Obesity-Associated Changes in Immune Cell Dynamics During Alphavirus Infection Revealed by Single Cell Transcriptomic Analysis.

Autor: Hameed M; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.; Center for Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.; Department of Pathology & Immunology, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Daamen AR; AMPEL BioSolutions LLC and the RILITE Research Institute, Charlottesville, VA, United States., Hossain MS; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.; Center for Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA., Coutermarsh-Ott S; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA., Lipsky PE; AMPEL BioSolutions LLC and the RILITE Research Institute, Charlottesville, VA, United States., Weger-Lucarelli J; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.; Center for Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 13. Date of Electronic Publication: 2024 Oct 13.

The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus.

Autor: Li TM; Autoimmunity and Inflammation Program, Hospital for Special Surgery Research Institute, New York, United States., Zyulina V; Autoimmunity and Inflammation Program, Hospital for Special Surgery Research Institute, New York, United States.; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States., Seltzer ES; Autoimmunity and Inflammation Program, Hospital for Special Surgery Research Institute, New York, United States., Dacic M; David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery Research Institute, New York, United States.; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery Research Institute, New York, United States.; Physiology, Biophysics, and Systems Biology Program, Weill Cornell Graduate School of Medical Sciences, New York, United States., Chinenov Y; David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery Research Institute, New York, United States., Daamen AR; Department of Medicine, AMPEL BioSolutions, Charlottesville, United States., Veiga KR; Autoimmunity and Inflammation Program, Hospital for Special Surgery Research Institute, New York, United States.; Pediatric Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, United States.; Department of Pediatrics, Weill Cornell Medical College, New York, United States., Schwartz N; Autoimmunity and Inflammation Program, Hospital for Special Surgery Research Institute, New York, United States.; Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, United States., Oliver DJ; David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery Research Institute, New York, United States., Cabahug-Zuckerman P; Autoimmunity and Inflammation Program, Hospital for Special Surgery Research Institute, New York, United States., Lora J; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery Research Institute, New York, United States.; Physiology, Biophysics, and Systems Biology Program, Weill Cornell Graduate School of Medical Sciences, New York, United States., Liu Y; Department of Dermatology, Weill Cornell Medical College, New York, United States., Shipman WD; Autoimmunity and Inflammation Program, Hospital for Special Surgery Research Institute, New York, United States.; Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, Weill Cornell Medical College, New York, United States.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, United States., Ambler WG; Autoimmunity and Inflammation Program, Hospital for Special Surgery Research Institute, New York, United States.; Pediatric Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, United States.; Department of Pediatrics, Weill Cornell Medical College, New York, United States., Taber SF; Pediatric Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, United States.; Department of Pediatrics, Weill Cornell Medical College, New York, United States., Onel KB; Pediatric Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, United States.; Department of Pediatrics, Weill Cornell Medical College, New York, United States., Zippin JH; Department of Dermatology, Weill Cornell Medical College, New York, United States., Rashighi M; Department of Dermatology, University of Massachusetts Medical School, Worcester, United States., Krueger JG; Laboratory of Investigative Dermatology, Rockefeller University, New York, United States., Anandasabapathy N; Department of Dermatology, Weill Cornell Medical College, New York, United States.; Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, Weill Cornell Medical College, New York, United States.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, United States., Rogatsky I; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States.; David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery Research Institute, New York, United States.; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery Research Institute, New York, United States.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, United States., Jabbari A; Laboratory of Investigative Dermatology, Rockefeller University, New York, United States., Blobel CP; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery Research Institute, New York, United States.; Physiology, Biophysics, and Systems Biology Program, Weill Cornell Graduate School of Medical Sciences, New York, United States.; Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medical College, New York, United States., Lipsky PE; Department of Medicine, AMPEL BioSolutions, Charlottesville, United States., Lu TT; Autoimmunity and Inflammation Program, Hospital for Special Surgery Research Institute, New York, United States.; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, United States.; Pediatric Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, United States.; Department of Pediatrics, Weill Cornell Medical College, New York, United States.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, United States.

Publikováno v: ELife [Elife] 2024 Jun 11; Vol. 13. Date of Electronic Publication: 2024 Jun 11.

Obesity fosters severe disease outcomes in a mouse model of coronavirus infection associated with transcriptomic abnormalities.

Autor: Rai P; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD College of Veterinary Medicine, Blacksburg, Virginia, USA.; Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Tech, Blacksburg, Virginia, USA., Marano JM; Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Tech, Blacksburg, Virginia, USA.; Translational Biology, Medicine, and Health Graduate Program, Virginia Tech, Blacksburg, Virginia, USA., Kang L; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD College of Veterinary Medicine, Blacksburg, Virginia, USA.; Biomedical Affairs and Research, Edward Via College of Osteopathic Medicine, Monroe, Louisiana, USA.; College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana, USA., Coutermarsh-Ott S; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD College of Veterinary Medicine, Blacksburg, Virginia, USA., Daamen AR; AMPEL BioSolutions LLC, Charlottesville, Virginia, USA., Lipsky PE; AMPEL BioSolutions LLC, Charlottesville, Virginia, USA., Weger-Lucarelli J; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD College of Veterinary Medicine, Blacksburg, Virginia, USA.; Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Tech, Blacksburg, Virginia, USA.

Publikováno v: Journal of medical virology [J Med Virol] 2024 Apr; Vol. 96 (4), pp. e29587.

An interpretable machine learning pipeline based on transcriptomics predicts phenotypes of lupus patients.

Autor: Leventhal EL; AMPEL BioSolutions LLC, and the RILITE Research Institute, Charlottesville, VA 22902, USA., Daamen AR; AMPEL BioSolutions LLC, and the RILITE Research Institute, Charlottesville, VA 22902, USA., Grammer AC; AMPEL BioSolutions LLC, and the RILITE Research Institute, Charlottesville, VA 22902, USA., Lipsky PE; AMPEL BioSolutions LLC, and the RILITE Research Institute, Charlottesville, VA 22902, USA.

Publikováno v: IScience [iScience] 2023 Sep 25; Vol. 26 (10), pp. 108042. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).

Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment.

Autor: Wilson JJ; The Jackson Laboratory, Bar Harbor, Maine, ME 04609, USA., Wei J; The Jackson Laboratory, Bar Harbor, Maine, ME 04609, USA.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, China., Daamen AR; AMPEL BioSolutions and the RILITE Research Institute, Charlottesville, VA 22902, USA., Sears JD; The Jackson Laboratory, Bar Harbor, Maine, ME 04609, USA.; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA., Bechtel E; The Jackson Laboratory, Bar Harbor, Maine, ME 04609, USA., Mayberry CL; The Jackson Laboratory, Bar Harbor, Maine, ME 04609, USA., Stafford GA; The Jackson Laboratory, Bar Harbor, Maine, ME 04609, USA., Bechtold L; The Jackson Laboratory, Bar Harbor, Maine, ME 04609, USA., Grammer AC; AMPEL BioSolutions and the RILITE Research Institute, Charlottesville, VA 22902, USA., Lipsky PE; AMPEL BioSolutions and the RILITE Research Institute, Charlottesville, VA 22902, USA., Roopenian DC; The Jackson Laboratory, Bar Harbor, Maine, ME 04609, USA., Chang CH; The Jackson Laboratory, Bar Harbor, Maine, ME 04609, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, USA.; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.

Publikováno v: IScience [iScience] 2023 Jul 27; Vol. 26 (9), pp. 107487. Date of Electronic Publication: 2023 Jul 27 (Print Publication: 2023).