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Akademický článek

An improved method for diagnosis of Parkinson’s disease using deep learning models enhanced with metaheuristic algorithm

Autor: Babita Majhi, Aarti Kashyap, Siddhartha Suprasad Mohanty, Sujata Dash, Saurav Mallik, Aimin Li, Zhongming Zhao

Publikováno v: BMC Medical Imaging, Vol 24, Iss 1, Pp 1-20 (2024)

Abstract Parkinson's disease (PD) is challenging for clinicians to accurately diagnose in the early stages. Quantitative measures of brain health can be obtained safely and non-invasively using medical imaging techniques like magnetic resonance imagi

Externí odkaz: https://doaj.org/article/88320d200a9e4129964518ddf2788c3e

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Akademický článek

Practical use of DAT SPECT imaging in diagnosing dementia with Lewy bodies: a US perspective of current guidelines and future directions

Autor: Deirdre M. O’Shea, Alexander Arkhipenko, Douglas Galasko, Jennifer G. Goldman, Zulfiqar Haider Sheikh, George Petrides, Jon B. Toledo, James E. Galvin

Publikováno v: Frontiers in Neurology, Vol 15 (2024)

BackgroundDiagnosing Dementia with Lewy Bodies (DLB) remains a challenge in clinical practice. The use of 123I-ioflupane (DaTscan™) SPECT imaging, which detects reduced dopamine transporter (DAT) uptake—a key biomarker in DLB diagnosis—could im

Externí odkaz: https://doaj.org/article/390aa9c12abd4dd6813fc1e1923d4d62

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Akademický článek

Association between body mass index (BMI) and [123I]Ioflupane (DaTSCAN) availabilities in patients with parkinsonism using single-photon emission computed tomography–computed tomography (SPECT-CT)

Autor: Puja Parekh, Patrick Begley, Maryam Jessop, Mark Aplin, Elena Missir, Helena McMeekin, Gosia Raczek, Nitasha Singh, Sabina Dizdarevic

Publikováno v: European Journal of Hybrid Imaging, Vol 7, Iss 1, Pp 1-19 (2023)

Abstract Aim [123I]Ioflupane (DaTSCAN) has a high binding affinity to the dopamine (DA) transporter (DaT) and tenfold less affinity to serotonin (5-HT) transporter (SERT). Both neurotransmitters are considered to contribute to body weight regulation.

Externí odkaz: https://doaj.org/article/5ed6906cb95d42359aa76521dce8e924

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Akademický článek

Study in Parkinson’s disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-26 (2022)

Abstract Background To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with PD. The key question

Externí odkaz: https://doaj.org/article/76455c85f6a1412282dc3e5f90536c78

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Akademický článek

Quantitative dopamine transporter imaging assessment in Parkinson's disease patients carrying GBA gene mutations compared with idiopathic PD patients: A case‐control study

Autor: Sara Grisanti, Alessandro Fraternali, Francesco Cavallieri, Valentina Fioravanti, Massimiliano Casali, Giulia Toschi, Laura Ferri, Rossella Sabadini, Marialuisa Zedde, Gaetano Salomone, Manuela Napoli, Rosario Pascarella, Valeria Ferrari, Maria Scarano, Giuseppe Biagini, Augusto Scaglioni, Elena Moro, Annibale Versari, Franco Valzania

Publikováno v: Brain and Behavior, Vol 13, Iss 7, Pp n/a-n/a (2023)

Abstract Background Genetic risk factors impact around 15% of Parkinson's disease (PD) patients and at least 23 variants have been identified including Glucocerebrosidase (GBA) gene variants. Using different clinical and instrumental qualitative‐ba

Externí odkaz: https://doaj.org/article/f544533d88414a4ebded8e26733453d3

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Akademický článek

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Akademický článek

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Akademický článek

[18F]FE-PE2I PET is a feasible alternative to [123I]FP-CIT SPECT for dopamine transporter imaging in clinically uncertain parkinsonism

Autor: Lisbeth Marner, Kirsten Korsholm, Lasse Anderberg, Markus N. Lonsdale, Mads Radmer Jensen, Eva Brødsgaard, Charlotte L. Denholt, Nic Gillings, Ian Law, Lars Friberg

Publikováno v: EJNMMI Research, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Background Dopamine transporter (DAT) imaging of striatum is clinically used in Parkinson’s disease (PD) and neurodegenerative parkinsonian syndromes (PS) especially in the early disease stages. The aim of the present study was to evaluate

Externí odkaz: https://doaj.org/article/af8d48df9f1048ad9e47a71355912673

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Akademický článek

Accelerated high frequency rTMS induces time-dependent dopaminergic alterations: a DaTSCAN brain imaging study in healthy beagle dogs

Autor: Yangfeng Xu, Kathelijne Peremans, Sofie Salden, Kurt Audenaert, Andre Dobbeleir, Ann Van Eeckhaut, Dimitri De Bundel, Jimmy H. Saunders, Chris Baeken

Publikováno v: Frontiers in Veterinary Science, Vol 10 (2023)

AimThe neurobiological effects of repetitive transcranial magnetic stimulation are believed to run in part through the dopaminergic system. Accelerated high frequency rTMS (aHF-rTMS), a new form of stimuli delivery, is currently being tested for its

Externí odkaz: https://doaj.org/article/e034e39574cb40079b782952c7821444

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