combination of oxidative phosphorylation inhibition, immunotherapy and radiotherapy, we would like to stress that after irradiation, a strong reduction in hypoxia (within 24 hours

Externí odkaz: https://doaj.org/article/03387f4b9c1c4cb296676e283d484c9e

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Targeting Oxidative Phosphorylation to Increase the Efficacy of Radio- and Immune-Combination Therapy

Autor: Gosse J. Adema, Paul N. Span, Sandra Heskamp, Daan F. Boreel, Johan Bussink

Publikováno v: Clinical Cancer Research, 27, 11, pp. 2970-2978
Clinical Cancer Research, 27, 2970-2978

As tumors grow, they upregulate glycolytic and oxidative metabolism to support their increased and altered energetic demands. These metabolic changes have major effects on the tumor microenvironment. One of the properties leading to this aberrant met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdafbe88a31f032eae426580889f62a8
https://hdl.handle.net/2066/235344

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Abstract P264: Targeting oxygen metabolism reduces hypoxia in the tumor microenvironment of a syngeneic mouse model

Autor: Daan F. Boreel, Paul Span, Hans Peters, Renske J.E. van den Bijgaart, Sandra Heskamp, Gosse J. Adema, Johan Bussink

Publikováno v: Molecular Cancer Therapeutics. 20:P264-P264

When tumors outgrow their chaotic vasculature, limited diffusion of oxygen into remote tumor areas combined with increased oxygen consumption leads to hypoxia in most solid tumors. This oxygen scarcity is known to induce radioresistance, but may also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c25948727e8a67a456c5790e5dc5060e
https://doi.org/10.1158/1535-7163.targ-21-p264

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Letter to the editor: Hypoxia kinetics and histology in combined radiotherapy and oxidative phosphorylation inhibition effects on antitumor immunity

Autor: Paul N. Span, Johan Bussink, Daan F. Boreel

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Journal for Immunotherapy of Cancer, 9
Journal for Immunotherapy of Cancer, 9, 3

Contains fulltext : 232184.pdf (Publisher’s version ) (Open Access) In response to the recent paper by Chen et al investigating the triple combination of oxidative phosphorylation inhibition, immunotherapy and radiotherapy, we would like to stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfd09fcc7ff895be7130f5a3f9a223e
https://doi.org/10.1136/jitc-2020-001793

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