Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity.

Autor: Rutten L; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Swart M; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Koornneef A; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Bouchier P; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Blokland S; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Sadi A; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Juraszek J; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Vijayan A; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Schmit-Tillemans S; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Verspuij J; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Choi Y; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Daal CE; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Perkasa A; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Torres Morales S; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Myeni SK; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Kikkert M; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Tolboom J; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., van Manen D; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Kuipers H; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Schuitemaker H; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Zahn R; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Langedijk JPM; Janssen Vaccines and Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands. hlangedijk@forge-bio.com.; ForgeBio, Amsterdam, The Netherlands. hlangedijk@forge-bio.com.

Publikováno v: Scientific reports [Sci Rep] 2024 Mar 08; Vol. 14 (1), pp. 5735. Date of Electronic Publication: 2024 Mar 08.